Fertility and Sterility
Volume 87, Issue 1 , Pages 53-59 , January 2007

Relationship between endometrial thickness and embryo implantation, based on 1,294 cycles of in vitro fertilization with transfer of two blastocyst-stage embryos

Presented at the 62nd Annual Meeting of the American Society for Reproductive Medicine, New Orleans, Louisiana, October 21–25, 2006.

  • Kevin S. Richter, Ph.D.

      Affiliations

    • Shady Grove Fertility Reproductive Science Center, Rockville, Maryland
    • Corresponding Author InformationReprint requests: Kevin S. Richter, Ph.D., Shady Grove Fertility Reproductive Science Center, 15001 Shady Grove Road, Suite 400, Rockville, Maryland 20850 (FAX: 301-340-0623).
    • ,
  • Kathleen R. Bugge, R.N.C.

      Affiliations

    • Shady Grove Fertility Reproductive Science Center, Rockville, Maryland
    • ,
  • Jason G. Bromer, M.D.

      Affiliations

    • Department of Obstetrics and Gynecology, Georgetown University, Washington, D.C.
    • ,
  • Michael J. Levy, M.D.

      Affiliations

    • Shady Grove Fertility Reproductive Science Center, Rockville, Maryland

Received 10 December 2005 ,Revised 25 May 2006 ,Accepted 25 May 2006.

References 

  1. Glissant A, de Mouzon J, Frydman R. Ultrasound study of the endometrium during in vitro fertilization cycles. Fertil Steril. 1985;44:786–790
  2. Gonen Y, Casper RF, Jacobson W, Blankier J. Endometrial thickness and growth during ovarian stimulation: a possible predictor of implantation in in vitro fertilization. Fertil Steril. 1989;52:446–450
  3. Kovacs P, Matyas S, Boda K, Kaali SG. The effect of endometrial thickness on IVF/ICSI outcome. Hum Reprod. 2003;18:2337–2341
  4. Abdalla HI, Brooks AA, Johnson MR, Kirkland A, Thomas A, Studd JW. Endometrial thickness: a predictor of implantation in ovum recipients?. Hum Reprod. 1994;9:363–365
  5. Check JH, Nowroozi K, Choe J, Dietterich C. Influence of endometrial thickness and echo patterns on pregnancy rates during in vitro fertilization. Fertil Steril. 1991;56:1173–1175
  6. Dickey RP, Olar TT, Curole DN, Taylor SN, Rye PH. Endometrial pattern and thickness associated with pregnancy outcome after assisted reproduction technologies. Hum Reprod. 1992;7:418–421
  7. Noyes N, Liu HC, Sultan K, Schattman G, Rosenwaks Z. Endometrial thickness appears to be a significant factor in embryo implantation in in-vitro fertilization. Hum Reprod. 1995;10:919–922
  8. Rinaldi L, Lisi F, Floccari A, Lisi R, Pepe G, Fishel S. Endometrial thickness as a predictor of pregnancy after in-vitro fertilization but not after intracytoplasmic sperm injection. Hum Reprod. 1996;11:1538–1541
  9. Zhang X, Chen CH, Confino E, Barnes R, Milad M, Kazer RR. Increased endometrial thickness is associated with improved treatment outcome for selected patients undergoing in vitro fertilization-embryo transfer. Fertil Steril. 2005;83:336–340
  10. Check JH, Nowroozi K, Choe J, Lurie D, Dietterich C. The effect of endometrial thickness and echo pattern on in vitro fertilization outcome in donor oocyte-embryo transfer cycle. Fertil Steril. 1993;59:72–75
  11. Noyes N, Hampton BS, Berkeley A, Licciardi F, Grifo J, Krey L. Factors useful in predicting the success of oocyte donation: a 3-year retrospective analysis. Fertil Steril. 2001;76:92–97
  12. Zenke U, Chetkowski RJ. Transfer and uterine factors are the major recipient-related determinants of success with donor eggs. Fertil Steril. 2004;82:850–856
  13. Gonen Y, Casper RF. Prediction of implantation by the sonographic appearance of the endometrium during controlled ovarian stimulation for in vitro fertilization (IVF). J In Vitro Fert Embryo Transfer. 1990;7:146–152
  14. Coulam CB, Bustillo M, Soenksen DM, Britten S. Ultrasonographic predictors of implantation after assisted reproduction. Fertil Steril. 1994;62:1004–1010
  15. Oliveira JB, Baruffi RL, Mauri AL, Petersen CG, Borges MC, Franco JG. Endometrial ultrasonography as a predictor of pregnancy in an in-vitro fertilization programme after ovarian stimulation and gonadotrophin-releasing hormone and gonadotrophins. Hum Reprod. 1997;12:2515–2518
  16. Liu HM, Xing FQ, Chen SL, Li H. [Predictive value of endometrial ultrasonography and age for the outcome of in vitro fertilization-embryo transfer]. Di Yi Jun Yi Da Xue Xue Bao. 2005;25:570–572
  17. Rashidi BH, Sadeghi M, Jafarabadi M, Tehrani Nejad ES. Relationships between pregnancy rates following in vitro fertilization or intracytoplasmic sperm injection and endometrial thickness and pattern. Eur J Obstet Gynecol Reprod Biol. 2005;120:179–184
  18. Yuval Y, Lipitz S, Dor J, Achiron R. The relationships between endometrial thickness, and blood flow and pregnancy rates in in-vitro fertilization. Hum Reprod. 1999;14:1067–1071
  19. Bassil S. Changes in endometrial thickness, width, length and pattern in predicting pregnancy outcome during ovarian stimulation in in vitro fertilization. Ultrasound Obstet Gynecol. 2001;18:258–263
  20. Schild RL, Knobloch C, Dorn C, Fimmers R, van der Ven H, Hansmann M. Endometrial receptivity in an in vitro fertilization program as assessed by spiral artery blood flow, endometrial thickness, endometrial volume, and uterine artery blood flow. Fertil Steril. 2001;75:361–366
  21. Puerto B, Creus M, Carmona F, Civico S, Vanrell JA, Balasch J. Ultrasonography as a predictor of embryo implantation after in vitro fertilization: a controlled study. Fertil Steril. 2003;79:1015–1022
  22. Laasch C, Puscheck E. Cumulative embryo score, not endometrial thickness, is best for pregnancy prediction in IVF. J Assist Reprod Genet. 2004;21:47–50
  23. Remohi J, Ardiles G, Garcia-Velasco JA, Gaitan P, Simon C, Pellicer A. Endometrial thickness and serum oestradiol concentrations as predictors of outcome in oocyte donation. Hum Reprod. 1997;12:2271–2276
  24. Garcia-Velasco JA, Isaza V, Caligara C, Pellicer A, Remohi J, Simon C. Factors that determine discordant outcome from shared oocytes. Fertil Steril. 2003;80:54–60
  25. Weissman A, Gotlieb L, Casper RF. The detrimental effect of increased endometrial thickness on implantation and pregnancy rates and outcome in an in vitro fertilization program. Fertil Steril. 1999;71:147–149
  26. Yakin K, Akarsu C, Kahraman S. Cycle lumping or sampling—a witches’ brew?. Fertil Steril. 2000;73:175
  27. Dietterich C, Check JH, Choe JK, Nazari A, Lurie D. Increased endometrial thickness on the day of human chorionic gonadotropin injection does not adversely affect pregnancy or implantation rates following in vitro fertilization-embryo transfer. Fertil Steril. 2002;77:781–786
  28. Yoeli R, Ashkenazi J, Orvieto R, Shelef M, Kaplan B, Bar-Hava I. Significance of increased endometrial thickness in assisted reproduction technology treatments. J Assist Reprod Genet. 2004;21:285–289
  29. Tucker MJ, Liebermann J. Morphological scoring of human embryos and its relevance to blastocyst transfer. In:  Patrizio P,  Tucker MJ,  Guelman V editor. A color atlas for human assisted reproduction. Philadelphia: Lippincott Williams & Wilkins; 2003;p. 99–108
  30. Sundstrom P. Establishment of a successful pregnancy following in-vitro fertilization with an endometrial thickness of no more than 4 mm. Hum Reprod. 1998;13:1550–1552
  31. Check JH, Dietterich C, Check ML, Katz Y. Successful delivery despite conception with a maximal endometrial thickness of 4 mm. Clin Exp Obstet Gynecol. 2003;30:93–94
  32. Quintero RB, Sharara FI, Milki AA. Successful pregnancies in the setting of exaggerated endometrial thickness. Fertil Steril. 2004;82:215–217
  33. Sher G, Dodge S, Maassarani G, Knutzen V, Zouves C, Feinman M. Management of suboptimal sonographic endometrial patterns in patients undergoing in-vitro fertilization and embryo transfer. Hum Reprod. 1993;8:347–349
  34. Weckstein LN, Jacobson A, Galen D, Hampton K, Hammel J. Low-dose aspirin for oocyte donation recipients with a thin endometrium: prospective, randomized study. Fertil Steril. 1997;68:927–930
  35. Urman B, Mercan R, Alatas C, Balaban B, Isiklar A, Nuhoglu A. Low-dose aspirin does not increase implantation rates in patients undergoing intracytoplasmic sperm injection: a prospective randomized study. J Assist Reprod Genet. 2000;17:586–590
  36. Hurst BS, Bhojwani JT, Marshburn PB, Papadakis MA, Loeb TA, Matthews ML. Low-dose aspirin does not improve ovarian stimulation, endometrial response, or pregnancy rates for in vitro fertilization. J Exp Clin Assist Reprod. 2005;2:8
  37. Sher G, Fisch JD. Effect of vaginal sildenafil on the outcome of in vitro fertilization (IVF) after multiple IVF failures attributed to poor endometrial development. Fertil Steril. 2002;78:1073–1076

PII: S0015-0282(06)03158-X

doi: 10.1016/j.fertnstert.2006.05.064

Fertility and Sterility
Volume 87, Issue 1 , Pages 53-59 , January 2007

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