Fertility and Sterility
Volume 90, Issue 2 , Pages 315-321 , August 2008

Relationship between women's age and basal follicle-stimulating hormone levels with aneuploidy risk in in vitro fertilization treatment

  • Meen-Yau Thum, M.D.

      Affiliations

    • Corresponding Author InformationReprint requests: Meen-Yau Thum, M.D., Lister Fertility Clinic, Lister Hospital, Chelsea Bridge Road, London, SW1W 8RH, United Kingdom (FAX: 020-7259-9039).
    • ,
  • Hossam I. Abdalla, F.R.C.O.G.
    • ,
  • Deborah Taylor, Ph.D.

Received 29 January 2007 ,Revised 20 June 2007 ,Accepted 20 June 2007.

References 

  1. Creus M, Penarrubia J, Farbregues F, Vidal E, Carmona F, Casamitjana R, et al. Day 3 serum Inhibin and FSH and age as predictors of assisted reproduction treatment outcome. Hum Reprod. 2000;15:2341–2346
  2. Lass A, Gerrard A, Abusheikha N, Akagbosu F, Brinsden P. IVF performance of women who have fluctuating early follicular FSH levels. J Assist Reprod Genet. 2000;17:566–573
  3. Sharif K, Elgendy M, Lashen H, Afnan M. Age and basal follicle stimulating hormone as predictors of in vitro fertilisation outcome. Br J Obstet Gynaecol. 1998;105:107–112
  4. Balasch L, Creus M, Fabregues F, Carmona F, Casamitjana R, Ascoso C, et al. Inhibin, follicle-stimulating hormone, and age as predictors of ovarian response in in vitro fertilization cycles stimulated with gonadotrophin-releasing hormone agonist-gonadotrophin treatment. Am J Obstet Gynecol. 1996;175:1226–1230
  5. Bancsi LF, Broekmans FJ, Mol BW, Habbema JD, te Velde ER. Performance of basal follicle-stimulating hormone in the prediction of poor ovarian response and failure to become pregnant after in vitro fertilization: a meta-analysis. Fertil Steril. 2003;79:1091–1100
  6. Van Montfrans JM, Hoek A, van Hooff MHA, de Koning CH, Tonch N, Lambalk CB. Predictive value of basal follicle-stimulating hormone concentrations in a general subfertility population. Fertil Steril. 2000;74:97–103
  7. Abdalla H, Thum MY. An elevated basal FSH reflects a quantitative rather than qualitative decline of the ovarian reserve. Hum Reprod. 2004;19:893–898
  8. van Rooij IAJ, Bansi L, Broekmans FJM, Looman C, Habbema J, te Velde ER. Women older than 40 years of age and those with elevated follicle-stimulating hormone levels differ in poor response rate and embryo quality in in vitro fertilization. Fertil Steril. 2003;79:482–488
  9. Esposito MA, Coutifaris C, Barnhart KT. A moderately elevated day 3 FSH concentration has limited predictive value, especially in younger women. Hum Reprod. 2002;17:118–123
  10. Levi AJ, Raynault MF, Bergh PA, Drews MR, Miller BT, Scott RT. Reproductive outcome in patients with diminished ovarian reserve. Fertil Steril. 2001;76:666–669
  11. El-Toukhy T, Khalaf Y, Hart R, Taylor A, Braude P. Young age does not protect against the adverse effects of reduced ovarian reserve—an eight year study. Hum Reprod. 2002;17:1519–1524
  12. Nasseri A, Mukherjee T, Grifo JA, Noyes N, Krey L, Copperman AB. Elevated day 3 serum follicle stimulating hormone and/or estradiol may predict fetal aneuploidy. Fertil Steril. 1999;71:715–718
  13. Taranissi M, El-Toukhy T, Verlinsky Y. Influence of maternal age on the outcome of PGD for aneuploidy screening in patients with recurrent implantation failure. Reprod Biomed Online. 2005;10:628–632
  14. Platteau P, Staessen C, Michiels A, Van Steirteghem A, Liebaers I, Devroey P. Preimplantation genetic diagnosis for aneuploidy screening in women older than 37 years. Fertil Steril. 2005;84:319–324
  15. Verlinsky Y, Tur-Kaspa I, Cieslak J, Bernal A, Morris R, Taranissi M, et al. Preimplantation testing for chromosomal disorders improves reproductive outcome of poor-prognosis patients. Reprod Biomed Online. 2005;11:219–225
  16. Munne S, Alikani M, Tomkin G, Grifo J, Cohen J. Embryo morphology, developmental rates, and maternal age are correlated with chromosome abnormalities. Fertil Steril. 1995;64:382–391
  17. Staessen C, Platteau P, Van Assche E, Michiels A, Tournaye H, Camus M, et al. Comparison of blastocyst transfer with or without preimplantation genetic diagnosis for aneuploidy screening in couples with advanced maternal age: a prospective randomized controlled trial. Hum Reprod. 2004;19:2849–2858
  18. Kuliev A, Verlinsky Y. Current features of preimplantation genetic diagnosis. Reprod Biomed Online. 2002;5:294–299
  19. Harper JC, Coonen E, Ramaekers FC, Delhanty JD, Handyside AH, Winston RM, et al. Identification of the sex of human preimplantation embryos in two hours using an improved spreading method and fluorescent in-situ hybridization (FISH) using directly labelled probes. Hum Reprod. 1994;9:721–724
  20. Armitage P, Berry G. Statistic method in medical research. Oxford: Blackwell Scientific; 1994;179–82
  21. Barnhart K, Osherof J. Follicle stimulating hormone as a predictor of fertility. Curr Opin Obstet Gynecol. 1998;10:227–232
  22. Scott RT, Hofmann GE, Oehinger S, Muasher SJ. Intercycle variability of day 3 follicle-stimulating hormone levels and its effect on stimulation quality in in vitro fertilization. Fertil Steril. 1990;54:297–302
  23. Sharif K, Afnan M. The IVF league tables: time for a reality check. Hum Reprod. 2003;18:483–485
  24. Abdalla H, Thum MY. Repeated testing of basal FSH levels has no predictive value for IVF treatment outcome in women with elevated basal FSH. Hum Reprod. 2006;21:171–174
  25. Gianaroli L, Magli MC, Ferraretti AP, Munne S. Preimplantation diagnosis for aneuploidies in patients undergoing in vitro fertilization with a poor prognosis: identification of the categories for which it should be proposed. Fertil Steril. 1999;72:837–844
  26. Delhanty JD. Mechanisms of aneuploidy induction in human oogenesis and early embryogenesis. Cytogenet Genome Res. 2005;111:237–244
  27. Munne S, Sandalinas M, Escudero T, Marquez C, Cohen J. Chromosome mosaicism in cleavage-stage human embryos: evidence of a maternal age effect. Reprod Biomed Online. 2002;4:223–232

PII: S0015-0282(07)01418-5

doi: 10.1016/j.fertnstert.2007.06.063

Fertility and Sterility
Volume 90, Issue 2 , Pages 315-321 , August 2008

Article Tools