Fertility and Sterility
Volume 89, Issue 5 , Pages 1191-1199 , May 2008

The significance of sperm DNA oxidation in embryo development and reproductive outcome in an oocyte donation program: a new model to study a male infertility prognostic factor

  • Marcos Meseguer, Ph.D.

      Affiliations

    • Instituto Valenciano de Infertilidad Valencia, Universidad de Valencia, Valencia, Spain
    • Fundación IVI, Valencia, Spain
    • Corresponding Author InformationReprint requests: Dr. Marcos Meseguer, Instituto Valenciano de Infertilidad, Plaza de la Policía Local, 3, Valencia 46015, Spain (FAX: 3496-3050999).
    • ,
  • J.A. Martínez-Conejero, Ph.D.

      Affiliations

    • Instituto Valenciano de Infertilidad Valencia, Universidad de Valencia, Valencia, Spain
    • Fundación IVI, Valencia, Spain
    • ,
  • J. Enrique O'Connor, Ph.D.

      Affiliations

    • Unidad de Citómica, Centro de Investigación Príncipe Felipe, Valencia, Spain
    • ,
  • Antonio Pellicer, M.D.

      Affiliations

    • Instituto Valenciano de Infertilidad Valencia, Universidad de Valencia, Valencia, Spain
    • Fundación IVI, Valencia, Spain
    • ,
  • José Remohí, M.D.

      Affiliations

    • Instituto Valenciano de Infertilidad Valencia, Universidad de Valencia, Valencia, Spain
    • Fundación IVI, Valencia, Spain
    • ,
  • Nicolás Garrido, Ph.D.

      Affiliations

    • Instituto Valenciano de Infertilidad Valencia, Universidad de Valencia, Valencia, Spain
    • Fundación IVI, Valencia, Spain

Received 12 February 2007 ,Revised 1 May 2007 ,Accepted 1 May 2007.

References 

  1. Guerin P, El Mouatassim S, Menezo Y. Oxidative stress and protection against reactive oxygen species in the pre-implantation embryo and its surroundings. Hum Reprod Update. 2001;7:175–189
  2. Oger I, Da Cruz C, Panteix G, Menezo Y. Evaluating human sperm DNA integrity: relationship between 8-hydroxydeoxyguanosine quantification and the sperm chromatin structure assay. Zygote. 2003;11:367–371
  3. Muriel L, Meseguer M, Fernandez JL, Alvarez J, Remohi J, Pellicer A, et al. Value of the sperm chromatin dispersion test in predicting pregnancy outcome in intrauterine insemination: a blind prospective study. Hum Reprod. 2006;21:738–744
  4. Muriel L, Garrido N, Fernandez JL, Remohi J, Pellicer A, de los Santos MJ, et al. Value of the sperm deoxyribonucleic acid fragmentation level, as measured by the sperm chromatin dispersion test, in the outcome of in vitro fertilization and intracytoplasmic sperm injection. Fertil Steril. 2006;85:371–383
  5. Garrido N, Meseguer M, Alvarez J, Simon C, Pellicer A, Remohi J. Relationship among standard semen parameters, glutathione peroxidase/glutathione reductase activity, and mRNA expression and reduced glutathione content in ejaculated spermatozoa from fertile and infertile men. Fertil Steril. 2004;82(Suppl 3):1059–1066
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  7. Meseguer M, de los Santos MJ, Simon C, Pellicer A, Remohi J, Garrido N. Effect of sperm glutathione peroxidases 1 and 4 on embryo asymmetry and blastocyst quality in oocyte donation cycles. Fertil Steril. 2006;86:1376–1385
  8. Menezo YJ, Veiga A, Pouly JL. Assisted reproductive technology (ART) in humans: facts and uncertainties. Theriogenology. 2000;53:599–610
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  10. Meseguer M, Garrido N, Martinez-Conejero JA, Simon C, Pellicer A, Remohi J. Role of cholesterol, calcium, and mitochondrial activity in the susceptibility for cryodamage after a cycle of freezing and thawing. Fertil Steril. 2004;81:588–594
  11. Meseguer M, Molina N, Garcia-Velasco JA, Remohi J, Pellicer A, Garrido N. Sperm cryopreservation in oncological patients: a 14-year follow-up study. Fertil Steril. 2006;85:640–645
  12. Meseguer M, Garrido N, Simon C, Pellicer A, Remohi J. Concentration of glutathione and expression of glutathione peroxidases 1 and 4 in fresh sperm provide a forecast of the outcome of cryopreservation of human spermatozoa. J Androl. 2004;25:773–780
  13. Garrido N, Meseguer M, Remohi J, Pellicer A, Simon C. Flow cytometry in human reproductive biology. Gynecol Endocrinol. 2002;16:505–521
  14. de Zwart LL, Meerman JH, Commandeur JN, Vermeulen NP. Biomarkers of free radical damage applications in experimental animals and in humans. Free Radic Biol Med. 1999;26:202–226
  15. Garrido N, Meseguer M, Bellver J, Remohi J, Simon C, Pellicer A. Report of the results of a 2 year programme of sperm wash and ICSI treatment for human immunodeficiency virus and hepatitis C virus serodiscordant couples. Hum Reprod. 2004;19:2581–2586
  16. Garrido N, Zuzuarregui JL, Meseguer M, Simon C, Remohi J, Pellicer A. Sperm and oocyte donor selection and management: experience of a 10 year follow-up of more than 2100 candidates. Hum Reprod. 2002;17:3142–3148
  17. Meseguer M, Garrido N, Remohi J, Pellicer A, Simon C, Martinez-Jabaloyas JM, et al. Testicular sperm extraction (TESE) and ICSI in patients with permanent azoospermia after chemotherapy. Hum Reprod. 2003;18:1281–1285
  18. de los Santos MJ, Mercader A, Galan A, Albert C, Romero JL, Pellicer A. Implantation rates after two, three, or five days of embryo culture. Placenta. 2003;24(Suppl B):S13–S19
  19. Gamiz P, Rubio C, de los Santos MJ, Mercader A, Simon C, Remohi J, et al. The effect of pronuclear morphology on early development and chromosomal abnormalities in cleavage-stage embryos. Hum Reprod. 2003;18:2413–2419
  20. Meseguer M, Garrido N, Martinez-Conejero JA, Simon C, Pellicer A, Remohi J. Relationship between standard semen parameters, calcium, cholesterol contents, and mitochondrial activity in ejaculated spermatozoa from fertile and infertile males. J Assist Reprod Genet. 2004;21:445–451
  21. Fraga CG, Motchnik PA, Wyrobek AJ, Rempel DM, Ames BN. Smoking and low antioxidant levels increase oxidative damage to sperm DNA. Mutat Res. 1996;351:199–203
  22. Ni ZY, Liu YQ, Shen HM, Chia SE, Ong CN. Does the increase of 8-hydroxydeoxyguanosine lead to poor sperm quality?. Mutat Res. 1997;381:77–82
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  24. Agarwal A, Saleh RA, Bedaiwy MA. Role of reactive oxygen species in the pathophysiology of human reproduction. Fertil Steril. 2003;79:829–843
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 Supported by CDTI 20070038, Spain Goberment.

PII: S0015-0282(07)01033-3

doi: 10.1016/j.fertnstert.2007.05.005

Fertility and Sterility
Volume 89, Issue 5 , Pages 1191-1199 , May 2008

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