Fertility and Sterility
Volume 89, Issue 6 , Pages 1777-1780 , June 2008

Genetic polymorphisms of glutathione S-transferase T1 (GSTT1) and alterations of sex hormones in filling-station workers

  • Mostafa Saadat, Ph.D.

      Affiliations

    • Corresponding Author InformationReprint requests: Mostafa Saadat, Ph.D., Shiraz University, Department of Biology, Char-rah Adabiyate, Shiraz, Fars 71454, Iran (FAX: +98-711-2280926).
    • ,
  • Nasrin Monzavi, M.Sc.

Received 7 March 2007 ,Revised 6 June 2007 ,Accepted 6 June 2007.

References 

  1. Ansari-Lari M, Saadat M, Hadi N. Modulation of hematology changes by polymorphism of glutathione S-transferase M1 and T1. Biochem Biophys Res Commun. 2003;312:299–302
  2. Ansari-Lari M, Saadat M, Hadi N. Influence of GSTT1 null genotype on the offspring sex ratio of gasoline filling station workers. J Epidemiol Commun Health. 2004;58:393–394
  3. James WH. Offspring sex ratio at birth as markers of paternal endocrine disruption. Environ Res. 2006;100:77–85
  4. Grant VJ. Could maternal testosterone levels govern mammalian sex ratio deviations?. J Theor Biol. 2007;246:708–719
  5. Pemble S, Schroeder KR, Spencer SR, Meyer DJ, Hallier E, Bolt M, et al. Human glutathione S-transferase theta (GSTT1): cDNA cloning and the characterization of a genetic polymorphism. Biochem J. 1994;300:271–276
  6. Kolm RH, Danielson UH, Zhang Y, Talalay P, Mannervik B. Isothiocyanates as substrates for human glutathione transferases: structure-activity studies. Biochem J. 1995;311:453–459
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  8. Bolit HM, Their R. Relevance of the deletion polymorphisms of the glutathione S-transferases GSTT1 and GSTM1 in pharmacology and toxicology. Curr Drug Metab. 2006;7:613–628
  9. Saadat M, Bahaoddini A, Ansari-Lari M. Possible effect of maternal hormones and GST genotypes on sex of offspring. Occup Envron Med. 2003;60:704
  10. Saadat M, Bahaoddini A, Mohabatkar H. Polymorphisms of glutathione S-transferase M1 and T1 modulate blood pressure of individuals chronically exposed to natural sour gas containing sulfur compounds. Biochem Biophys Res Commun. 2004;316:749–752
  11. Saadat M. Genetic polymorphisms of glutathione S-transferases M1 and T1 modulate hematological changes of individuals chronically exposed to natural sour gas. Biochem Biophys Res Commun. 2004;324:584–587
  12. Saadat I, Saadat M. Glutathione S-transferase M1 and T1 null genotypes and the risk of gastric and colorectal cancers. Cancer Lett. 2001;169:21–26
  13. Asawasinsopon R, Prapamontol T, Prakobvitayakit O, Vaneesorn Y, Mangklabruks A, Hock B. Plasma levels of DDT and their association with reproductive hormones in adult men from northern Thailand. Sci Total Environ. 2006;355:98–105
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  15. Jakobsson J, Ekstrom L, Inotsume N, Garle M, Lorentzon M, Ohlsson C, et al. Large differences in testosterone excretion in Korean and Swedish men are strongly associated with a UDP-glucuronosyl transferase 2B17 polymorphism. J Clin Endocrinol Metab. 2006;91:687–693
  16. Sautner SJ, Albertson B, Zhang GY, Zhang GH, Santulli M, Wang C, et al. Comparative rates of androgen production and metabolism in Caucasian and Chinese subjects. J Clin Endocrinol Metab 198;83:2104–2109.
  17. Egeland GM, Sweeney MH, Fingerhut MA, Wile KK, Schnorr TM, Halperin WE. Total serum testosterone and gonadotropins in workers exposed to dioxins. Am J Epidemiol. 1994;139:272–281
  18. Garry VF, Holland SE, Erickson LL, Burroughs BL. Male reproductive hormones and thyroid function in pesticide applicators in the Red River Valley of Minnesota. J Toxicol Environ Health A. 2003;66:965–986

 Supported in part by a Grant-in-Aid for Health Research from the NIOPDC and by a Grant-in-Aid for Promotion of Education and Science in Shiraz University, provided by the Ministry of Sciences, Research, and Technology of Iran.

PII: S0015-0282(07)01368-4

doi: 10.1016/j.fertnstert.2007.06.024

Fertility and Sterility
Volume 89, Issue 6 , Pages 1777-1780 , June 2008

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