Fertility and Sterility
Volume 90, Issue 1 , Pages 92-96 , July 2008

Assisted reproductive technology may increase clinical mutation detection in male offspring

  • Chun Feng, M.D.

      Affiliations

    • Department of Reproductive Endocrinology, Women's Hospital, School of Medicine, Zhejiang University, Zhejiang, China
    • ,
  • Li-Quan Wang, M.D., Ph.D.

      Affiliations

    • Department of Reproductive Endocrinology, Women's Hospital, School of Medicine, Zhejiang University, Zhejiang, China
    • ,
  • Min-Yue Dong, M.D., Ph.D.

      Affiliations

    • Department of Reproductive Endocrinology, Women's Hospital, School of Medicine, Zhejiang University, Zhejiang, China
    • Key Laboratory of Women's Reproductive Health, Hangzhou, Zhejiang, China
    • ,
  • He-Feng Huang, M.D.

      Affiliations

    • Department of Reproductive Endocrinology, Women's Hospital, School of Medicine, Zhejiang University, Zhejiang, China
    • Key Laboratory of Women's Reproductive Health, Hangzhou, Zhejiang, China
    • Corresponding Author InformationReprint requests: He-Feng Huang, M.D., Department of Reproductive Endocrinology, Women's Hospital, School of Medicine, Zhejiang University, 2 Xueshi Road, Hangzhou, Zhejiang 310006, China (FAX: 86-571-87061878).

Received 8 March 2007 ,Revised 4 June 2007 ,Accepted 4 June 2007.

References 

  1. Jackson RA, Gibson KA, Wu YW, Croughan MS. Perinatal outcomes in singletons following in vitro fertilization: a meta-analysis. Obstet Gynecol. 2004;103:551–563
  2. Helmerhorst FM, Perquin DA, Donker D, Keirse MJ. Perinatal outcome of singletons and twins after assisted conception: a systematic review of controlled studies. BMJ. 2004;328:261–265
  3. Stromberg B, Dahlquist G, Ericson A, Finnstrom O, Koster M, Stjernqvis K. Neurological sequelae in children born after in-vitro fertilisation: a population-based study. Lancet. 2002;359:461–465
  4. Hansen M, Bower C, Milne E, De Klerk N, Kurinczuk JJ. Assisted reproductive technologies and the risk of birth defects—a systematic review. Hum Reprod. 2005;20:328–338
  5. Bonduelle M, Camus M, De Vos A, Staessen C, Tournaye H, Van Assche E, et al. Seven years of intracytoplasmic sperm injection and follow-up of 1987 subsequent children. Hum Reprod. 1999;14:243–264
  6. Bonduelle M, Liebaers I, Deketelaere V, Derde MP, Camus M, Devroey P, et al. Neonatal data on a cohort of 2889 infants born after ICSI (1991-1999) and of 2995 infants born after IVF (1983-1999). Hum Reprod. 2002;17:671–694
  7. Martin RH. The risk of chromosomal abnormalities following ICSI. Hum Reprod. 1996;11:924–925
  8. Tiepolo L, Zuffardi O. Localization of factors controlling spermatogenesis in the nonfluorescent portion of the human Y chromosome long arm. Hum Genet. 1976;34:119–124
  9. Kent-First M, Muallem A, Shultz J, Pryor J, Roberts K, Nolten W, et al. Defining regions of the Y-chromosome responsible for male infertility and identification of a fourth AZF region (AZFd) by Y-chromosome microdeletion detection. Mol Reprod Dev. 1999;53:27–41
  10. Kent-First MG, Kol S, Muallem A, Ofir R, Manor D, Blazer S, et al. The incidence and possible relevance of Y-linked microdeletions in babies born after intracytoplasmic sperm injection and their infertile fathers. Mol Hum Reprod. 1996;2:943–950
  11. Page DC, Silber S, Brown LG. Men with infertility caused by AZFc deletion can produce sons by ICSI, but are likely to transmit the deletion and infertility. Hum Reprod. 1999;14:1722–1726
  12. Cram DS, Ma K, Bhasin S, Arias J, Pandjaitan M, Chu B, et al. Y chromosome analysis of infertile men and their sons conceived through intracytoplasmic sperm injection: vertical transmission of deletions and rarity of de novo deletions. Fertil Steril. 2000;74:909–915
  13. Komori S, Kato H, Kobayashi S, Koyama K, Isojima S. Transmission of Y chromosomal microdeletions from father to son through intracytoplasmic sperm injection. J Hum Genet. 2002;47:465–468
  14. Oates RD, Silber S, Brown LG, Page DC. Clinical characterization of 42 oligospermic or azoospermic men with microdeletion of the AZFc region of the Y chromosome, and of 18 children conceived via ICSI. Hum Reprod. 2002;17:2813–2824
  15. Buch B, Galan JJ, Lara M, Real LM, Martinez-Moya M, Ruiz A. Absence of de novo Y-chromosome microdeletions in male children conceived through intracytoplasmic sperm injection. Fertil Steril. 2004;82:1679–1680
  16. Lee SH, Ahn SY, Lee KW, Kwack K, Jun HS, Cha KY. Intracytoplasmic sperm injection may lead to vertical transmission, expansion, and de novo occurrence of Y-chromosome microdeletions in male fetuses. Fertil Steril. 2006;85:1512–1515
  17. Vollrath D, Foote S, Hilton A, Brown LG, Beer-Romero P, Bogan JS, et al. The human Y chromosome: a 43-interval map based on naturally occurring deletions. Science. 1992;258:52–59
  18. Ma K, Inglis JD, Sharkey A, Bickmore WA, Hill RE, Prosser EJ, et al. A Y chromosome gene family with RNA-binding protein homology: candidates for the azoospermia factor AZF controlling human spermatogenesis. Cell. 1993;75:1287–1295
  19. Vereb M, Agulnik AI, Houston JT, Lipschultz LI, Lamb DJ, Bishop CE. Absence of DAZ gene mutations in cases of non-obstructed azoospermia. Mol Hum Reprod. 1997;3:55–59
  20. Shimizu A, Ichikawa T, Suzuki N, Yamazaki T, Imamoto T, Kojima S, et al. Microdeletions in the Y chromosome of patients with idiopathic azoospermia. Asian J Androl. 2002;4:111–115
  21. Muslumanoglu MH, Turgut M, Cilingir O, Can C, Ozyurek Y, Artan S. Role of the AZFd locus in spermatogenesis. Fertil Steril. 2005;84:519–522
  22. Wang LQ, Huang HF, Jin F, Qian YL, Cheng Q. High frequency of Y chromosome microdeletions in idiopathic azoospermic men with high follicle-stimulating hormone levels. Fertil Steril. 2005;83:1050–1052
  23. Kallen B, Finnstrom O, Nygren KG, Olausson PO. In vitro fertilization (IVF) in Sweden: risk for congenital malformations after different IVF methods. Birth Defects Res A Clin Mol Teratol. 2005;73:162–169
  24. Serebrovska ZA, Serebrovskaya TV, Pyle RL, Di Pietro ML. Transmission of male infertility and intracytoplasmic sperm injection (mini-review). Fiziol Zh. 2006;52:110–118

 Supported by National Basic Research Program of China (No. 2006CB944006), the National Natural Science Foundation of China (No. 30671161), the Key Research Program of Zhejiang province (No. 2005C23021, No. 2006C13078), and the Key Research Program of the Bureau of Science and Technology of Hangzhou (No. 20061123B03).

PII: S0015-0282(07)01248-4

doi: 10.1016/j.fertnstert.2007.06.004

Fertility and Sterility
Volume 90, Issue 1 , Pages 92-96 , July 2008

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