Fertility and Sterility
Volume 87, Issue 3 , Pages 603-606, March 2007

Exclusion of coding-region mutations in luteinizing hormone and follicle-stimulating hormone receptor genes as the cause of ovarian hyperstimulation syndrome

  • Erja Kerkelä, Ph.D.

      Affiliations

    • Department of Biosciences, Novum, Karolinska Institutet, Huddinge, Sweden
    • Institute for Regenerative Medicine (REGEA), University of Tampere, Tampere, Finland
    • ,
  • Heli Skottman, Ph.D.

      Affiliations

    • Institute for Regenerative Medicine (REGEA), University of Tampere, Tampere, Finland
    • ,
  • Barbro Friden, M.D.

      Affiliations

    • Fertility Center, Stockholm, Sweden
    • ,
  • Kerstin Bjuresten, Midwife

      Affiliations

    • Division of Obstetrics and Gynecology, Department of Clinical Innovation and Technology (CLINTEC), Karolinska University Hospital Huddinge, Karolinska Institutet, Stockholm, Sweden
    • ,
  • Juha Kere, M.D., Ph.D.

      Affiliations

    • Department of Biosciences, Novum, Karolinska Institutet, Huddinge, Sweden
    • ,
  • Outi Hovatta, M.D., Ph.D.

      Affiliations

    • Institute for Regenerative Medicine (REGEA), University of Tampere, Tampere, Finland
    • Division of Obstetrics and Gynecology, Department of Clinical Innovation and Technology (CLINTEC), Karolinska University Hospital Huddinge, Karolinska Institutet, Stockholm, Sweden
    • Corresponding Author InformationReprint requests: Outi Hovatta, M.D., Division of Obstetrics and Gynecology, Department of Clinical Innovation and Technology (CLINTEC), Karolinska University Hospital Huddinge, Karolinska Institutet, 14186 Stockholm, Sweden (FAX: 46-8-585-87575).

Received 6 March 2006; received in revised form 28 June 2006; accepted 28 June 2006. published online 30 October 2006.

Objective

To sequence the coding regions of the luteinizing hormone receptor (LHR) and follicle-stimulating hormone receptor (FSHR) genes to find out if polymorphisms in them are responsible for the severe form of ovarian hyperstimulation syndrome (OHSS) in Swedish patients.

Design

A mutation analysis of gonadotropin receptor genes from women undergoing gonadotropin treatment.

Setting

The Fertility Unit of Karolinska University Hospital Huddinge, Stockholm, Sweden.

Patient(s)

A set of 10 well-characterized patients with severe OHSS, and 10 control women who did not develop OHSS after FSH stimulation. An additional 11 patients and 41 control women were screened for a two-amino-acid insertion in the first exon of the LHR gene.

Intervention(s)

None.

Main Outcome Measure(s)

Changes in the sequence of the receptor genes between patients and controls.

Result(s)

No association was found between polymorphisms of the coding region of LHR or FSHR genes and the development of OHSS. Incidence of the two-amino-acid insertion in the first exon of the LHR gene was slightly higher in patients than in controls, but no statistically significant difference was seen.

Conclusion

LHR and FSHR coding polymorphisms are not a major cause of severe OHSS in Swedish patients.

Key Words: FSH receptor, LH receptor, mutation, ovarian hyperstimulation syndrome

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 This work was done at the Department of Biosciences, Novum, Karolinska Institutet, Huddinge, Sweden, and the Division of Obstetrics and Gynecology, Department of Clinical Innovation and Technology (CLINTEC), Karolinska University Hospital Huddinge, Karolinska Institutet, Stockholm, Sweden.Supported by the Academy of Finland, Helsinki, Finland, the Jalmari and Rauha Ahokas Foundation, Helsinki, Finland, and the Swedish Research Council, Stockholm, Sweden.

PII: S0015-0282(06)04022-2

doi:10.1016/j.fertnstert.2006.06.060

Fertility and Sterility
Volume 87, Issue 3 , Pages 603-606, March 2007

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