Association of p53 codon 72 polymorphism with endometriosis

Ammendola, Maria; Gloria-Bottini, Fulvia; Sesti, Francesco; Piccione, Emilio; Bottini, Egidio

doi:10.1016/j.fertnstert.2007.06.051

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Volume 90, Issue 2 , Pages 406-408, August 2008

Association of p53 codon 72 polymorphism with endometriosis

Maria Ammendola, M.D.
- Division of Obstetrics and Gynecology, Department of Surgery, University of Rome “Tor Vergata,” School of Medicine, Rome, Italy
Fulvia Gloria-Bottini, M.D.
- Division of Human Population Biopathology and Environmental Pathology, Department of Biopathology and Imaging Diagnostics, University of Rome “Tor Vergata,” School of Medicine, Rome, Italy
- Reprint requests: Fulvia Gloria-Bottini, M.D., Department of Biopathology and Imaging Diagnostics, University of Rome “Tor Vergata,” Via Montpellier 1, 00133 Rome, Italy (FAX: 39-0672596028).
Francesco Sesti, M.D.
- Division of Obstetrics and Gynecology, Department of Surgery, University of Rome “Tor Vergata,” School of Medicine, Rome, Italy
Emilio Piccione, M.D.
- Division of Obstetrics and Gynecology, Department of Surgery, University of Rome “Tor Vergata,” School of Medicine, Rome, Italy
Egidio Bottini, M.D.
- Division of Human Population Biopathology and Environmental Pathology, Department of Biopathology and Imaging Diagnostics, University of Rome “Tor Vergata,” School of Medicine, Rome, Italy

Received 5 October 2006; received in revised form 16 June 2007; accepted 18 June 2007. published online 10 October 2007.

Objective

To study the association of endometriosis with p53 codon 72 polymorphism in the population of central Italy and to search for possible interaction with the PTPN22 polymorphism.

Design

Study of p53 and PTPN22 polymorphisms in women with endometriosis. Analysis of PTPN22 genotype distribution in relation to p53 genotypes.

Setting

Department of Obstetrics and Gynecology of the University of Rome “Tor Vergata.”

Patient(s)

The study included 129 women with endometriosis and 147 controls from the Caucasian population of central Italy.

Intervention(s)

None.

Main Outcome Measure(s)

Evaluation of risk for endometriosis.

Result(s)

No significant difference in the distribution of p53 codon 72 genotypes was observed between endometriosis patients and controls. An interaction between p53 and PTPN22 was observed: a protective action by the Arg/Arg genotype against endometriosis seems to be present only in carriers of the ^∗T allele of PTPN22.

Conclusion(s)

The negative association between the Arg/Arg genotype of p53 codon 72 found in Chinese people has not been observed in Japanese and Italian populations. Interaction with genes showing different allele frequencies among ethnic groups could be responsible for the differences reported among human populations concerning the relationship between p53 and susceptibility to endometriosis.

Key Words: Endometriosis, p53 polymorphism, PTPN22 polymorphism