Fertility and Sterility
Volume 88, Issue 6 , Pages 1692-1696, December 2007

Effectiveness of intrauterine insemination in subfertile couples with an isolated cervical factor: a randomized clinical trial

  • Pieternel Steures, M.D.

      Affiliations

    • Department of Obstetrics and Gynecology, Vrije Universiteit Medical Center, Amsterdam, the Netherlands
    • Center for Reproductive Medicine Academic Medical Center, Amsterdam, the Netherlands
    • Department of Public Health, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands
    • Corresponding Author InformationReprint requests: Pieternel Steures, M.D., Centre of Reproductive Medicine, Room H4-213, Department of Obstetrics and Gynecology, Academic Medical Centre, Meibergdreef 9, 1105 AZ Amsterdam, the Netherlands (FAX: 31-20-6963489).
    • ,
  • Jan Willem van der Steeg, M.D.

      Affiliations

    • Department of Obstetrics and Gynecology, Vrije Universiteit Medical Center, Amsterdam, the Netherlands
    • Center for Reproductive Medicine Academic Medical Center, Amsterdam, the Netherlands
    • Department of Public Health, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands
    • ,
  • Peter G.A. Hompes, M.D., Ph.D.

      Affiliations

    • Department of Obstetrics and Gynecology, Vrije Universiteit Medical Center, Amsterdam, the Netherlands
    • ,
  • Patrick M.M. Bossuyt, Ph.D.

      Affiliations

    • Department of Clinical Epidemiology and Biostatistics, Academic Medical Center, Amsterdam, the Netherlands
    • ,
  • J. Dik F. Habbema, Ph.D.

      Affiliations

    • Department of Public Health, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands
    • ,
  • Marinus J.C. Eijkemans, Ph.D.

      Affiliations

    • Department of Public Health, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands
    • ,
  • Willem A. Schöls, M.D.

      Affiliations

    • Department of Obstetrics and Gynecology, Meander Medical Center, Amersfoort, the Netherlands
    • ,
  • Jan M. Burggraaff, M.D.

      Affiliations

    • Department of Obstetrics and Gynecology, Scheperziekenhuis, Emmen, the Netherlands
    • ,
  • Fulco van der Veen, M.D., Ph.D.

      Affiliations

    • Center for Reproductive Medicine Academic Medical Center, Amsterdam, the Netherlands
    • ,
  • Ben W.J. Mol, M.D., Ph.D.

      Affiliations

    • Center for Reproductive Medicine Academic Medical Center, Amsterdam, the Netherlands
    • Department of Obstetrics and Gynecology, Máxima Medical Center, Veldhoven, the Netherlands
    • ,
  • CECERM (Collaborative Effort for Clinical Evaluation in Reproductive Medicine)

Received 24 July 2006; received in revised form 22 January 2007; accepted 22 January 2007. published online 08 May 2007.

After randomization of subfertile couples with an isolated cervical factor to intrauterine insemination for 6 months or expectant management for 6 months, 26 women (51%) vs. 16 women (33%) conceived, respectively. Of these pregnancies, 22 (43%) vs. 13 (27%) were ongoing (relative risk, 1.6; 95% confidence interval, 0.91 to 2.8). There was one multiple pregnancy in the group that was allocated to intrauterine insemination. This trial suggests a beneficial effect of IUI in couples with an isolated cervical factor.

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 This randomized controlled trial is registered in the Dutch Trial Register and as an International Standard Randomized Clinical Trial (ISRCTN63217062).

 Supported by grant 945-12-002 from ZonMw, the Netherlands Organization for Health Research and Development, the Hague, the Netherlands.

 Presented orally at the Conjoint Annual Meeting of the American Society for Reproductive Medicine and the Canadian Fertility and Andrology Society, ASRM/CFAS 2005 Montreal, Quebec, Canada, October 15–19, 2005.

PII: S0015-0282(07)00238-5

doi:10.1016/j.fertnstert.2007.01.124

Fertility and Sterility
Volume 88, Issue 6 , Pages 1692-1696, December 2007

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