Fertility and Sterility
Volume 88, Issue 6 , Pages 1534-1540 , December 2007

Characterization of WNT7A expression in human endometrium and endometriotic lesions

  • Regine Gaetje, M.D.

      Affiliations

    • Department of Obstetrics and Gynecology, Johann Wolfgang Goethe-University, Frankfurt, Germany
    • Corresponding Author InformationReprint requests: Regine Gaetje, M.D., Department of Obstetrics and Gynecology, Johann Wolfgang Goethe-University, Theodor Stern-Kai 7, 60596 Frankfurt, Germany (FAX: +49-69-6301-7034).
    • ,
  • Uwe Holtrich, Ph.D.

      Affiliations

    • Department of Obstetrics and Gynecology, Johann Wolfgang Goethe-University, Frankfurt, Germany
    • ,
  • Thomas Karn, Ph.D.

      Affiliations

    • Department of Obstetrics and Gynecology, Johann Wolfgang Goethe-University, Frankfurt, Germany
    • ,
  • Eva Cikrit

      Affiliations

    • Department of Obstetrics and Gynecology, Johann Wolfgang Goethe-University, Frankfurt, Germany
    • ,
  • Knut Engels, M.D.

      Affiliations

    • Department of Pathology, Johann Wolfgang Goethe-University, Frankfurt, Germany
    • ,
  • Achim Rody, M.D.

      Affiliations

    • Department of Obstetrics and Gynecology, Johann Wolfgang Goethe-University, Frankfurt, Germany
    • ,
  • Manfred Kaufmann, M.D.

      Affiliations

    • Department of Obstetrics and Gynecology, Johann Wolfgang Goethe-University, Frankfurt, Germany

Received 3 November 2006 ,Revised 26 January 2007 ,Accepted 26 January 2007.

References 

  1. Parr BA, McMahon AP. Sexually dimorphic development of the mammalian reproductive tract requires WNT-7A. Nature. 1998;395:707–710
  2. Miller C, Sassoon DA. Wnt7a maintains appropriate uterine patterning during the development of the mouse female reproductive tract. Development. 1998;125:3201–3211
  3. Tulac S, Nayak NR, Kao LC, van Waes M, Huang J, Lobo S, et al. Identification, characterization, and regulation of the canonical Wnt signaling pathway in human endometrium. J Clin Endocrinol Metab. 2003;88:3860–3966
  4. Gaetje R, Holtrich U, Engels K, Kissler S, Rody A, Karn T, Kaufmann M. Endometriosis may be generated by mimicking the ontogenetic development of the female genital tract. Fertil Steril; Nov 28: [epub ahead of print].
  5. Hayashi K, Spencer TE. WNT pathways in the neonatal ovine uterus: potential specification of endometrial gland morphogenesis by SFRP2. Biol Reprod. 2006;74:721–733
  6. Miller C, Degenhardt K, Sassoon D. Fetal exposure to DES results in de-regulation of Wnt7a during uterine morphogenesis. Nat Genet. 1998;20:228–230
  7. Wagner J, Lehmann L. Estrogen modulate the gene expression of Wnt-7a in cultured endometrial adenocarcinoma cells. Mol Nutr Food Res. 2006;50:368–372
  8. Oehler MK, MacKenzie IZ, Wallwiener D, Bicknell R, Ress MC. Wnt-7a is upregulated by norethisterone in human endometrial epithelial cells: a possible mechanism by which progesterons reduce the risk of estrogen-induced endometrial neoplasia. Cancer Lett. 2002;186:75–81
  9. Tulac S, Overgaard MT, Hamilton AE, Jumbe NL, Suchanek E, Giudice LC. Dickkopf-1, an inhibitor of Wnt signaling, is reduced by progesterone in human endometrial stromal cells. J Clin Endocrinol Metab. 2006;91:1453–1461
  10. Holtrich U, Wolf G, Brauninger A, Karn T, Bohme B, Rubsamen-Waigmann H, et al. Induction and down-regulation of PLK, a human serine/threonine kinase expressed in proliferating cells and tumors. Proc Natl Acad Sci USA. 1994;91:1736–1740
  11. Ahr A, Holtrich U, Solbach C, Scharl A, Strebhardt K, Karn T, et al. Molecular classification of breast cancer patients by gene expression profiling. J Pathol. 2001;195:312–320
  12. Basyuk E, Bertrand E, Journot L. Alkaline fixation drastically improves the signal of in situ hybridization. Nucleic Acids Res. 2000;28:E46
  13. Revised American Society for Reproductive Medicine classification of endometriosis: 1996. Fertil Steril. 1997;67:817–821
  14. Bui TD, Zhang L, Ress MC, Bicknell R, Harris AL. Expression and hormone regulation of Wnt2, 3, 4, 5a, 7a, 7b and 10b in normal human endometrium and endometrial carcinoma. Br J Cancer. 1997;75:1131–1136
  15. Mericskay M, Kitajewski J, Sassoon D. WNT5A is required for proper epithelial-mesenchymal interactions in the uterus. Development. 2004;131:2061–2072

 Supported by grants from Deutsche Krebshilfe, Bonn Margarete Bonifer-Stiftung, Bad Soden, BANSS-Stiftung, Biedenkopf, and Dr. Robert Pfleger-Stiftung, Bamberg.

PII: S0015-0282(07)00276-2

doi: 10.1016/j.fertnstert.2007.01.128

Fertility and Sterility
Volume 88, Issue 6 , Pages 1534-1540 , December 2007

Article Tools

* Image Usage & Resolution