Fertility and Sterility
Volume 89, Issue 6 , Pages 1760-1765 , June 2008

Increased intrafollicular androgen levels affect human granulosa cell secretion of anti-müllerian hormone and inhibin-B

  • Claus Yding Andersen, D.M.Sc.

      Affiliations

    • Laboratory of Reproductive Biology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    • Corresponding Author InformationReprint requests: Claus Yding Andersen, D.M.Sc., Laboratory of Reproductive Biology, Section 5712, University Hospital of Copenhagen, Blegdamsvej 9, Rigshospitalet, DK-2100 Copenhagen, Denmark (FAX: 45-35455824).
    • ,
  • Kristine Lossl, M.D.

      Affiliations

    • Laboratory of Reproductive Biology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    • The Fertility Clinic, The Juliane Marie Centre for Women, Children and Reproduction, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark

Received 22 January 2007 ,Revised 1 May 2007 ,Accepted 1 May 2007.

References 

  1. Mouridsen HT, Rose C, Brodie AH, Smith IE. Challenges in the endocrine management of breast cancer. Breast. 2003;12(suppl 2):S2–S19
  2. Mouridsen HT. Incidence and management of side effects associated with aromatase inhibitors in the adjuvant treatment of breast cancer in postmenopausal women. Curr Med Res Opin. 2006;22:1609–1621
  3. Miller WR, Anderson TJ, White S, Larionov A, Murray J, Evans D, et al. Aromatase inhibitors: cellular and molecular effects. J Steroid Biochem Mol Biol. 2005;95:83–89
  4. Casper RF, Mitwally MF. Aromatase inhibitors for ovulation induction. J Clin Endocrinol Metab. 2006;91:760–771
  5. Lossl K, Andersen AN, Loft A, Freiesleben NL, Bangsboll S, Yding Andersen C. Androgen priming using aromatase inhibitor and hCG during early-follicular-phase GnRH antagonist down-regulation in modified antagonist protocols. Hum Reprod. 2006;21:2593–2600
  6. Tetsuka M, Hillier SG. Differential regulation of aromatase and androgen receptor in granulosa cells. J Steroid Biochem Mol Biol. 1997;61:233–239
  7. Weil SJ, Vendola K, Zhou J, Bondy CA. Androgen and follicle-stimulating hormone interactions in primate ovarian follicle development. J Clin Endocrinol Metab. 1999;84:2951–2956
  8. Visser JA, de Jong FH, Laven JS, Themmen AP. Anti-Müllerian hormone: a new marker for ovarian function. Reproduction. 2006;131:1–9
  9. Yding Andersen C, Byskov AG. Estradiol and regulation of anti-Mullerian hormone, inhibin-A, and inhibin-B secretion: analysis of small antral and preovulatory human follicles' fluid. J Clin Endocrinol Metab. 2006;91:4064–4069
  10. Pellatt L, Hanna L, Brincat M, Galea R, Brain H, Whitehead S, et al. Granulosa cell production of anti-Müllerian hormone is increased in polycystic ovaries. J Clin Endocrinol Metab. 2007;92:240–245
  11. Lambert-Messerlian G, Taylor A, Leykin L, Isaacson K, Toth T, Chang Y, et al. Characterization of intrafollicular steroid hormones, inhibin, and follistatin in women with and without polycystic ovarian syndrome following gonadotropin hyperstimulation. Biol Reprod. 1997;57:1211–1216
  12. Welt CK, Taylor AE, Fox J, Messerlian GM, Adams JM, Schneyer AL. 2005 Follicular arrest in polycystic ovary syndrome is associated with deficient inhibin A and B biosynthesis. J Clin Endocrinol Metab. 2006;90:5582–5587
  13. Wachs DS, Coffler MS, Malcom PJ, Chang RJ. Comparison of follicle-stimulating-hormone-stimulated dimeric inhibin and estradiol responses as indicators of granulosa cell function in polycystic ovary syndrome and normal women. J Clin Endocrinol Metab. 2006;91:2920–2925
  14. McNatty KP, Smith DM, Makris A, Osathanondh R, Ryan KJ. The microenvironment of the human antral follicle: interrelationships among the steroid levels in antral fluid, the population of granulosa cells, and the status of the oocyte in vivo and in vitro. J Clin Endocrinol Metab. 1979;49:851–860
  15. Yding Andersen C. Characteristics of human follicular fluid associated with successful conception after in vitro fertilization. J Clin Endocrinol Metab. 1993;77:1227–1234

PII: S0015-0282(07)01030-8

doi: 10.1016/j.fertnstert.2007.05.003

Fertility and Sterility
Volume 89, Issue 6 , Pages 1760-1765 , June 2008

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