Fertility and Sterility
Volume 87, Issue 6 , Pages 1333-1339 , June 2007

Oocyte aneuploidy mechanisms are different in two situations of increased chromosomal risk: older patients and patients with recurrent implantation failure after in vitro fertilization

  • François Vialard, Pharm.D.

      Affiliations

    • Departments of Reproductive Biology, Cytogenetics, Gynaecology, and Obstetrics, Centre Hospitalier Intercommunal de Poissy St-Germain 78, Poissy, France
    • Institut National de la Santé et de la Recherche Médicale U407, 69 Oullins, France
    • Corresponding Author InformationReprint requests: François Vialard, Pharm.D., CHI Poissy Saint Germain, Department of Reproductive Biology, Cytogenetics, Gynaecology, and Obstetrics, 10 Rue du Champs Gaillard, 78303 Poissy, France (FAX: 33-1-39-27-44-25).
  • ,
  • R. Lombroso, M.D.

      Affiliations

    • Departments of Reproductive Biology, Cytogenetics, Gynaecology, and Obstetrics, Centre Hospitalier Intercommunal de Poissy St-Germain 78, Poissy, France
  • ,
  • M. Bergere, M.D., Ph.D.

      Affiliations

    • Departments of Reproductive Biology, Cytogenetics, Gynaecology, and Obstetrics, Centre Hospitalier Intercommunal de Poissy St-Germain 78, Poissy, France
    • Institut National de la Santé et de la Recherche Médicale U407, 69 Oullins, France
  • ,
  • D. Molina Gomes, M.D., Ph.D.

      Affiliations

    • Departments of Reproductive Biology, Cytogenetics, Gynaecology, and Obstetrics, Centre Hospitalier Intercommunal de Poissy St-Germain 78, Poissy, France
  • ,
  • I. Hammoud, M.D.

      Affiliations

    • Departments of Reproductive Biology, Cytogenetics, Gynaecology, and Obstetrics, Centre Hospitalier Intercommunal de Poissy St-Germain 78, Poissy, France
  • ,
  • M. Bailly, M.D.

      Affiliations

    • Departments of Reproductive Biology, Cytogenetics, Gynaecology, and Obstetrics, Centre Hospitalier Intercommunal de Poissy St-Germain 78, Poissy, France
  • ,
  • J. Selva, M.D., Ph.D.

      Affiliations

    • Departments of Reproductive Biology, Cytogenetics, Gynaecology, and Obstetrics, Centre Hospitalier Intercommunal de Poissy St-Germain 78, Poissy, France
    • Institut National de la Santé et de la Recherche Médicale U407, 69 Oullins, France

Received 7 April 2006 ,Revised 11 October 2006 ,Accepted 7 November 2006.

References 

  1. Griffin DK. The incidence, origin, and etiology of aneuploidy. Int Rev Cytol. 1996;167:263–296
  2. Boue JG, Boue A. Chromosomal anomalies in early spontaneous abortion ((Their consequences on early embryogenesis and in vitro growth of embryonic cells)). Curr Top Pathol. 1976;62:193–208
  3. Hassold T, Abruzzo M, Adkins K, Griffin D, Merrill M, Millie E, et al. Human aneuploidy: incidence, origin, and etiology. Environ Mol Mutagen. 1996;28:167–175
  4. Pellestor F. Frequency and distribution of aneuploidy in human female gametes. Hum Genet. 1991;86:283–288
  5. Hassold T, Hunt P. To err (meiotically) is human: the genesis of human aneuploidy. Nat Rev Genet. 2001;2:280–291
  6. Pellestor F, Andreo B, Arnal F, Humeau C, Demaille J. Maternal aging and chromosomal abnormalities: new data drawn from in vitro unfertilized human oocytes. Hum Genet. 2003;112:195–203
  7. Verlinsky Y, Cieslak J, Ivakhnenko V, Evsikov S, Wolf G, White M, et al. Prevention of age-related aneuploidies by polar body testing of oocytes. J Assist Reprod Genet. 1999;16:165–169
  8. Kahraman S, Bahce M, Samli H, Imirzalioglu N, Yakisn K, Cengiz G, et al. Healthy births and ongoing pregnancies obtained by preimplantation genetic diagnosis in patients with advanced maternal age and recurrent implantation failure. Hum Reprod. 2000;15:2003–2007
  9. Gianaroli L, Magli MC, Ferraretti AP, Tabanelli C, Trombetta C, Boudjema E. The role of preimplantation diagnosis for aneuploidies. Reprod Biomed Online. 2002;4(Suppl 3):31–36
  10. Pehlivan T, Rubio C, Rodrigo L, Remohi J, Pellicer A, Simon C. Preimplantation genetic diagnosis by fluorescence in situ hybridization: clinical possibilities and pitfalls. J Soc Gynecol Investig. 2003;10:315–322
  11. Kahraman S, Benkhalifa M, Donmez E, Biricik A, Sertyel S, Findikli N, et al. The results of aneuploidy screening in 276 couples undergoing assisted reproductive techniques. Prenat Diagn. 2004;24:307–311
  12. Gianaroli L, Magli MC, Ferraretti AP, Munne S. Preimplantation diagnosis for aneuploidies in patients undergoing in vitro fertilization with a poor prognosis: identification of the categories for which it should be proposed. Fertil Steril. 1999;72:837–844
  13. Sermon K, Moutou C, Harper J, Geraedts J, Scriven P, Wilton L, et al. ESHRE PGD Consortium data collection IV: May-December 2001. Hum Reprod. 2005;20:19–34
  14. Munne S, Sandalinas M, Magli C, Gianaroli L, Cohen J, Warburton D. Increased rate of aneuploid embryos in young women with previous aneuploid conceptions. Prenat Diagn. 2004;24:638–643
  15. Vialarde F, Petit C, Bergere M, Molina Gomes D, Petit-Martel V, Lombroso R, et al. Evidence of a high proportion of unbalanced premature sister chromatid separation in the first polar bodies of women of advanced age. Hum Reprod. 2006;21:1172–1178
  16. Angell RR. Predivision in human oocytes at meiosis I: a mechanism for trisomy formation in man. Hum Genet. 1991;86:383–387
  17. Munne S, Dailey T, Sultan KM, Grifo J, Cohen J. The use of first polar bodies for preimplantation diagnosis of aneuploidy. Hum Reprod. 1995;10:1014–1020
  18. Los FJ, Van Opstal D, van den Berg C. The development of cytogenetically normal, abnormal and mosaic embryos: a theoretical model. Hum Reprod Update. 2004;10:79–94
  19. Daphnis DD, Delhanty JD, Jerkovic S, Geyer J, Craft I, Harper JC. Detailed FISH analysis of day 5 human embryos reveals the mechanisms leading to mosaic aneuploidy. Hum Reprod. 2005;20:129–137
  20. Delhanty JD, Harper JC, Ao A, Handyside AH, Winston RM. Multicolour FISH detects frequent chromosomal mosaicism and chaotic division in normal preimplantation embryos from fertile patients. Hum Genet. 1997;99:755–760
  21. Harper JC, Coonen E, Handyside AH, Winston RM, Hopman AH, Delhanty JD. Mosaicism of autosomes and sex chromosomes in morphologically normal, monospermic preimplantation human embryos. Prenat Diagn. 1995;15:41–49
  22. Munne S, Morrison L, Fung J, Marquez C, Weier U, Bahce M, et al. Spontaneous abortions are reduced after preconception diagnosis of translocations. J Assist Reprod Genet. 1998;15:290–296
  23. Laverge H, De Sutter P, Verschraegen-Spae MR, De Paepe A, Dhont M. Triple colour fluorescent in-situ hybridization for chromosomes X,Y and 1 on spare human embryos. Hum Reprod. 1997;12:809–814
  24. Voullaire L, Slater H, Williamson R, Wilton L. Chromosome analysis of blastomeres from human embryos by using comparative genomic hybridization. Hum Genet. 2000;106:210–217
  25. Wells D, Delhanty JD. Comprehensive chromosomal analysis of human preimplantation embryos using whole genome amplification and single cell comparative genomic hybridization. Mol Hum Reprod. 2000;6:1055–1062
  26. Baart EB, Martini E, van den Berg I, Macklon NS, Galjaard RJ, Fauser BC, et al. Preimplantation genetic screening reveals a high incidence of aneuploidy and mosaicism in embryos from young women undergoing IVF. Hum Reprod. 2006;21:223–233
  27. FIVNAT website. Available at: http://perso.wanadoo.fr/fivnat.fr/.
  28. Kuliev A, Cieslak J, Ilkevitch Y, Verlinsky Y. Chromosomal abnormalities in a series of 6,733 human oocytes in preimplantation diagnosis for age-related aneuploidies. Reprod Biomed Online. 2003;6:54–59
  29. Montag M, van der Ven K, Dorn C, van der Ven H. Outcome of laser-assisted polar body biopsy and aneuploidy testing. Reprod Biomed Online. 2004;9:425–429
  30. Pellestor F, Andreo B, Arnal F, Humeau C, Demaille J. Mechanisms of non-disjunction in human female meiosis: the co-existence of two modes of malsegregation evidenced by the karyotyping of 1397 in-vitro unfertilized oocytes. Hum Reprod. 2002;17:2134–2145
  31. Verlinsky Y, Cieslak J, Ivakhnenko V, Evsikov S, Wolf G, White M, et al. Chromosomal abnormalities in the first and second polar body. Mol Cell Endocrinol. 2001;183(Suppl 1):S47–S49
  32. Delhanty JD. Mechanisms of aneuploidy induction in human oogenesis and early embryogenesis. Cytogenet Genome Res. 2005;111:237–244
  33. Kuliev A, Cieslak J, Verlinsky Y. Frequency and distribution of chromosome abnormalities in human oocytes. Cytogenet Genome Res. 2005;111:193–198
  34. Gutierrez-Mateo C, Benet J, Wells D, Colls P, Bermudez MG, Sanchez-Garcia JF, et al. Aneuploidy study of human oocytes first polar body comparative genomic hybridization and metaphase II fluorescence in situ hybridization analysis. Hum Reprod. 2004;19:2859–2868
  35. Cupisti S, Conn CM, Fragouli E, Whalley K, Mills JA, Faed MJ, et al. Sequential FISH analysis of oocytes and polar bodies reveals aneuploidy mechanisms. Prenat Diagn. 2003;23:663–668
  36. Pujol A, Boiso I, Benet J, Veiga A, Durban M, Campillo M, et al. Analysis of nine chromosome probes in first polar bodies and metaphase II oocytes for the detection of aneuploidies. Eur J Hum Genet. 2003;11:325–336
  37. Angell R. Mechanism of chromosome nondisjunction in human oocytes. Prog Clin Biol Res. 1995;393:13–26
  38. Angell R. First-meiotic-division nondisjunction in human oocytes. Am J Hum Genet. 1997;61:23–32
  39. Mahmood R, Brierley CH, Faed MJ, Mills JA, Delhanty JD. Mechanisms of maternal aneuploidy: FISH analysis of oocytes and polar bodies in patients undergoing assisted conception. Hum Genet. 2000;106:620–626
  40. Nakaoka Y, Okamoto E, Miharu N, Ohama K. Chromosome analysis in human oocytes remaining unfertilized after in-vitro insemination: effect of maternal age and fertilization rate. Hum Reprod. 1998;13:419–424
  41. Ledee-Bataille N, Bonnet-Chea K, Hosny G, Dubanchet S, Frydman R, Chaouat G. Role of the endometrial tripod interleukin-18, -15, and -12 in inadequate uterine receptivity in patients with a history of repeated in vitro fertilization-embryo transfer failure. Fertil Steril. 2005;83:598–605

 This study was sponsored, in part, by Serono, Inc.

PII: S0015-0282(06)04486-4

doi: 10.1016/j.fertnstert.2006.11.042

Fertility and Sterility
Volume 87, Issue 6 , Pages 1333-1339 , June 2007