Fertility and Sterility
Volume 89, Issue 2 , Pages 398-403 , February 2008

Estro-progestin supplementation enhances the growth hormone secretory responsiveness to ghrelin infusion in postmenopausal women

  • Paola Villa, M.D.

      Affiliations

    • Department of Obstetrics and Gynaecology, Catholic University of Sacred Heart, Rome, Italy
    • Corresponding Author InformationReprint requests: Paola Villa, M.D., Catholic University of Sacred Heart, Largo F. Vito 1, Rome, Italy (FAX: 39-063057794).
    • ,
  • Barbara Costantini, M.D.

      Affiliations

    • Department of Obstetrics and Gynaecology, Catholic University of Sacred Heart, Rome, Italy
    • ,
  • Concetta Perri, M.D.

      Affiliations

    • Department of Obstetrics and Gynaecology, Catholic University of Sacred Heart, Rome, Italy
    • ,
  • Rosanna Suriano, M.D.

      Affiliations

    • Department of Obstetrics and Gynaecology, Catholic University of Sacred Heart, Rome, Italy
    • ,
  • Luigi Ricciardi, M.D.

      Affiliations

    • Department of Obstetrics and Gynaecology, Catholic University of Sacred Heart, Rome, Italy
    • ,
  • Antonio Lanzone, M.D.

      Affiliations

    • Department of Obstetrics and Gynaecology, Catholic University of Sacred Heart, Rome, Italy
    • Unit of Physiopathology of Human Reproduction, OASI Institute for Research, Troina, Italy

Received 10 November 2006 ,Revised 19 February 2007 ,Accepted 21 February 2007.

References 

  1. Kato Y, Murakami Y, Sohmiya M, Nishiki M. Regulation of human growth hormone secretion and its disorder. Inter Med. 2002;41:7–13
  2. Smith RG, Van der Ploeg LHT, Howard AD, Feighner SD, Cheng K, Hickey GJ, et al. Peptidomimetic regulation of growth hormone secretion. Endocrinol Rev. 1997;18:621–645
  3. Bowers CY. Growth hormone-releasing peptides. In:  Kostyo JL,  Goodman HM editor. Handbook of physiology, sect 7. 5:New York, Oxford: Oxford University Press; 1999;p. 267–297
  4. Howard AD, Feighner SD, Cully DF, Arena JP, Liberator PA, Rosenblum CI, et al. A receptor in pituitary and hypothalamus that functions in growth hormone release. Science. 1996;273:974–977
  5. Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature. 1999;402:656–660
  6. Tannenbaum GS, Epelbaum J, Bowers CJ. Interrelationship between the novel peptide ghrelin and somatostatin /growth hormone-releasing hormone in regulation of pulsatile growth hormone secretion. Endocrinology. 2003;144:967–974
  7. Takaya K, Ariyasu H, Kanamoto N, Iwakura H, Yoshimoto A, Harada M, et al. Ghrelin strongly stimulates growth hormone (GH) release in humans. J Clin Endocrinol Metab. 2000;85:4908–4911
  8. Date Y, Murakami N, Kojima M, Kuroiwa T, Matsukura S, Kangawa K, et al. Central effects of a novel acylated peptide, ghrelin, on growth hormone release in rats. Biochem Biophys Res Commun. 2000;275:477–480
  9. Seoane LM, Tovar S, Baldelli R, Mallo F, Lopez M, Senaris R, et al. Ghrelin elicits a marked stimulatory effect on GH secretion in freely-moving rats. Eur J Endocrinol. 2000;143:R7–R9
  10. Arvat E, Di Vito L, Broglio F, Capotti M, Cuccioli G, Dieguez C, et al. Preliminary evidence that ghrelin, the natural GH secretagogue (GHS)-receptor ligand, strongly stimulates GH secretion in humans. J Endocrinol Invest. 2000;23:493–495
  11. Giustina D, Veldhuis JD. Pathophysiology of the neuroregulation of growth hormone secretion in experimental animals and the human. Endocrinol Rev. 1998;19:717–797
  12. Lanfranco F, Gianotti L, Giordano R, Pellegrino M, Maccario M, Arvat E. Ageing, growth hormone and physical performance. J Endocrinol Invest. 2003;26:861–872
  13. Broglio F, Benso A, Castiglioni C, Gottero C, Prodam F, Destefanis S, et al. The endocrine response to ghrelin as a function of gender in humans in young and elderly subjects. J Clin Endocrinol Metab. 2003;88:1537–1542
  14. Veldhuis JD, Keenan DM, Iranmanesh A, Mielke K, Miles JM, Bowers CY. Estradiol potentiates ghrelin-stimulated pulsatile growth hormone secretion in postmenopausal women. J Clin Endocrinol Metab. 2006;91:3559–3565
  15. Ciampelli M, Leoni F, Cucinelli F, Mancuso S, Panunzi S, De Gaetano A, et al. Assessment of insulin sensitivity from measurements in the fasting state and during an oral glucose tolerance test in polycystic ovary syndrome and menopausal patients. J Clin Endocrinol Metab. 2005;90:1398–1406
  16. Petersenn S. Growth hormone secretagogues and ghrelin: an update on physiology and clinical relevance. Horm Res. 2002;58(Suppl 3):56–61
  17. Bowers CY. Unnatural growth hormone-releasing peptide begets natural ghrelin. J Clin Endocrinol Metab. 2001;86:1464–1469
  18. Wren AM, Small CJ, Ward HL, Murphy KG, Dakin CL, Taheri S, et al. The novel hypothalamic peptide ghrelin stimulates food intake and growth hormone secretion. Endocrinology. 2000;141:4325–4328
  19. Tschop M, Smiley DL, Behman ML. Ghrelin induces adiposity in rodents. Nature. 2000;47:908–913
  20. Friend KE, Hartman ML, Pezzoli SS, Clasey JL, Thorner MO. Both oral and transdermal estrogen increase growth hormone release in post-menopausal—A clinical research study. J Clin Endocrinol Metab. 1996;81:2250–2256
  21. Veldhuis JD, Anderson SM, Patrie JT, Bowers CY. Estradiol supplementation in postmenopausal women doubles rebound-like release of growth hormone (GH) triggered by sequential infusion and withdrawal of somatostatin: evidence that estrogen facilitates endogenous GH-releasing hormone drive. J Clin Endocrinol Metab. 2004;89:121–127
  22. Veldhuis JD, Anderson SM, Kok P, Iranmanesh A, Frystyk J, Orskov H, et al. Estradiol supplementation modulates growth hormone (GH) secretory-burst waveform and recombinant human insulin-like growth factor-I-enforced suppression of endogenously driven GH release in postmenopausal women. J Clin Endocrinol Metab. 2004;89:1312–1318
  23. Anderson SM, Shah N, Evans WS, Patrie JT, Bowers CY, Veldhuis JD. Short-term estradiol supplementation augments growth hormone (GH) secretory responsiveness to dose-varying GH-releasing peptide infusion in healthy post-menopausal women. J Clin Endocrinol Metab. 2001;86:551–560
  24. Bellantoni MF, Harman SM, Cho DE, Blackman MR. Effects of progestin-opposed transdermal estrogen administration on growth hormone and insulin-like growth factor-I in postmenopausal women of different ages. J Clin Endocrinol Metab. 1991;72:172–178
  25. Campagnoli C, Ambroggio S, Peris C. Differential effects of progestins on the circulating IGF-I system. Maturitas. 2003;46S1:S39–S44
  26. Kaji H, Tai S, Okimura Y, Okimur Y, Iguchi G, Takahashi Y, et al. Cloning and characterization of the 5'-flanking region of the human growth hormone secretagogue receptor gene. J Biol Chem. 1998;273:33885–33888
  27. Bray MJ, Vick TM, Shah N, Anderson SM, Rice LW, Iranmanesh A, et al. Short-term estradiol replacement in post-menopausal women selectively mutes somatostatin's dose-dependent inhibition of fasting growth hormone secretion. J Clin Endocrinol Metab. 2001;86:3143–3149
  28. Di Vito L, Broglio F, Benso A, Gottero C, Prodam F, Papotti M, et al. The GH releasing effect of ghrelin, a natural GH secretagogue, is only blunted by the infusion of exogenous somatostatin in humans. Clin Endocrinol (Oxf). 2002;56:643–648
  29. Bethea CL. Estrogen action on growth hormone in pituitary cell cultures from adult and juvenile macaques. Endocrinology. 1991;129:2110–2118
  30. Simard J, Hubert JF, Hosseinzadeh T, Labrie F. Stimulation of growth hormone release and synthesis by estrogens in rat anterior pituitary cells in culture. Endocrinology. 1986;119:2004–2011
  31. Balogh A, Kauf E, Vollanth R, Graser G, Klinger G, Oettel M. Effects of two oral contraceptives on plasma levels of insulin-like growth factor-I (IGF-I) and growth hormone (hGH). Contraception. 2000;62:259–269
  32. Rozembaum H. Pharmacology of progesterone and related compounds: dydrogesterone and norpregnane derivatives. Menopause Rev. 2001;VI:17–28
  33. Lieman HJ, Adel TE, Forst C, von Haghen S, Santoro N. Effects of aging and estradiol supplementation on GH axis dynamics in women. J Clin Endocrinol Metab. 2001;86:3918–3923
  34. Genazzani AD, Gamba O, Nappi L, Volpe A, Petraglia F. Modulatory effects of synthetic steroid (titolone) and estradiol on spontaneous and GH-RH-induced GH secretion in post-menopausal women. Maturitas. 1997;28:27–33
  35. Shah N, Evans WS, Veldhuis JD. Actions of estrogen on pulsatile, nyctohemeral and entropic modes of growth hormone secretion. Am J Physiol Regulatory Integrative Comp Physiol. 1999;276:1351–1358
  36. Cano A, Castelo-Branco C, Tarin JJ. Effect of menopause and different combined estradiol-progestin regimens on basal and growth hormone-releasing hormone-stimulated serum growth hormone, insulin-like growth factor-1, insulin-like growth factor binding protein (IGFBP)-1, and IGFBP-3 levels. Fertil Steril. 1999;71:261–267
  37. Williams T, Berelowitz M, Joffe S, Thorner MO, Rivier J, Vale W, et al. Impaired growth hormone responses to growth hormone-releasing factor in obesity. A pituitary defect reversed by weight reduction. N Engl J Med. 1984;311:1403–1407
  38. Jung R. Endocrinological aspects of obesity. In:  James WPT editors. Clinics in endocrinology and metabolism. Vol 13:Philadelphia: WB Saunders; 1984;p. 597–612
  39. Lebenthal Y, Gat-Yablonski G, Shtaif B, Padoa A, Phillip M, Lazar L. Effect of sex hormone administration on circulating ghrelin levels in peripubertal children. J Clin Endocrinol Metab. 2006;91:328–331
  40. Giustina A, Scalvini T, Tassi C, Desenzani P, Poiesi C, Wehrenberg WB, et al. Maturation of the regulation of growth hormone secretion in young males with hypogonadotropic hypogonadism pharmacologically exposed to progressive increments in serum testosterone. J Clin Endocrinol Metab. 1997;82:1210–1219

PII: S0015-0282(07)00512-2

doi: 10.1016/j.fertnstert.2007.02.042

Fertility and Sterility
Volume 89, Issue 2 , Pages 398-403 , February 2008

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