Fertility and Sterility
Volume 88, Issue 1 , Pages 240-243 , July 2007

The effect of cinnamon extract on insulin resistance parameters in polycystic ovary syndrome: a pilot study

Presented at the ASRM 62nd Annual Meeting, New Orleans, Louisiana, October 21, 2006.

  • Jeff G. Wang, M.D.

      Affiliations

    • Department of Obstetrics & Gynecology, Division of Reproductive Endocrinology, College of Physicians & Surgeons, Columbia University, New York, New York
    • Corresponding Author InformationReprint requests: Jeff Wang, M.D., Department of Obstetrics & Gynecology, Columbia University, 622 W. 168th Street PH-16, New York, NY 10023 (FAX: 212-305.4326).
    • ,
  • Richard A. Anderson, Ph.D.

      Affiliations

    • US Department of Agriculture, Agriculture Research Service, Beltsville Human Nutrition Research Center, Beltsville, Maryland
    • ,
  • George M. Graham III, M.D.

      Affiliations

    • Department of Obstetrics and Gynecology, John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii
    • ,
  • Micheline C. Chu, M.D.

      Affiliations

    • Department of Obstetrics & Gynecology, Division of Reproductive Endocrinology, College of Physicians & Surgeons, Columbia University, New York, New York
    • ,
  • Mark V. Sauer, M.D.

      Affiliations

    • Department of Obstetrics & Gynecology, Division of Reproductive Endocrinology, College of Physicians & Surgeons, Columbia University, New York, New York
    • ,
  • Michael M. Guarnaccia, M.D.

      Affiliations

    • Department of Obstetrics & Gynecology, Division of Reproductive Endocrinology, College of Physicians & Surgeons, Columbia University, New York, New York
    • ,
  • Rogerio A. Lobo, M.D.

      Affiliations

    • Department of Obstetrics & Gynecology, Division of Reproductive Endocrinology, College of Physicians & Surgeons, Columbia University, New York, New York

Received 27 July 2006 ,Revised 1 November 2006 ,Accepted 16 November 2006.

References 

  1. Franks S. Polycystic ovary syndrome. N Engl J Med. 1995;333:853–861
  2. Rotterdam . Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS). In: ROTTERDAM ESHRE ASRM-sponsored PCOS consensus workshop group. 2004;Rotterdam 41–7
  3. Rotterdam . Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS). In: ROTTERDAM ESHRE ASRM-sponsored PCOS consensus workshop group. 2004;p. 19–25Rotterdam
  4. Dunaif A. Insulin resistance and the polycystic ovary syndrome: mechanism and implications for pathogenesis. Endocrinol Rev. 1997;18:774–800
  5. Carmina E, Lobo RA. Use of fasting blood to assess the prevalence of insulin resistance in women with polycystic ovary syndrome. Fertil Steril. 2004;82:661–665
  6. Nestler JE, Jakubowicz DJ, de Vargas AF, Brik C, Quintero N, Medina F. Insulin stimulates testosterone biosynthesis by human thecal cells from women with polycystic ovary syndrome by activating its own receptor and using inositolglycan mediators as the signal transduction system. J Clin Endocrinol Metab. 1998;83:2001–2005
  7. Azziz R. Androgen excess is the key element in polycystic ovary syndrome. Fertil Steril. 2003;80:252–254
  8. Legro RS, Myers ER, Schlaff WD, Carr BR, Diamond MP. Improvement in live births with clomiphene citrate and metformin, alone and in combination, in infertile women with polycystic ovary syndrome. Fertil Steril. 2006;86:S1
  9. Lord JM, Flight IH, Norman RJ. Metformin in polycystic ovary syndrome: systematic review and meta-analysis. BMJ. 2003;327:951–953
  10. Haas DA, Carr BR, Attia GR. Effects of metformin on body mass index, menstrual cyclicity, and ovulation induction in women with polycystic ovary syndrome. Fertil Steril. 2003;79:469–481
  11. Costello MF, Eden JA. A systematic review of the reproductive system effects of metformin in patients with polycystic ovary syndrome. Fertil Steril. 2003;79:1–13
  12. Cataldo NA, Abbasi F, McLaughlin TL, Basina M, Fechner PY, Giudice LC, et al. Metabolic and ovarian effects of rosiglitazone treatment for 12 weeks in insulin-resistant women with polycystic ovary syndrome. Hum Reprod. 2006;21:109–120
  13. Cataldo NA, Abbasi F, McLaughlin TL, Lamendola C, Reaven GM. Improvement in insulin sensitivity followed by ovulation and pregnancy in a woman with polycystic ovary syndrome who was treated with rosiglitazone. Fertil Steril. 2001;76:1057–1059
  14. Rautio K, Tapanainen JS, Ruokonen A, Morin-Papunen LC. Endocrine and metabolic effects of rosiglitazone in overweight women with PCOS: a randomized placebo-controlled study. Hum Reprod. 2006;21:1400–1407
  15. Eisenhardt S, Schwarzmann N, Henschel V, Germeyer A, von Wolff M, Hamann A, et al. Early effects of metformin in women with polycystic ovary syndrome: a prospective randomized, double-blind, placebo-controlled trial. J Clin Endocrinol Metab. 2006;91:946–952
  16. Anderson RA, Broadhurst CL, Polansky MM, Schmidt WF, Khan A, Flanagan VP, et al. Isolation and characterization of polyphenol type-A polymers from cinnamon with insulin-like biological activity. J Agric Food Chem. 2004;52:65–70
  17. Jarvill-Taylor KJ, Anderson RA, Graves DJ. A hydroxychalcone derived from cinnamon functions as a mimetic for insulin in 3T3-L1 adipocytes. J Am Coll Nutr. 2001;20:327–336
  18. Qin B, Nagasaki M, Ren M, Bajotto G, Oshida Y, Sato Y. Cinnamon extract prevents the insulin resistance induced by a high-fructose diet. Horm Metab Res. 2004;36:119–125
  19. Qin B, Nagasaki M, Ren M, Bajotto G, Oshida Y, Sato Y. Cinnamon extract (traditional herb) potentiates in vivo insulin-regulated glucose utilization via enhancing insulin signaling in rats. Diabetes Res Clin Pract. 2003;62:139–148
  20. Khan A, Safdar M, Ali Khan MM, Khattak KN, Anderson RA. Cinnamon improves glucose and lipids of people with type 2 diabetes. Diabetes Care. 2003;26:3215–3218
  21. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985;28:412–419
  22. Katz A, Nambi SS, Mather K, Baron AD, Follmann DA, Sullivan G, et al. Quantitative insulin sensitivity check index: a simple, accurate method for assessing insulin sensitivity in humans. J Clin Endocrinol Metab. 2000;85:2402–2410
  23. Genuth S, Alberti KG, Bennett P, Buse J, Defronzo R, Kahn R, et al. Follow-up report on the diagnosis of diabetes mellitus. Diabetes Care. 2003;26:3160–3167
  24. Matsuda M, DeFronzo RA. Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp. Diabetes Care. 1999;22:1462–1470

PII: S0015-0282(06)04555-9

doi: 10.1016/j.fertnstert.2006.11.082

Fertility and Sterility
Volume 88, Issue 1 , Pages 240-243 , July 2007

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