Fertility and Sterility
Volume 87, Issue 3 , Pages 554-564 , March 2007

The healthy men study: design and recruitment considerations for environmental epidemiologic studies in male reproductive health

  • Andrew F. Olshan, Ph.D.

      Affiliations

    • Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill
    • Corresponding Author InformationReprint requests: Andrew F. Olshan, Ph.D., CB#7435, 2101B McGavran-Greenberg Hall, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7435 (FAX: 919-966-2089)
    • ,
  • Sally D. Perreault, Ph.D.

      Affiliations

    • Reproductive Toxicology Division, US Environmental Protection Agency, Research Triangle Park, North Carolina
    • ,
  • Lorrie Bradley, B.A.

      Affiliations

    • Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill
    • ,
  • Rebecca M. Buus, Ph.D.

      Affiliations

    • Reproductive Toxicology Division, US Environmental Protection Agency, Research Triangle Park, North Carolina
    • ,
  • Lillian F. Strader, B.S.

      Affiliations

    • Reproductive Toxicology Division, US Environmental Protection Agency, Research Triangle Park, North Carolina
    • ,
  • Susan C. Jeffay, B.S.

      Affiliations

    • Reproductive Toxicology Division, US Environmental Protection Agency, Research Triangle Park, North Carolina
    • ,
  • Lyle Lansdell, M.S.

      Affiliations

    • Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill
    • ,
  • David A. Savitz, Ph.D.

      Affiliations

    • Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill
    • ,
  • Amy Herring, Ph.D.

      Affiliations

    • Department of Biostatistics, School of Public Health, University of North Carolina, Chapel Hill

Received 24 January 2006 ,Revised 17 July 2006 ,Accepted 17 July 2006.

References 

  1. Moline JM, Golden AL, Bar-Chama N, Smith E, Rauch ME, Chapin RE, et al. Exposure to hazardous substances and male reproductive health: a research framework. Environ Health Perspect. 2000;108:803–813
  2. Jorgensen N, Andersen AG, Eustache F, Irvine DS, Suominen J, Petersen JH, et al. Regional differences in semen quality in Europe. Hum Reprod. 2001;16:1012–1019
  3. Swan SH, Brazil C, Drobnis EZ, Liu F, Kruse RL, Hatch M, et al. Geographic differences in semen quality of fertile US males. Environ Health Perspect. 2003;111:414–420
  4. Swan SH, Kruse RL, Liu F, Barr DB, Drobnis EZ, Redmon JB, et al. Semen quality in relation to biomarkers of pesticide exposure. Environ Health Perspect. 2003;111:1478–1484
  5. Muller A, De La Rochebrochard E, Labbe-Decleves C, Jouannet P, Bujan L, Mieusset R, et al. Selection bias in semen studies due to self-selection of volunteers. Hum Reprod. 2004;19:2838–2844
  6. Fenster L, Waller K, Windham G, Henneman T, Anderson M, Mendola P, et al. Trihalomethane levels in home tap water and semen quality. Epidemiology. 2003;14:650–658
  7. Nieuwenhuijsen MJ, Toledano MB, Eaton NE, Fawell J, Elliott P. Chlorination disinfection byproducts in water and their association with adverse reproductive outcomes: a review. Occup Environ Med. 2000;57:73–85
  8. Bove F, Shim Y, Zeitz P. Drinking water contaminants and adverse pregnancy outcomes: a review. Environ Health Perspect. 2002;110:61–74
  9. Narotsky MG, Pegram RA, Kavlock RJ. Effect of dosing vehicle on the developmental toxicity of bromodichloromethane and carbon tetrachloride in rats. Fundam Appl Toxicol. 1997;40:30–36
  10. Toth GP, Kelty KC, George EL, Read EJ, Smith MK. Adverse male reproductive effects following subchronic exposure of rats to sodium dichloroacetate. Fundam Appl Toxicol. 1992;19:57–63
  11. Linder RE, Klinefelter GR, Strader LF, Suarez JD, Dyer CL. Acute spermatogenic effects of bromoacetic acids. Fundam Appl Toxicol. 1994;22:422–430
  12. Linder RE, Klinefelter GR, Strader LF, Suarez JD, Roberts NL, Dyer CJ. Spermatotoxicity of dibromoacetic acid in rats after 14 daily exposures. Reprod Toxicol. 1994;8:251–259
  13. Savitz DA, Singer PC, Hartmann KE, Herring AH, Weinberg HS, Makarushka CM, et al. Drinking water disinfection by-products and pregnancy outcome. Denver, CO: Awwa Research Foundation; 2005;
  14. Royster MO, Lobdell DT, Mendola P, Perreault SD, Selevan SG, Rothmann SA, et al. Evaluation of a container for collection and shipment of semen with potential uses in population-based, clinical, and occupational settings. J Androl. 2000;21:478–484
  15. Klinefelter GR, Laskey JW, Ferrell J, Suarez JD, Roberts NL. Discriminant analysis indicates a single sperm protein (SP22) is predictive of fertility following exposure to epididymal toxicants. J Androl. 1997;18:139–150
  16. Evenson D, Jost L. Sperm chromatin structure assay is useful for fertility assessment. Methods Cell Sci. 2000;22:169–189
  17. Sakkas D, Manicardi G, Bianchi PG, Bizzaro D, Bianchi U. Relationship between the presence of endogenous nicks and sperm chromatin packaging in maturing and fertilizing mouse spermatozoa. Biol Reprod. 1995;52:1149–1155
  18. Promislow JH, Makarushka CM, Gorman JR, Howards PP, Savitz DA, Hartmann KE. Recruitment for a community-based study of early pregnancy: the Right From The Start study. Paediatr Perinat Epidemiol. 2004;18:143–152
  19. Coughlin LB, McGuigan JR, Haddad NG. Social class and semen analysis. J Obstet Gynaecol. 2003;23:276–277
  20. Auger J, Eustache F, Andersen AG, Irvine DS, Jorgensen N, Skakkebaek NE, et al. Sperm morphological defects related to environment, lifestyle and medical history of 1001 male partners of pregnant women from four European cities. Hum Reprod. 2001;16:2710–2717

 Disclaimer: Although the research described in this article has been supported by the U.S. Environmental Protection Agency, it has not been subjected to Agency review and therefore does not necessarily reflect the views of the Agency, and no official endorsement should be inferred. Mention of trade names or commercial products does not constitute endorsement or recommendation for use.Supported in part by grants from the U.S. Environmental Protection Agency (R-82932701) and National Institute of Environmental Health Sciences (P30ES10126).

PII: S0015-0282(06)04027-1

doi: 10.1016/j.fertnstert.2006.07.1517

Fertility and Sterility
Volume 87, Issue 3 , Pages 554-564 , March 2007

Article Tools

* Image Usage & Resolution