Fertility and Sterility
Volume 89, Issue 2 , Pages 364-367 , February 2008

Pregnancy loss in the first in vitro fertilization cycle is not predictive of subsequent delivery in women over 40 years

  • Rita Sneeringer, M.D.

      Affiliations

    • Boston IVF, Waltham, Massachusetts
    • Beth Israel Deaconess Medical Center, Boston, Massachusetts
    • Harvard Medical School, Boston, Massachusetts
    • Corresponding Author InformationReprint requests: Rita Sneeringer, M.D., Beth Israel Deaconess Medical Center, 330 Brookline Avenue, KS-322, Boston, Massachusetts 02215 (FAX: 617-975-5575).
    • ,
  • Sigal Klipstein, M.D.

      Affiliations

    • Boston IVF, Waltham, Massachusetts
    • Beth Israel Deaconess Medical Center, Boston, Massachusetts
    • Harvard Medical School, Boston, Massachusetts
    • ,
  • David A. Ryley, M.D.

      Affiliations

    • Boston IVF, Waltham, Massachusetts
    • Beth Israel Deaconess Medical Center, Boston, Massachusetts
    • Harvard Medical School, Boston, Massachusetts
    • ,
  • Michael M. Alper, M.D.

      Affiliations

    • Boston IVF, Waltham, Massachusetts
    • Beth Israel Deaconess Medical Center, Boston, Massachusetts
    • Harvard Medical School, Boston, Massachusetts
    • ,
  • Richard H. Reindollar, M.D.

      Affiliations

    • Boston IVF, Waltham, Massachusetts
    • Beth Israel Deaconess Medical Center, Boston, Massachusetts
    • Harvard Medical School, Boston, Massachusetts

Received 18 September 2006 ,Revised 21 February 2007 ,Accepted 21 February 2007.

References 

  1. Tietze C. Reproductive span and rate of reproduction among Hutterite women. Fertil Steril. 1957;8:89–97
  2. Menken J, Trussel J, Larsen U. Age and infertility. Science. 1986;233:1389–1394
  3. Watt A, Legedza A, Ginsberg E, Barbieri R, Clarke R, Hornstein M. The prognostic value of age and FSH levels in women over forty years of age undergoing IVF. J Assist Reprod Genet. 2000;17:264–268
  4. Munne S, Cohen J, Sable D. Preimplantation genetic diagnosis for advanced maternal age and other indications. Fertil Steril. 2002;78:234–236
  5. Klipstein S, Regan M, Ryley D, Goldman M, Alper M, Reindollar R. How old is too old? A review of 2,705 cycles of ART in women aged forty and above at cycle start. Fertil Steril. 2005;84:435–445
  6. Smith K, Buyalos R. The profound impact of age on pregnancy outcome after early detection of fetal cardiac activity. Fertil Steril. 1996;65:35–40
  7. Bates G, Ginsberg E. Early pregnancy loss in IVF is a positive predictor of subsequent IVF success. Fertil Sterl. 2002;77:337–341
  8. Lass A, Croucher C, Duffy S, Dawson K, Margara R, Winston R. One thousand initiated cycles of IVF in women ≥40 years of age. Fertil Steril. 1998;70:1030–1034

 Conflicts of interest/financial support: none.

 Presented at the ASRM meeting 2004, Philadelphia, Pennsylvania.

 Present address of Sigal Klipstein: Karande and Associates, 1585 North Barrington Road, Suite 406, Hoffman Estates, Illinois 60194.

 Present address of Richard H. Reindollar: Dartmouth Hitchcock Medical Center, One Medical Center Drive, Lebanon, New Hampshire 03756.

PII: S0015-0282(07)00508-0

doi: 10.1016/j.fertnstert.2007.02.038

Fertility and Sterility
Volume 89, Issue 2 , Pages 364-367 , February 2008

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