Fertility and Sterility
Volume 89, Issue 2 , Pages 375-379 , February 2008

Effect of vaginal lubricants on sperm motility and chromatin integrity: a prospective comparative study

  • Ashok Agarwal, Ph.D.

      Affiliations

    • Reproductive Research Center, Glickman Urological Institute and Department of Obstetrics-Gynecology, Cleveland Clinic, Cleveland, Ohio
    • Corresponding Author InformationReprint requests: Ashok Agarwal, Ph.D., Professor, Lerner College of Medicine of Case Western Reserve University, Director, Reproductive Research Center, Glickman Urological Institute and Department of Obstetrics-Gynecology, The Cleveland Clinic Foundation, 9500 Euclid Ave., Desk A19.1, Cleveland, OH 44195 (FAX: 216-445-6049).
    • ,
  • Fnu Deepinder, M.D.

      Affiliations

    • Reproductive Research Center, Glickman Urological Institute and Department of Obstetrics-Gynecology, Cleveland Clinic, Cleveland, Ohio
    • ,
  • Marcello Cocuzza, M.D.

      Affiliations

    • Reproductive Research Center, Glickman Urological Institute and Department of Obstetrics-Gynecology, Cleveland Clinic, Cleveland, Ohio
    • ,
  • Robert A. Short, Ph.D.

      Affiliations

    • Washington State University, Spokane, Washington
    • ,
  • Donald P. Evenson, Ph.D.

      Affiliations

    • South Dakota State University, Brookings, South Dakota

Received 14 December 2006 ,Revised 21 February 2007 ,Accepted 22 February 2007.

References 

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  12. World Health Organization . Laboratory manual for the examination of human semen and semen–cervical mucus interaction. 4th ed.. New York: Cambridge University Press; 1999;56–61
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  14. Ellington JE, Evenson DP, Fleming JE, Brisbois RS, Hiss GA, Broder SJ, et al. Coculture of human sperm with bovine oviduct epithelial cells decreases sperm chromatin structural changes seen during culture in media alone. Fertil Steril. 1998;69:643–649
  15. Estop AM, Munne S, Jost LK, Evenson DP. Studies on sperm chromatin structure alterations and cytogenetic damage of mouse sperm following in vitro incubation. Studies on in vitro-incubated mouse sperm. J Androl. 1993;14:282–288
  16. Munne S, Estop A. The effect of in-vitro ageing on mouse sperm chromosomes. Hum Reprod. 1991;6:703–708
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  18. Ellington JE, Short RA. Prevalence of vaginal dryness in trying to conceive couples. Pacific Coast Reproductive Society Meeting, April 23–27, 2003; Rancho Mirage, California.
  19. Guttmacher AF, Shettles LB. Cyclic changes in cervical mucus, and its practical importance. Hum Fertil. 1940;5:4–9
  20. Rossato M, Balercia G, Lucarelli G, Foresta C, Mantero F. Role of seminal osmolarity in the reduction of human sperm motility. Int J Androl. 2002;25:230–235
  21. Makler A, David R, Blumenfeld Z, Better OS. Factors affecting sperm motility. VII. Sperm viability as affected by change of pH and osmolarity of semen and urine specimens. Fertil Steril. 1981;36:507–511
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  24. Ellington JE, Schimmels J. The effects of vaginal lubricants and moisturizers on computer assisted sperm analysis (CASA) parameters associated with cervical mucus penetration. Fertil Steril. 2004;82:S145–S146

 Presented at the 61st Annual Meeting of the American Society for Reproductive Medicine, Montreal, Quebec, Canada, October 18, 2005.

PII: S0015-0282(07)00518-3

doi: 10.1016/j.fertnstert.2007.02.050

Fertility and Sterility
Volume 89, Issue 2 , Pages 375-379 , February 2008

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