Fertility and Sterility
Volume 90, Issue 1 , Pages 17-22 , July 2008

Use of the levonorgestrel-releasing intrauterine system in breast cancer patients

  • Xuan Bich Trinh, M.D.

      Affiliations

    • Department of Obstetrics and Gynaecology, General Hospital St. Augustinus, Wilrijk, Belgium
    • Department of Gynaecologic Oncology, University Hospital Antwerp, Edegem, Belgium
    • Corresponding Author InformationReprint requests: Xuan Bich Trinh, M.D., Department of Obstetrics and Gynaecology, St. Augustinus General Hospital, Oosterveldlaan 24, 2610 Wilrijk, Belgium (FAX: 32-3-443-30-36).
    • ,
  • Wiebren A.A. Tjalma, M.D., Ph.D.

      Affiliations

    • Department of Gynaecologic Oncology, University Hospital Antwerp, Edegem, Belgium
    • ,
  • Amin P. Makar, M.D., Ph.D.

      Affiliations

    • Department of Gynaecologic Oncology, The Middelheim Hospital, Antwerp, Belgium
    • Department of Gynaecologic Oncology, University Hospital Ghent, Ghent, Belgium
    • ,
  • Guy Buytaert, M.D.

      Affiliations

    • Department of Obstetrics and Gynaecology, Klina Hospital, Brasschaat, Belgium
    • ,
  • Joost Weyler, M.D., Ph.D.

      Affiliations

    • Department of Epidemiology and Social Medicine, University of Antwerp, Wilrijk, Belgium
    • ,
  • Peter A. van Dam, M.D., Ph.D.

      Affiliations

    • Department of Obstetrics and Gynaecology, General Hospital St. Augustinus, Wilrijk, Belgium

Received 30 December 2006 ,Revised 29 May 2007 ,Accepted 29 May 2007.

References 

  1. Gardner FJ, Konje JC, Abrams KR, Brown LJ, Khanna S, Al Azzawi F, et al. Endometrial protection from tamoxifen-stimulated changes by a levonorgestrel-releasing intrauterine system: a randomised controlled trial. Lancet. 2000;356:1711–1717
  2. Trinh XB, Peeters F, Tjalma WA. The thoughts of breast cancer survivors regarding the need for starting hormone replacement therapy. Eur J Obstet Gynecol Reprod Biol. 2006;124:250–253
  3. Trinh XB, Van Hal G, Weyler J, Tjalma WA. The thoughts of physicians regarding the need to start hormone replacement therapy in breast cancer survivors. Eur J Obstet Gynecol Reprod Biol. 2006;124:207–211
  4. Backman T, Rauramo I, Jaakkola K, Inki P, Vaahtera K, Launonen A, et al. Use of the levonorgestrel-releasing intrauterine system and breast cancer. Obstet Gynecol. 2005;106:813–817
  5. Jordan A. Toxicology of progestogens of implantable contraceptives for women. Contraception. 2002;65:3–8
  6. Tjalma WA, Trinh XB, van Dam PA. Use of the levonorgestrel-releasing intrauterine system and breast cancer. Obstet Gynecol. 2006;107:207–208
  7. Mirkin S, Wong BC, Archer DF. Effect of 17 beta-estradiol, progesterone, synthetic progestins, tibolone, and tibolone metabolites on vascular endothelial growth factor mRNA in breast cancer cells. Fertil Steril. 2005;84:485–491
  8. Schoonen WG, Joosten JW, Kloosterboer HJ. Effects of two classes of progestagens, pregnane and 19-nortestosterone derivatives, on cell growth of human breast tumor cells: II. T47D cell lines. J Steroid Biochem Mol Biol. 1995;55:439–444
  9. Schoonen WG, Joosten JW, Kloosterboer HJ. Effects of two classes of progestagens, pregnane and 19-nortestosterone derivatives, on cell growth of human breast tumor cells: I. MCF-7 cell lines. J Steroid Biochem Mol Biol. 1995;55:423–437
  10. van der BB, Kalkhoven E, Isbrucker L, de Laat SW. Effects of progestins on the proliferation of estrogen-dependent human breast cancer cells under growth factor-defined conditions. J Steroid Biochem Mol Biol. 1992;42:457–465
  11. Trinh XB, van Dam PA, Tjalma WA. Plasma concentrations of levonorgestrel in patients with an intrauterine progestogen delivery system: do they have any significance?. Maturitas. 2006;55:94–95
  12. Lockhat FB, Emembolu JE, Konje JC. Serum and peritoneal fluid levels of levonorgestrel in women with endometriosis who were treated with an intrauterine contraceptive device containing levonorgestrel. Fertil Steril. 2005;83:398–404
  13. Xiao BL, Zhou LY, Zhang XL, Jia MC, Luukkainen T, Allonen H. Pharmacokinetic and pharmacodynamic studies of levonorgestrel-releasing intrauterine device. Contraception. 1990;41:353–362
  14. Nilsson CG, Lahteenmaki P, Luukkainen T. Levonorgestrel plasma concentrations and hormone profiles after insertion and after one year of treatment with a levonorgestrel-IUD. Contraception. 1980;21:225–233
  15. Raudaskoski T, Tapanainen J, Tomas E, Luotola H, Pekonen F, Ronni-Sivula H, et al. Intrauterine 10 microg and 20 microg levonorgestrel systems in postmenopausal women receiving oral oestrogen replacement therapy: clinical, endometrial and metabolic response. BJOG. 2002;109:136–144
  16. Haimov-Kochman R, Amsalem H, Adoni A, Lavy Y, Spitz IM. Management of a perforated levonorgestrel-medicated intrauterine device—a pharmacokinetic study: case report. Hum Reprod. 2003;18:1231–1233
  17. Pakarinen P, Lahteenmaki P, Rutanen EM. The effect of intrauterine and oral levonorgestrel administration on serum concentrations of sex hormone-binding globulin, insulin and insulin-like growth factor binding protein-1. Acta Obstet Gynecol Scand. 1999;78:423–428
  18. Nassr N, Farker K, Lautenschlager M, Nagel U, Zimmermann H, Mellinger U, et al. Bioavailability study with 2 different levonorgestrel-containing drugs in women. Int J Clin Pharmacol Ther. 1997;35:123–127
  19. Chlebowski RT, Hendrix SL, Langer RD, Stefanick ML, Gass M, Lane D, et al. Influence of estrogen plus progestin on breast cancer and mammography in healthy postmenopausal women: the Women's Health Initiative randomized trial. JAMA. 2003;289:3243–3253
  20. Masamura S, Santner SJ, Heitjan DF, Santen RJ. Estrogen deprivation causes estradiol hypersensitivity in human breast cancer cells. J Clin Endocrinol Metab. 1995;80:2918–2925
  21. Boutet G. [Levonorgestrel-releasing intrauterine device (Mirena(R)) and breast cancer: what do we learn from literature for clinical practice?]. Gynecol Obstet Fertil. 2006;34:1015–1023

 P.A.v.D. participated in a phase III trial for Schering and has been an invited speaker for Schering, Organon, Astra Zeneca, and Novartis.

PII: S0015-0282(07)01200-9

doi: 10.1016/j.fertnstert.2007.05.033

Fertility and Sterility
Volume 90, Issue 1 , Pages 17-22 , July 2008

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