Fertility and Sterility
Volume 88, Issue 6 , Pages 1541-1547 , December 2007

Hormonal suppression treatment or dietary therapy versus placebo in the control of painful symptoms after conservative surgery for endometriosis stage III–IV. A randomized comparative trial

  • Francesco Sesti, M.D.

      Affiliations

    • Endometriosis Center, Section of Gynecology & Obstetrics, Department of Surgery, Tor Vergata University Hospital, Rome, Italy
    • Corresponding Author InformationReprint requests: Francesco Sesti, M.D., Section of Gynaecology and Obstetrics, Department of Surgery, School of Medicine, “Tor Vergata” University Hospital, Viale Oxford 81, 00133 Rome, Italy (FAX: +39.06.20.902.921).
    • ,
  • Adalgisa Pietropolli, M.D.

      Affiliations

    • Endometriosis Center, Section of Gynecology & Obstetrics, Department of Surgery, Tor Vergata University Hospital, Rome, Italy
    • ,
  • Talia Capozzolo, M.D.

      Affiliations

    • Endometriosis Center, Section of Gynecology & Obstetrics, Department of Surgery, Tor Vergata University Hospital, Rome, Italy
    • ,
  • Patrizia Broccoli, M.D.

      Affiliations

    • Endometriosis Center, Section of Gynecology & Obstetrics, Department of Surgery, Tor Vergata University Hospital, Rome, Italy
    • ,
  • Silvia Pierangeli, Ph.D.

      Affiliations

    • Section of Clinical Nutrition, Department of Internal Medicine, Tor Vergata University Hospital, Rome, Italy
    • ,
  • Maria Rosa Bollea, M.D.

      Affiliations

    • Section of Clinical Nutrition, Department of Internal Medicine, Tor Vergata University Hospital, Rome, Italy
    • ,
  • Emilio Piccione, M.D.

      Affiliations

    • Endometriosis Center, Section of Gynecology & Obstetrics, Department of Surgery, Tor Vergata University Hospital, Rome, Italy

References 

  1. Guzick DS. Clinical epidemiology of endometriosis and infertility. Obstet Gynecol Clin North Am. 1989;16:43–59
  2. Parazzini F, Luchini L, Vezzoli F, Mezzanotte C, Vercellini P, Romanini C. Prevalence and anatomical distribution of endometriosis in women with selected gynaecological conditions: results from a multicentric Italian study. Hum Reprod. 1994;6:1158–1162
  3. Garry R, Clayton R, Hawe J. The effect of endometriosis and its radical laparoscopic excision on quality of life indicators. Br J Obstet Gynecol. 2000;107:44–54
  4. Fauconnier A, Chapron C. Endometriosis and pelvic pain: epidemiological evidence of the relationship and implications. Hum Reprod Update. 2005;11:595–606
  5. Chopin N, Vieira M, Borghese B, Foulot H, Dousset B, Coste J, et al. Operative management of deeply infiltrating endometriosis: results on pelvic pain symptoms according to a surgical classification. J Minim Invasive Gynecol. 2005;12:106–112
  6. Abbott JA, Hawe J, Clayton RD, Garry R. The effects and effectiveness of laparoscopic excision of endometriosis: a prospective study with 2-5 year follow-up. Hum Reprod. 2003;18:1922–1927
  7. Vercellini P, Crosignani PG, Fadini R, Radici E, Belloni C, Sismondi P. A gonadotrophin-releasing hormone agonist compared with expectant management after conservative surgery for symptomatic endometriosis. Br J Obstet Gynaecol. 1999;106:672–677
  8. Kennedy S, Bergquist A, Chapron C, D'Hooghe T, Dunselman G, Greb R, et al. on behalf of the ESHRE Special Interest Group for Endometriosis and Endometrium Guideline Development Group. ESHRE guideline for the diagnosis and treatment of endometriosis. Hum Reprod. 2005;20:2698–2704
  9. Busacca M, Somigliana E, Bianchi S, De Marinis S, Calia C, Candiani M, et al. Post-operative GnRH analogue treatment after conservative surgery for symptomatic endometriosis stage III–IV: a randomized controlled trial. Hum Reprod. 2001;16:2399–2402
  10. Yap C, Furness S, Farquhar C. Pre and post operative medical therapy for endometriosis surgery (review). Cochrane Database Syst Rev. 2004;3:CD003678
  11. Proctor ML, Murphy PA. Herbal and dietary therapies for primary and secondary dysmenorrhoea (review). Cochrane Database Syst Rev. 2001;2:CD002124
  12. Halliwell B, Gutteridge JM. Role of free radicals and catalytic metal ions in human disease: an overview. Methods Enzymol. 1990;186:1–85
  13. Jackson LW, Schisterman EF, Dey-Rao R, Browne R, Armstrong D. Oxidative stress and endometriosis. Hum Reprod. 2005;20:2014–2020
  14. Shanti A, Santanam N, Morales AJ, Parthasarathy S, Murphy AA. Autoantibodies to markers of oxidative stress are elevated in women with endometriosis. Fertil Steril. 1999;71:1115–1118
  15. Van Langendonckt A, Casanas-Roux F, Donnez J. Oxidative stress and peritoneal endometriosis. Fertil Steril. 2002;77:861–870
  16. Foyouzi N, Berkkanoglu M, Arici A, Kwintkiewicz J, Izquierdo D, Duleba AJ. Effects of oxidants and antioxidants on proliferation of endometrial stromal cells. Fertil Steril. 2004;82:S3;1019–22
  17. Gazvani MR, Smith L, Haggarty P, Fowler PA, Templeton A. High omega-3: omega-6 fatty acid ratios in culture medium reduce endometrial-cell survival in combined endometrial gland and stromal cell cultures from women with and without endometriosis. Fertil Steril. 2001;76:717–722
  18. Revised American Fertility Society Classification of Endometriosis . American Fertility Society. Fertil Steril. 1985;43:351–352
  19. Huskisson EE. Visual analogue scales. Pain measurement and assessment. New York: Raven Press; 1983;33–7
  20. McHorney CA, Ware JE, Raczek AE. The MOS 36-Item Short Form Health Survey (SF-36): II. Psychometric and clinical tests of validity in measuring physical and mental health constructs. Med Care. 1993;31:247–263
  21. Crosignani PG, Vercellini P, Biffignandi F, Costantini W, Cortesi I, Imparato E. Laparoscopy versus laparotomy in conservative surgical treatment for severe endometriosis. Fertil Steril. 1996;66:706–711
  22. Thomas EJ. Combining medical and surgical treatment for endometriosis: the best of both worlds?. Br J Obstet Gynecol. 1992;99(Suppl 7):5–8
  23. Parazzini F, Di Cintio E, Chatenoud L, Moroni S, Ardovino I, Struzziero E, et al. Estroprogestin vs. gonadotrophin agonists plus estroprogestin in the treatment of endometriosis-related pelvic pain: a randomized trial. Eur J Obstet Gynecol Reprod Biol. 2000;88:11–14
  24. Bianchi S, Busacca M, Agnoli B, Candiani M, Calia C, Vignali M. Effects of 3 months therapy with danazol after laparoscopic surgery for stage III/IV endometriosis: a randomized study. Hum Reprod. 1999;14:1335–1337
  25. Loverro G, Santillo V, Pansini MV, Lorusso F, Depalo R, Selvaggi L. Are GnRH agonists helpful in the therapy of endometriosis after surgical treatment?. Hum Reprod. 2001;16(Suppl 1):96
  26. Muzii L, Marana R, Caruana P, Catalano GF, Margutti F, Panici PB. Postoperative administration of monophasic combined oral contraceptives after laparoscopic treatment of ovarian endometriomas: a prospective, randomized trial. Am J Obstet Gynecol. 2000;183:588–592
  27. Hornstein MD, Hemmings R, Yuzpe AA, Heinrichs WL. Use of nafarelin versus placebo after reductive laparoscopic surgery for endometriosis. Fertil Steril. 1997;68:860–864
  28. Vercellini P, Trespidi L, Colombo A, Ventola N, Marchini M, Crosignani PG. A gonadotrophin releasing hormone agonist versus a low-dose oral contraceptive for pelvic pain associated with endometriosis. Fertil Steril. 1993;60:75–79
  29. The American College of Obstetricians and Gynecologists. Clinical management guidelines for obstetrician-gynecologists. Medical management of endometriosis. ACOG practice bulletin no. 11. Washington, DC: ACOG Publications; 1999;
  30. Ziaei S, Zakeri M, Kazemnejad A. A randomized controlled trial of vitamin E in the treatment of primary dysmenorrhoea. Br J Obstet Gynecol. 2005;112:466–469
  31. Harel Z, Biro FM, Kottenhahn RK, Rosenthal SL. Supplementation with omega-3 polyunsaturated fatty acids in the management of dysmenorrhea in adolescents. Am J Obstet Gynecol. 1996;174:1335–1338

PII: S0015-0282(07)00202-6

doi: 10.1016/j.fertnstert.2007.01.053

Fertility and Sterility
Volume 88, Issue 6 , Pages 1541-1547 , December 2007

Article Tools

* Image Usage & Resolution