Fertility and Sterility
Volume 90, Issue 1 , Pages 44-48 , July 2008

Key lipogenic gene expression can be decreased by estrogen in human adipose tissue

  • Lovisa Lundholm, Ph.D.

      Affiliations

    • Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden
    • Corresponding Author InformationReprint requests: Lovisa Lundholm, Department of Biosciences and Nutrition, Karolinska Institutet, Novum, SE-141 57 Huddinge, Sweden (FAX: +46 8 774 55 38).
    • ,
  • Hong Zang, M.D., Ph.D.

      Affiliations

    • Department of Obstetrics and Gynecology, Karolinska University Hospital, Stockholm, Sweden
    • ,
  • Angelica Lindén Hirschberg, M.D., Ph.D.

      Affiliations

    • Department of Obstetrics and Gynecology, Karolinska University Hospital, Stockholm, Sweden
    • ,
  • Jan-Åke Gustafsson, M.D., Ph.D.

      Affiliations

    • Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden
    • ,
  • Peter Arner, M.D., Ph.D.

      Affiliations

    • Department of Medicine, Karolinska University Hospital, Huddinge, Sweden
    • ,
  • Karin Dahlman-Wright, Ph.D.

      Affiliations

    • Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden

Received 11 December 2006 ,Revised 18 April 2007 ,Accepted 23 May 2007.

References 

  1. Lovejoy JC. The menopause and obesity. Prim Care. 2003;30:317–325
  2. Crawford SL, Casey VA, Avis NE, McKinlay SM. A longitudinal study of weight and the menopause transition: results from the Massachusetts Women's Health Study. Menopause. 2000;7:96–104
  3. Guthrie JR, Dennerstein L, Taffe JR, Lehert P, Burger HG. The menopausal transition: a 9-year prospective population-based study. The Melbourne Women's Midlife Health Project. Climacteric. 2004;7:375–389
  4. Mattiasson I, Rendell M, Tornquist C, Jeppsson S, Hulthen UL. Effects of estrogen replacement therapy on abdominal fat compartments as related to glucose and lipid metabolism in early postmenopausal women. Horm Metab Res. 2002;34:583–588
  5. D'Eon TM, Souza SC, Aronovitz M, Obin MS, Fried SK, Greenberg AS. Estrogen regulation of adiposity and fuel partitioning. Evidence of genomic and nongenomic regulation of lipogenic and oxidative pathways. J Biol Chem. 2005;280:35983–35991
  6. Lundholm L, Moverare S, Steffensen KR, Nilsson M, Otsuki M, Ohlsson C, et al. Gene expression profiling identifies liver X receptor alpha as an estrogen-regulated gene in mouse adipose tissue. J Mol Endocrinol. 2004;32:879–892
  7. Dahlman-Wright K, Cavailles V, Fuqua SA, Jordan VC, Katzenellenbogen JA, Korach KS, et al. International Union of Pharmacology. LXIV. Estrogen receptors. Pharmacol Rev. 2006;58:773–781
  8. Heine PA, Taylor JA, Iwamoto GA, Lubahn DB, Cooke PS. Increased adipose tissue in male and female estrogen receptor-alpha knockout mice. Proc Natl Acad Sci U S A. 2000;97:12729–12734
  9. Roesch DM. Effects of selective estrogen receptor agonists on food intake and body weight gain in rats. Physiol Behav. 2006;87:39–44
  10. Dieudonne MN, Leneveu MC, Giudicelli Y, Pecquery R. Evidence for functional estrogen receptors alpha and beta in human adipose cells: regional specificities and regulation by estrogens. Am J Physiol Cell Physiol. 2004;286:C655–C661
  11. Zang H, Carlstrom K, Arner P, Hirschberg AL. Effects of treatment with testosterone alone or in combination with estrogen on insulin sensitivity in postmenopausal women. Fertil Steril. 2006;86:136–144
  12. Kolaczynski JW, Morales LM, Moore JH, Considine RV, Pietrzkowski Z, Noto PF, et al. A new technique for biopsy of human abdominal fat under local anaesthesia with Lidocaine. Int J Obes Relat Metab Disord. 1994;18:161–166
  13. Yoder PJ, Blackford JU, Waller NG, Kim G. Enhancing power while controlling family-wise error: an illustration of the issues using electrocortical studies. J Clin Exp Neuropsychol. 2004;26:320–331
  14. Mao J, DeMayo FJ, Li H, Abu-Elheiga L, Gu Z, Shaikenov TE, et al. Liver-specific deletion of acetyl-CoA carboxylase 1 reduces hepatic triglyceride accumulation without affecting glucose homeostasis. Proc Natl Acad Sci U S A. 2006;103:8552–8557
  15. Loftus TM, Jaworsky DE, Frehywot GL, Townsend CA, Ronnett GV, Lane MD, et al. Reduced food intake and body weight in mice treated with fatty acid synthase inhibitors. Science. 2000;288:2379–2381
  16. Dobrzyn A, Ntambi JM. Stearoyl-CoA desaturase as a new drug target for obesity treatment. Obes Rev. 2005;6:169–174
  17. Nakamura MT, Nara TY. Structure, function, and dietary regulation of delta6, delta5, and delta9 desaturases. Annu Rev Nutr. 2004;24:345–376
  18. Misso ML, Jang C, Adams J, Tran J, Murata Y, Bell R, et al. Differential expression of factors involved in fat metabolism with age and the menopause transition. Maturitas. 2005;51:299–306
  19. Gao H, Bryzgalova G, Hedman E, Khan A, Efendic S, Gustafsson JA, et al. Long-term administration of estradiol decreases expression of hepatic lipogenic genes and improves insulin sensitivity in ob/ob mice: a possible mechanism is through direct regulation of signal transducer and activator of transcription 3. Mol Endocrinol. 2006;20:1287–1299

 Supported by grants from the Golje Memorial Foundation, Swedish Research Council, Swedish Cancer Fund, Novo Nordisk Foundation, and the Swedish Diabetes Association.

 Dr. Gustafsson is a consultant to, deputy board member of, shareholder of, and receiver of grants from Karo Bio.

 Present address for Hong Zhang, M.D., Ph.D., is Department of Obstetrics and Gynecology, The First Affiliated Hospital of Dalian Medical University, Dalian, China.

PII: S0015-0282(07)01259-9

doi: 10.1016/j.fertnstert.2007.06.011

Fertility and Sterility
Volume 90, Issue 1 , Pages 44-48 , July 2008

Article Tools

* Image Usage & Resolution