Fertility and Sterility
Volume 87, Issue 3 , Pages 565-571 , March 2007

Abnormal progression through meiosis in men with nonobstructive azoospermia

  • Fei Sun, M.D., Ph.D.

      Affiliations

    • Department of Medical Genetics, University of Calgary, Calgary, Alberta, Canada
    • Department of Genetics, Alberta Children’s Hospital, Calgary, Alberta, Canada
    • ,
  • Paul Turek, M.D.

      Affiliations

    • Department of Urology, Obstetrics and Gynecology and Reproductive Sciences, University of California, San Francisco, California
    • ,
  • Calvin Greene, M.D.

      Affiliations

    • Department of Obstetrics and Gynecology, University of Calgary, Calgary, Alberta, Canada
    • ,
  • Evelyn Ko, B.Sc.

      Affiliations

    • Department of Genetics, Alberta Children’s Hospital, Calgary, Alberta, Canada
    • ,
  • Alfred Rademaker, Ph.D.

      Affiliations

    • Department of Preventive Medicine, Northwestern University Medical School, Chicago, Illinois
    • ,
  • Renée H. Martin, Ph.D.

      Affiliations

    • Department of Medical Genetics, University of Calgary, Calgary, Alberta, Canada
    • Department of Genetics, Alberta Children’s Hospital, Calgary, Alberta, Canada
    • Corresponding Author InformationReprint requests: Renée H. Martin, Ph.D., Department of Genetics, Alberta Children’s Hospital, 1820 Richmond Road S.W., Calgary, Alberta, Canada T2T 5C7 (FAX: 403-543-9100).

Received 4 May 2006 ,Revised 24 July 2006 ,Accepted 24 July 2006.

References 

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  6. Sun F, Trpkov K, Rademaker A, Ko E, Barclay L, Mikhaail-Philips M, et al. The effect of cold storage on recombination frequencies in human male testicular cells. Cytogenet Genome Res. 2004;106:39–42
  7. Gonsalves J, Sun F, Schlegal P, Hopps C, Turek P, Greene C, et al. Defective recombination in infertile men. Hum Mol Genet. 2004;13:2875–2883
  8. Sun F, Kozak G, Scott S, Trpkov K, Ko E, Mikhaail-Philips M, et al. Meiotic defects in a man with non-obstructive azoospermia: case report. Hum Reprod. 2004;19:1770–1773
  9. Sun F, Oliver-Bonet M, Liehr T, Starke H, Ko E, Rademaker A, et al. Human male recombination maps for individual chromosomes. Am J Hum Genet. 2004;74:521–531
  10. Sun F, Trpkov K, Rademaker A, Ko E, Martin RH. Variation in meiotic recombination frequencies among human males. Hum Genet. 2005;116:172–178
  11. Sun F, Greene C, Turek PJ, Ko E, Rademaker A, Martin RH. Immunofluorescent synaptonemal complex analysis in azoospermic men. Cytogenet Genome Res. 2005;111:366–370
  12. Codina-Pascual M, Oliver-Bonet M, Navarro J, Campillo M, Garcia F, Egozcue S, et al. Synapsis and meiotic recombination analyses: MLH1 focus in the XY pair as an indicator. Hum Reprod. 2005;20:2133–2139
  13. Solari AJ. Synaptosomal complexes and associated structures in microspread human spermatocytes. Chromosoma. 1980;81:315–337
  14. Sun F, Oliver-Bonet M, Liehr T, Starke H, Trpkov K, Ko E, et al. Discontinuities and unsynapsed regions in meiotic chromosomes have a cis effect on meiotic recombination patterns in normal human males. Hum Mol Genet. 2005;14:3013–3018
  15. Judis L, Chan ER, Schwartz S, Seftel A, Hassold T. Meiosis I arrest and azoospermia in an infertile male explained by failure of formation of a component of the synaptonemal complex. Fertil Steril. 2004;81:205–209
  16. Guichaoua MR, Perrin J, Metzler-Guillemain C, Saias-Magnan J, Giorgi R, Grillo JM. Meiotic anomalies in infertile men with severe spermatogenic defects. Hum Reprod. 2005;20:1897–1902
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  20. Koehler K, Hawley R, Sherman S, Hassold T. Recombination and nondisjunction in humans and flies. Hum Mol Genet. 1996;5:1495–1504
  21. Shi Q, Spriggs E, Field L, Ko E, Barclay L, Martin R. Single sperm typing demonstrates that reduced recombination is associated with the production of aneuploid 24,XY human sperm. Am J Med Genet. 2001;99:34–38
  22. Hassold T, Sherman S, Pettay D, Page D, Jacobs P. XY chromosome nondisjunction in man is associated with diminished recombination in the pseudoautosomal region. Am J Hum Genet. 1991;49:253–260
  23. Hale D. Is X-Y recombination necessary for spermatocyte survival during mammalian spermatogenesis?. Cytogenet Cell Genet. 1994;65:278–282
  24. Martin RH, Greene C, Rademaker A, Ko E, Chernos J. Analysis of aneuploidy in spermatozoa from testicular biopsies from men with nonobstructive azoospermia. J Androl. 2003;24:100–103
  25. Martin RH, Rademaker AW, Greene C, Ko E, Hoang T, Barclay L, et al. A comparison of the frequency of sperm chromosome abnormalities in men with mild, moderate, and severe oligozoospermia. Biol Reprod. 2003;69:535–539
  26. Ma S, Arsovska S, Moens P, Nigro M, Chow V. Analysis of early meiotic events and aneuploidy in nonobstructive azoospermic men: a preliminary report. Fertil Steril. 2006;85:646–652

 Supported by Canadian Institutes of Health Research grant (MA7961 to R.H.M.) and Canada Research Chair in Genetics (to R.H.M.).

PII: S0015-0282(06)04030-1

doi: 10.1016/j.fertnstert.2006.07.1531

Fertility and Sterility
Volume 87, Issue 3 , Pages 565-571 , March 2007

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