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Fertility and Sterility
Volume 90, Issue 3
, Pages 709-713
, September 2008
Successful pregnancies treated with pioglitazone in infertile patients with polycystic ovary syndrome
References
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- . Effects of metformin on ovulation rate, hormonal and metabolic profiles in women with clomiphene-resistant polycystic ovaries: a randomized, double-blinded placebo-controlled trial. Hum Reprod. 2001;8:1625–1631
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- . Peripheral androgen blockade versus glandular androgen suppression in the treatment of hirsutism. Obstet Gynecol. 1991;78:845–849
- . Use of damethasone and clomiphene citrate in the treatment of clomiphene citrate-resistant patients with polycystic ovary syndrome and normal dehydroepiandrosterone sulfate levels: a prospective, double-blind, placebo-controlled trial. Fertil Steril. 2002;78:1001–1004
- . Effect of the insulin sensitizer pioglitazone on insulin resistance, hyperandrogenism, and ovulatory dysfunction in women with polycystic ovary syndrome. J Clin Endocrinol Metab. 2004;89:3835–3840
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- Antiinflammatory and antiarteriosclerotic effects of pioglitazone. Hypertension. 2002;40:687–693
- . Diagnostic criteria for polycystic ovary syndrome: a rational approach. In: Dunaif A, Givens JR, Haselitime F, Merriam GR editor. Polycystic ovary syndrome. Cambridge, MA: Blackwell; 1992;p. 377–384
- . Pregnancy outcomes among women with polycystic ovary syndrome treated with metformin. Hum Reprod. 2002;17:2858–2864
- . Ovulation induction in clomiphene-resistant anovulatory women with normal DHEAS levels: beneficial effects the addition of dexamethasone during the follicular phase. Fertil Steril. 1996;66:484–486
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- . A systematic review of the reproductive system effects of metformin in patients with polycystic ovary syndrome. Fertil Steril. 2003;1:1–13
- . Effects of metformin and rosiglitazone, alone and in combination, in nonobese women with polycystic ovary syndrome and normal indices of insulin sensitivity. Fertil Steril. 2004;82:893–902
- Selective effects of pioglitazone on insulin and androgen abnormalities in normo- and hyperinsulinaemic obese patients with polycystic ovary syndrome. Hum Reprod. 2003;18:1210–1218
- . Enhanced granulosa cell responsiveness to follicle-stimulating hormone during insulin infusion in women with polycystic ovary syndrome treated with pioglitazone. J Clin Endocrinol Metab. 2003;88:5624–5631
- . Continuing metformin throughout pregnancy in women with polycystic ovary syndrome appears to safely reduce first-trimester spontaneous abortion: a pilot study. Fertil Steril. 2001;75:46–52
- . Thiazolidinediones but not metformin directly inhibit the steriodogenic enzymes P450c17 and 3β-hydroxysteroid dehydrogenase. J Biol Chem. 2001;276:16767–16771
- . Troglitazone, an insulin-sensitizing thiazolidinedione, represses combined stimulation by LH and insulin of de novo androgen biosynthesis by thecal cells in vitro. J Clin Endocrinol Metab. 2002;87:1129–1133
- . Troglitazone: a possible modulator of ovarian steroidogenesis. J Soc Gynecol Investig. 2002;9:163–167
- . Putative activation of the peroxisome proliferator-activated receptor γ impairs androgen and enhances progesterone biosynthesis in primary cultures of porcine theca cells. Biol Reprod. 2002;66:190–198
- . Metformin directly inhibits androgen production in human thecal cells. Fertil Steril. 2001;76:517–524
PII: S0015-0282(07)00282-8
doi: 10.1016/j.fertnstert.2007.01.117
© 2008 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
« Previous
Next »
Fertility and Sterility
Volume 90, Issue 3
, Pages 709-713
, September 2008

