Fertility and Sterility
Volume 87, Issue 3 , Pages 591-596 , March 2007

Impact of infertility drugs after treatment of borderline ovarian tumors: results of a retrospective multicenter study

  • Anne Fortin, M.D.

      Affiliations

    • Department of Obstetrics and Gynecology, Centre Hospitalier Universitaire Bichat, Paris, France
    • ,
  • Philippe Morice, M.D.

      Affiliations

    • Gynecologic Surgery, Institut Gustave Roussy, Villejuif, France
    • Corresponding Author InformationReprint requests: Philippe Morice, M.D., Institut Gustave Roussy, 39 rue Camille Desmoulins, 94805 Villejuif, France (FAX: 33.1.42.11.52.13).
    • ,
  • Anne Thoury, M.D.

      Affiliations

    • Department of Obstetrics and Gynecology, Centre Hospitalier Universitaire Bichat, Paris, France
    • ,
  • Sophie Camatte, M.D.

      Affiliations

    • Gynecologic Surgery, Institut Gustave Roussy, Villejuif, France
    • ,
  • Caroline Dhainaut, M.D.

      Affiliations

    • Department of Obstetrics and Gynecology, Centre Hospitalier Universitaire Bichat, Paris, France
    • ,
  • Patrick Madelenat, M.D.

      Affiliations

    • Department of Obstetrics and Gynecology, Centre Hospitalier Universitaire Bichat, Paris, France

Received 27 February 2006 ,Revised 20 July 2006 ,Accepted 20 July 2006.

References 

  1. Taylor HC. Malignant and semi-malignant tumors of the ovary. Surg Gynecol Obstet. 1929;48:204–230
  2. Morice P. Borderline tumor of the ovary and infertility. Eur J Cancer. 2006;42:149–158
  3. Atlas M, Menczer J. Massive hyperstimulation and borderline malignancy carcinoma of the ovary: a possible association. Acta Obstet Gynecol Scand. 1982;61:261–263
  4. Whittemore AS, Harris R, Itnyre J Collaborative Ovarian Cancer Group. Characteristics relating to ovarian cancer risk: collaborative analysis of 12 US case-control studies; II, invasive epithelial ovarian cancer in white women. Am J Epidemiol. 1992;136:1184–1203
  5. Rossing MA, Daling JR, Weiss NS, Moore DE, Self SG. Ovarian tumors in a cohort of infertile women. N Engl J Med. 1994;331:771–776
  6. Nijman HW, Burger CW, Baak JP, Schats R, Vermorken JB, Kenemans P. Borderline malignancy of the ovary and controlled hyperstimulation, a report of 2 cases. Eur J Cancer. 1992;12:1971–1973
  7. Mantzavinos T, Kanakas N, Genatas C, Papadias K, Zourlas PA. Five years’ follow-up in two patients with borderline tumours of the ovary hyperstimulated by gonadotrophin therapy for in-vitro fertilization. Hum Reprod. 1994;9:2032–2033
  8. Hershkovitz R, Lunenfeld E, Piura B, Pak I, Leiberman JR, Yanai-Inbar I, et al. Ovulation induction in three infertile patients with ovarian tumor. Israel J Obstet Gynecol. 1998;9:271–275
  9. Hoffman JS, Laird L, Benadiva C, Dreiss R. In vitro fertilization following conservative management of stage 3 serous borderline tumor of the ovary. Gynecol Oncol. 1999;74:515–518
  10. Morris RT, Gershenson DM, Silva EG, Follen M, Morris M, Wharton JT. Outcome and reproductive function after conservative surgery for borderline ovarian tumors. Obstet Gynecol. 2000;95:541–547
  11. Beiner ME, Gotlieb WH, Davidson B, Kopolovic J, Ben-Baruch G. Infertility treatment after conservative management of borderline ovarian tumors. Cancer. 2001;92:320–325
  12. Attar E, Berckman S, Topuz S, Baysal B, Akhan S, Chambers JT. Evolutive peritoneal disease after conservative management and the infertility drugs in a patient with stage IIIC borderline micropapillary serous carcinoma (MPSC) of the ovary: case report. Hum Reprod. 2004;19:1472–1475
  13. Fasouliotis S, Davis O, Schattman G, Spandorfer SD, Kigman I, Rosenwaks Z. Safety and efficacy of infertility treatment after conservative management of borderline ovarian tumors: a preliminary report. Fertil Steril. 2004;82:568–572
  14. Fauvet R, Poncelet C, Boccara J, Descamps P, Fondrinier E, Darai E. Fertility after conservative treatment for borderline ovarian tumors: a French multicenter study. Fertil Steril. 2005;83:284–290
  15. International Federation of Gynecology and Obstetrics. Changes in definitions of clinical staging for carcinoma of the cervix and ovary. Am J Obstet Gynecol. 1987;156:263–264
  16. Bell DA, Scully RE. Serous borderline tumors of the peritoneum. Am J Surg Pathol. 1990;14:230–239
  17. Gotlieb W, Flikker S, Davidson B, Korach Y, Kopolovic J, Ben-Baruch G. Borderline tumors of the ovary: fertility treatment, conservative management, and pregnancy outcome. Cancer. 1998;82:141–146
  18. Mosgaard BJ, Lidegaard O, Kjaer SK, Schou G, Andersen AN. Ovarian stimulation and borderline ovarian tumors: a case-control study. Fertil Steril. 1998;70:1049–1055
  19. Ness RB, Cramer DW, Goodman MT, Kjaer SK, Mallin K, Mosgaard BJ, et al. Infertility, fertility drugs and ovarian cancer: a pooled analysis of case-control studies. Am J Epidemiol. 2002;155:217–224
  20. Rossing MA, Tang MT, Flagg EW, Weiss LK, Wicklund KG. A case-control study of ovarian cancer in relation to infertility and the use of ovulation-inducing drugs. Am J Epidemiol. 2004;160:1070–1078
  21. Tourgeman D, Lu JJ, Boostanfar R, Amezcua C, Felix JC, Paulson RJ, et al. Human chorionic gonadotropin suppresses ovarian epithelial neoplastic cell proliferation in vitro. Fertil Steril. 2002;78:1096–1099
  22. Morice P, Camatte S, El Hassan J, Pautier P, Duvillard P, Castaigne D. Clinical outcomes and fertility results after conservative treatment for ovarian borderline tumor. Fertil Steril. 2001;75:92–96
  23. Zanetta G, Rota S, Chiari S, Bonazzi C, Bratina G, Mangioni C, et al. Behavior of borderline tumors with particular interest to persistence, recurrence, and progression to invasive carcinoma: a prospective study. J Clin Oncol. 2001;19:2658–2664
  24. Camatte S, Morice P, Pautier P, Atallah D, Duvillard P, Castaigne D. Fertility results after conservative treatment of advanced stage serous borderline tumors of the ovary. Br J Obstet Gynecol. 2002;109:376–380
  25. Gershenson DM, Silva EG, Tortorelo-Luna G, Levenback C, Morris M, Tornos C. Serous borderline tumors of the ovary with noninvasive peritoneal implants. Cancer. 1998;83:2157–2163
  26. Gallot D, Pouly JL, Janny L, Mage G, Canis M, Wattiez A, et al. Successful transfer of frozen-thawed embryos obtained immediately before radical surgery for a stage IIIa serous borderline ovarian tumour: case report. Hum Reprod. 2000;15:2347–2350
  27. Donnez J, Dolmans MM, Demylle D, Jadoul P, Pirard C, Squifflet J, et al. Livebirth after orthotopic transplantation of cryopreserved ovarian tissue. Lancet. 2004;364:1405–1410

PII: S0015-0282(06)04009-X

doi: 10.1016/j.fertnstert.2006.07.1503

Fertility and Sterility
Volume 87, Issue 3 , Pages 591-596 , March 2007

Article Tools