The rate at which serum total β-subunit human chorionic gonadotropin increases after embryo transfer is a predictor of the viability of pregnancy and an identifier of determinants of pregnancy

References 

1. Stone BA, Quinn P, Vargyas JM, Marrs RP. Responses of patients to different lots of human menopausal gonadotropins during ovarian hyperstimulation. Fertil Steril. 1989;52:745–752
   • MEDLINE
2. Stone BA, Quinn P, Marrs RP. Between-lot variability in chromatographic and biochemical prop-erties of human menopausal gonadotropins. Acta Endocrinologica (Copenhagen). 1990;123:161–168
3. Rector NA, Markusen TE, Stone BA, Marrs RP. Numbers and quality of oocytes following induction of multiple folliculogenesis in women and in mice with different lots of human menopausal gonadotropins (hMG). Fertil Steril. 1993;60:1082–1087
   • MEDLINE
4. Devroey P, Bourgain C, Macklon NS, Fauser BC. Reproductive biology and IVF:ovarian stimulation and endometrial receptivity. Trends Endocrinol Metab (United States). 2004;15:84–90
5. Pittaway DE, Wentz AC, Maxson WS, Herbert C, Danilee J, Fleischer AC. The efficacy of early pregnancy monitoring with serial chorionic gonadotropin determinations and real-time sonography in an infertility population. Fertil Steril. 1985;44:190–194
   • MEDLINE
6. ACOG Committee on Gynecologic Practice. Avoiding inappropriate clinical decisions based on false-positive human chorionic gonadotropin test results. Int J Gynaecol Obstet (Ireland). 2003;80:231–233
7. Check JH, Weiss RM, Lurie D. Analysis of serum human chorionic gonadotropin levels in normal singleton, multiple and abnormal pregnancies. Hum Reprod (England). 1992;7:1176–1180
8. Tinga DJ, Van Lier JJ, De Bruijn HW. Doubling time and hCG score for the early diagnosis of ectopic pregnancy in asymptomatic women. Acta Obstet Gynecol Scand (Sweden). 1990;69:505–509
9. Kadar N, Freedman M, Zacher M. Further observation on the doubling time of human chorionic gonadotropin in early asymptomatic pregnancies. Fertil Steril. 1990;56:1204–1206
   • MEDLINE
10. Shepherd RW, Patton PE, Novy MJ, Burry KA. Serial beta-hCG measurements in early detection of ectopic pregnancy. Obstet Gynecol (United States). 1990;75:417–420
11. Davies S, Byrn F, Cole LA. Human chorionic gonadotropin testing for early pregnancy viability and complications. Clin Lab Med (United States). 2003;23:257–264
12. Letterie GS, Hay DL. Human chorionic gonadotropin and free beta subunit secretion in three events of pregnancy. Clin Exp Obstet Gynecol. 1991;18:215–219
    • MEDLINE
13. Tyrey L. Human chorionic gonadotropin: properties and assay methods. Semin Oncol. 1995;22:121–129
    • MEDLINE
14. Clark GM. Statistics and experimental design (Chapters 8, 12). London: Edward Arnold (Publishers) Ltd; 1969;
15. de la Rochebrochard E, Thonneau P. Paternal age maternal age and maternal age are risk factors for miscarriages; results of a multicentre study. Hum Reprod. 2002;17:1649–1656
    • MEDLINE
    • CrossRef
16. Abdalla HI, Burton G, Kirkland A, Johnson MR, Leonard T, Brooks AA, et al. Age, pregnancy and miscarriage: uterine versus ovarian factors. Hum Reprod. 1993;8:1512–1517
    • MEDLINE
17. Ruman J, Klein J, Sauer MV. Understanding the effects of age on female fertility. Minerva Ginecol (Italy). 2003;55:117–127
18. Levene H. Robust tests for the equality of variances. In:  Olkin I editors. Contributions to probability and statistics. Palo Alto, California: Stanford University Press; 1960;p. 278–292
19. SAS Institute, Inc. SAS user’s guide: statistics. Cary, NC: SAS Institute; 1985;Version 5 ed.
20. Welch RE. Stepwise multiple comparison procedures. J Am Stat Assoc. 1977;72:566–575
21. Elinot I, Gabriel KR. A study of the powers of several methods of multiple comparisons. J Am Stat Assoc. 1975;70:574–583
22. Dennis JE, Schnabel RB. Numerical methods for unconstrained optimization and non-linear equations. Englewood Cliffs, New Jersey: Prentice Hall; 1983;
23. Levenberg K. A method for the solution of certain problems in least squares. Quart Jrnl Appl Math. 1944;2:164–168
24. Marquardt D. An algorithm for least-squares estimation of non-linear parameters. Soc Ind Appl Math, Jrnl Appl Math. 1963;1:431–441
25. Nash JC. Nonlinear parameter estimation. New York: Marcel Decker; 1987;
26. Sawyer JW. First partial differentiation by computer with an application to categorical data analysis. Am Statistic. 1984;38:300–308
27. Wexler AS. An algorithm for exact evaluation of multivariate functions and their derivatives to any order. Comp Statistics Data Anal. 1988;6:1–6
28. Heiner JS, Kerin JF, Schmidt LL, Wu TC. Can a single, early quantitative human chorionic gonadotropin measurement in an in vitro fertilization–gamete intrafallopian transfer program predict pregnancy outcome?. Fertil Steril. 1992;58:373–377
    • MEDLINE
29. Ertzeid G, Tanbo T, Dale PO, Storeng R, Moorkrid L, Abyholm T. Human chorionic gonadotropin levels in successful implantations after assisted reproduction techniques. Gynecol Endocrinol (England). 2002;14:258–263
30. Glatstein IZ, Hornstein MD, Kahana MJ, Jackson KV, Friedman AJ. The predictive value of discriminatory human chorionic gonadotropin levels in the diagnosis of implantation outcome in in vitro fertilization cycles. Fertil Steril. 1995;63:350–356
    • MEDLINE
31. Matthews CP, Coulson PB, Wild RA. Serum progesterone levels as an aid in the diagnosis of ectopic pregnancy. Obstet Gynecol. 1997;50:145–148
    • MEDLINE
32. Stovall TG, Ling FW, Cope BJ, Buster JE. Preventing ruptured ectopic pregnancy with a single serum progesterone. Am J Obstet Gynecol. 1989;160:1425–1428
    • Abstract
    • Full-Text PDF (887 KB)
33. Isaacs JD, Whitworth NS, Cowan BD. Relative operating characteristic analysis in reproductive medicine: comparison of progesterone and human chorionic gonadotropin doubling time as predictors of early gestational normalcy. Fertil Steril. 1994;62:452–455
    • MEDLINE
34. Long CA, Lincoln SR, Whitworth NS, Cowan BD. Progesterone concentration as a predictor of pregnancy normalcy is the most useful when hCG levels are less than 2000 mIU/mL. J Assist Reprod Genet (United States). 1995;12:195–197
35. Long CA, Lincoln SR, Whitworth NS, Cowan BD. Serum progesterone predicts abnormal gestations in clomiphene citrate conception cycles as well as in spontaneous conception cycles. Fertil Steril. 1994;61:838–842
    • MEDLINE
36. Gelder MS, Boots LR, Younger JB. Use of a single random serum progesterone value as a diagnostic aid for ectopic pregnancy. Fertil Steril. 1991;55:497–500
    • MEDLINE
37. Check JH, Check ML. A case report demonstrating that follicle maturing drugs may create an adverse uterine environment even when not used for controlled ovarian hyperstimulation. Clin Expo Obstet Gynecol (Italy). 2001;28:217–218
38. Check JH, Summers-Chase D, Nazari A, Kiefer D, Swenson K. The importance of numbers of blastomeres when embryos are transferred in the absence of controlled ovarian hyperstimulation. Clin Exp Obstet Gynecol (Italy). 2002;29:257–258
39. Stadtmauer L, Ditkoff EC, Session D, Kelly A. High dosages of gonadotropins are associated with poor pregnancy outcomes after in vitro fertilization–embryo transfer. Fertil Steril. 1994;61:1058–1064
    • MEDLINE
40. Check ML, Check JH, Wilson C, Choe JK, Krotec J. Outcome of in vitro fertilization–embryo transfer according to age in poor responders with elevated baseline serum follicle stimulating hormone using minimal or no gonadotropin stimulation. Clin Exp Obstet. 2004;21:183–184
41. Shapiro BS, Harris DC, Richter KS. Predictive value of 72-hour blastomere cell number on blastocyst development and success of subsequent transfer based on degree of blastocyst development. Fertil Steril. 2000;73:582–586
    • Abstract
    • Full Text
    • Full-Text PDF (84 KB)
    • CrossRef
42. Wilcox AJ. Surveillance of pregnancy loss in human populations. Am J Indust Med. 1983;4:285–291
43. Wilcox AJ, Weinberg CR, Wehmann RE, Armstrong EG, Canfield RE, Nisula BC. Measuring early pregnancy loss: laboratory and field methods. Fertil Steril. 1985;44:366–374
    • MEDLINE