Weak linkage in androgen receptor: identification of mutation-prone points
Received 6 June 2007; received in revised form 26 June 2007; accepted 26 June 2007. published online 12 October 2007.
Objective
Mutation within androgen receptor (AR) can be seen. Presently, prediction of protein nanostructure and function is a great challenge in the proteomics and structural genomics era. To identify the points vulnerable to mutation is a new trend to expand the knowledge on disorders in genomic and proteomic level of diseases.
Design
The author performed a bioinformatics analysis to study the determined positions that correspond with peptide motifs in the amino acid sequence of AR.
Intervention(s)
To identify the weak linkages in AR, a new bioinformatics tool, GlobPlot, was used.
Main Outcome Measure(s)
Mutation-sensitive points.
Result(s)
According to this work, the positions resistant to mutation are identified.
Conclusion(s)
Based on this study, the weak linkages in AR can be identified and can be good information for the prediction of possible new mutations that can result in phenotype abnormality. In addition, the results from this study can be good information for further research on the diagnosis for AR abnormalities and new treatment.
Department of Laboratory Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
Reprint requests: Viroj Wiwanitkit, M.D., Department of Laboratory Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand 10330 (FAX: 662-256 4136).
ABSTRACT