Fertility and Sterility
Volume 87, Issue 3 , Pages 597-602 , March 2007

Evaluation of an existing nomogram for predicting the response to clomiphene citrate

  • Cyrus Ghobadi, M.B., Ch.B.

      Affiliations

    • Academic Unit of Clinical Pharmacology, University of Sheffield, Sheffield, South Yorkshire, United Kingdom
    • Academic Unit of Reproductive and Developmental Medicine, University of Sheffield, Sheffield, South Yorkshire, United Kingdom
  • ,
  • Tien Huu Nguyen, M.D.

      Affiliations

    • Academic Unit of Clinical Pharmacology, University of Sheffield, Sheffield, South Yorkshire, United Kingdom
    • Academic Unit of Reproductive and Developmental Medicine, University of Sheffield, Sheffield, South Yorkshire, United Kingdom
  • ,
  • Martin S. Lennard, Ph.D.

      Affiliations

    • Academic Unit of Clinical Pharmacology, University of Sheffield, Sheffield, South Yorkshire, United Kingdom
    • Corresponding Author InformationReprint requests: Martin S. Lennard, Ph.D., Academic Unit of Clinical Pharmacology, Floor M, Royal Hallamshire Hospital, Sheffield, South Yorkshire, S10 2JF, United Kingdom.
  • ,
  • Saad Amer, M.D.

      Affiliations

    • Academic Unit of Reproductive and Developmental Medicine, University of Sheffield, Sheffield, South Yorkshire, United Kingdom
  • ,
  • Amin Rostami-Hodjegan, Ph.D.

      Affiliations

    • Academic Unit of Clinical Pharmacology, University of Sheffield, Sheffield, South Yorkshire, United Kingdom
  • ,
  • William L. Ledger, D.Phil.

      Affiliations

    • Academic Unit of Reproductive and Developmental Medicine, University of Sheffield, Sheffield, South Yorkshire, United Kingdom

Received 3 April 2006 ,Revised 18 August 2006 ,Accepted 5 October 2006.

References 

  1. Homburg R. Clomiphene citrate—end of an era? (A mini-review). Hum Reprod. 2005;20:2043–2051
  2. Imani B, Eijkemans MJ, te Velde ER, Habbema JD, Fauser BC. Predictors of patients remaining anovulatory during clomiphene citrate induction of ovulation in normogonadotropic oligoamenorrheic infertility. J Clin Endocrinol Metab. 1998;83:2361–2365
  3. Lambalk CB, Huirne JA, Macklon NS, Fauser BC, Homburg R. Ovulation induction with clomiphene or gonadotropins. International Congress Series. 2005;1279:16–23
  4. Rostami-Hodjegan A, Lennard MS, Tucker GT, Ledger WL. Monitoring plasma concentrations to individualize treatment with clomiphene citrate. Fertil Steril. 2004;81:1187–1193
  5. van Noord-Zaadstra BM, Looman CW, Alsbach H, Habbema JD, te Velde ER, Karbaat J. Delaying childbearing: effect of age on fecundity and outcome of pregnancy. BMJ. 1991;302:1361–1365
  6. Schwartz D, Mayaux MJ. Female fecundity as a function of age: results of artificial insemination in 2193 nulliparous women with azoospermic husbands. Federation CECOS. N Engl J Med. 1982;306:404–406
  7. de La Rochebrochard E, Thonneau P. Paternal age >or=40 years: an important risk factor for infertility. Am J Obstet Gynecol. 2003;189:901–905
  8. Imani B, Eijkemans MJ, te Velde ER, Habbema JD, Fauser BC. A nomogram to predict the probability of live birth after clomiphene citrate induction of ovulation in normogonadotropic oligoamenorrheic infertility. Fertil Steril. 2002;77:91–97
  9. Imani B, Eijkemans MJ, te Velde ER, Habbema JD, Fauser BC. Predictors of chances to conceive in ovulatory patients during clomiphene citrate induction of ovulation in normogonadotropic oligoamenorrheic infertility. J Clin Endocrinol Metab. 1999;84:1617–1622
  10. Davis S, Tran J. What are “normal” testosterone levels for women?. J Clin Endocrinol Metab. 2001;86:1842–1844
  11. Fletcher RH. Diagnosis. In:  Fletcher RH,  Fletcher SW,  Wagner EH editor. Clinical epidemiology: the essentials. Baltimore, MD: Williams and Wilkins; 1996;
  12. Jain T, Soules MR, Collins JA. Comparison of basal follicle-stimulating hormone versus the clomiphene citrate challenge test for ovarian reserve screening. Fertil Steril. 2004;82:180–185
  13. Greenhalgh T. How to read a paper (Papers that report diagnostic or screening tests). BMJ. 1997;315:540–543
  14. Harper R, Reeves B. Reporting of precision of estimates for diagnostic accuracy: a review. BMJ. 1999;318:1322–1323
  15. Expert Panel on the Identification, Evaluation, and Treatment of Overweight in Adults. Clinical guidelines on the identification, evaluation, and treatment of overweight and obesity in adults: executive summary. Am J Clin Nutr. 1998;68:899–917
  16. Ioannides-Demos LL, Proietto J, McNeil JJ. Pharmacotherapy for obesity. Drugs. 2005;65:1391–1418
  17. Sinha-Hikim I, Arver S, Beall G, Shen R, Guerrero M, Sattler F, et al. The use of a sensitive equilibrium dialysis method for the measurement of free testosterone levels in healthy, cycling women and in human immunodeficiency virus-infected women. J Clin Endocrinol Metab. 1998;83:1312–1318
  18. Tarlatzis BC, Grimbizis G. Future use of clomiphene in ovarian stimulation (Will clomiphene persist in the 21st century?). Hum Reprod. 1998;13:2356–2357
  19. Gorlitsky GA, Kase NG, Speroff L. Ovulation and pregnancy rates with clomiphene citrate. Obstet Gynecol. 1978;51:265–269
  20. Shepard MK, Balmaceda JP, Leija CG. Relationship of weight to successful induction of ovulation with clomiphene citrate. Fertil Steril. 1979;32:641–645
  21. Polson DW, Kiddy DS, Mason HD, Franks S. Induction of ovulation with clomiphene citrate in women with polycystic ovary syndrome: the difference between responders and nonresponders. Fertil Steril. 1989;51:30–34
  22. Kurabayashi T, Suzuki M, Fujita K, Murakawa H, Hasegawa I, Tanaka K. Prognostic factors for ovulatory response with clomiphene citrate in polycystic ovary syndrome. Eur J Obstet Gynecol Reprod Biol. 2006;126:201–205
  23. Zweig MH, Campbell G. Receiver-operating characteristic (ROC) plots: a fundamental evaluation tool in clinical medicine. Clin Chem. 1993;39:561–577
  24. Jaeschke R, Guyatt G, Sackett DL Evidence-Based Medicine Working Group. Users’ guides to the medical literature. III. How to use an article about a diagnostic test. A. Are the results of the study valid?. JAMA. 1994;271:389–391
  25. Jaeschke R, Guyatt GH, Sackett DL The Evidence-Based Medicine Working Group. Users’ guides to the medical literature. III. How to use an article about a diagnostic test. B. What are the results and will they help me in caring for my patients?. JAMA. 1994;271:703–707
  26. Gysler M, March CM, Mishell DR, Bailey EJ. A decade’s experience with an individualized clomiphene treatment regimen including its effect on the postcoital test. Fertil Steril. 1982;37:161–167
  27. Lobo RA, Gysler M, March CM, Goebelsmann U, Mishell DR. Clinical and laboratory predictors of clomiphene response. Fertil Steril. 1982;37:168–174
  28. Wolf LJ. Ovulation induction. Clin Obstet Gynecol. 2000;43:902–915
  29. Balen A. The pathophysiology of polycystic ovary syndrome: trying to understand PCOS and its endocrinology. Best Pract Res Clin Obstet Gynaecol. 2004;18:685–706
  30. Purvin VA. Visual disturbance secondary to clomiphene citrate. Arch Ophthalmol. 1995;113:482–484
  31. Roch LM, Gordon DL, Barr AB, Paulsen CA. Visual changes associated with clomiphene citrate therapy. Arch Ophthalmol. 1967;77:14–17
  32. Siedentopf F, Horstkamp B, Stief G, Kentenich H. Clomiphene citrate as a possible cause of a psychotic reaction during infertility treatment. Hum Reprod. 1997;12:706–707
  33. Kousta E, White DM, Franks S. Modern use of clomiphene citrate in induction of ovulation. Hum Reprod Update. 1997;3:359–365
  34. Sovino H, Sir-Petermann T, Devoto L. Clomiphene citrate and ovulation induction. Reprod Biomed Online. 2002;4:303–310

PII: S0015-0282(06)04214-2

doi: 10.1016/j.fertnstert.2006.10.002

Fertility and Sterility
Volume 87, Issue 3 , Pages 597-602 , March 2007