Fertility and Sterility
Volume 90, Issue 3 , Pages 714-726 , September 2008

Does high body mass index increase the risk of miscarriage after spontaneous and assisted conception? A meta-analysis of the evidence

  • Mostafa Metwally, M.R.C.O.G.

      Affiliations

    • Corresponding Author InformationReprint requests: Mostafa Metwally, M.R.C.O.G., The Academic Unit of Reproductive and Developmental Medicine, The University of Sheffield, The Jessop Wing, Tree Root Walk, S10 4ED, Sheffield, United Kingdom (FAX: 44-114-2261074).
  • ,
  • Kee J. Ong, F.R.A.N.Z.O.G.
  • ,
  • William L. Ledger, D.Phil.
  • ,
  • Tin Chiu Li, Ph.D.

Received 1 December 2006 ,Revised 5 July 2007 ,Accepted 5 July 2007.

References 

  1. Linne Y. Effects of obesity on women's reproduction and complications during pregnancy. Obes Rev. 2004;5:137–143
  2. Hamilton-Fairley D, Kiddy D, Watson H, Paterson C, Franks S. Association of moderate obesity with a poor pregnancy outcome in women with polycystic ovary syndrome treated with low dose gonadotrophin. Br J Obstet Gynaecol. 1992;99:128–131
  3. Lashen H, Fear K, Sturdee DW. Obesity is associated with increased risk of first trimester and recurrent miscarriage: matched case-control study. Hum Reprod. 2004;19:1644–1646
  4. Fedorcsak P, Dale PO, Storeng R, Ertzeid G, Bjercke S, Oldereid N, et al. Impact of overweight and underweight on assisted reproduction treatment. Hum Reprod. 2004;19:2523–2528
  5. Lashen H, Ledger W, Bernal AL, Barlow D. Extremes of body mass do not adversely affect the outcome of superovulation and in-vitro fertilization. Hum Reprod. 1999;14:712–715
  6. Fedorcsak P, Storeng R, Dale PO, Tanbo T, Abyholm T. Obesity is a risk factor for early pregnancy loss after IVF or ICSI. Acta Obstet Gynecol Scand. 2000;79:43–48
  7. Bellver J, Rossal LP, Bosch E, Zuniga A, Corona JT, Melendez F, et al. Obesity and the risk of spontaneous abortion after oocyte donation. Fertil Steril. 2003;79:1136–1140
  8. Fedorcsak P, Dale PO, Storeng R, Tanbo T, Abyholm T. The impact of obesity and insulin resistance on the outcome of IVF or ICSI in women with polycystic ovarian syndrome. Hum Reprod. 2001;16:1086–1091
  9. Clark AM, Thornley B, Tomlinson L, Galletley C, Norman RJ. Weight loss in obese infertile women results in improvement in reproductive outcome for all forms of fertility treatment. Hum Reprod. 1998;13:1502–1505
  10. Roth D, Grazi RV, Lobel SM. Extremes of body mass index do not affect first-trimester pregnancy outcome in patients with infertility. Am J Obstet Gynecol. 2003;188:1169–1170
  11. Thum M-Y, Gafar A, Faris R, Wren M, Ogunyemi T, Abdalla H. The influence of body mass index on in vitro fertilization treatment outcome, risk of miscarriage, and pregnancy outcome. Fertil Steril. 2003;80(Suppl 3):155–156
  12. Mulders AG, Laven JS, Eijkemans MJ, Hughes EG, Fauser BC. Patient predictors for outcome of gonadotrophin ovulation induction in women with normogonadotrophic anovulatory infertility: a meta-analysis. Hum Reprod Update. 2003;9:429–449
  13. Bohrer M, Kemmann E. Risk factors for spontaneous abortion in menotropin-treated women. Fertil Steril. 1987;48:571–575
  14. al-Ansary LA, Babay ZA. Risk factors for spontaneous abortion: a preliminary study on Saudi women. J R Soc Health. 1994;114:188–193
  15. Franks S, Hamilton-Fairley D. [The role of body weight and metabolic anomalies in ovulation induction]. Contracept Fertil Sex. 1994;22:178–179
  16. Wang JX, Davies MJ, Norman RJ. Polycystic ovarian syndrome and the risk of spontaneous abortion following assisted reproductive technology treatment. Hum Reprod. 2001;16:2606–2609
  17. Al-Azemi M, Omu FE, Omu AE. The effect of obesity on the outcome of infertility management in women with polycystic ovary syndrome. Arch Gynecol Obstet. 2004;270:205–210
  18. Balen AH, Platteau P, Andersen AN, Devroey P, Sorensen P, Helmgaard L, et al. The influence of body weight on response to ovulation induction with gonadotrophins in 335 women with World Health Organization group II anovulatory infertility. BJOG. 2006;113:1195–1202
  19. Dokras A, Baredziak L, Blaine J, Syrop C, VanVoorhis BJ, Sparks A. Obstetric outcomes after in vitro fertilization in obese and morbidly obese women. Obstet Gynecol. 2006;108:61–69
  20. Loveland JB, McClamrock HD, Malinow AM, Sharara FI. Increased body mass index has a deleterious effect on in vitro fertilization outcome. J Assist Reprod Genet. 2001;18:382–386
  21. Styne-Gross A, Elkind-Hirsch K, Scott RT. Obesity does not impact implantation rates or pregnancy outcome in women attempting conception through oocyte donation. Fertil Steril. 2005;83:1629–1634
  22. van Swieten EC, van der Leeuw-Harmsen L, Badings EA, van der Linden PJ. Obesity and Clomiphene Challenge Test as predictors of outcome of in vitro fertilization and intracytoplasmic sperm injection. Gynecol Obstet Invest. 2005;59:220–224
  23. Wang JX, Davies MJ, Norman RJ. Obesity increases the risk of spontaneous abortion during infertility treatment. Obes Res. 2002;10:551–554
  24. Winter E, Wang J, Davies MJ, Norman R. Early pregnancy loss following assisted reproductive technology treatment. Hum Reprod. 2002;17:3220–3223
  25. Wittemer C, Ohl J, Bailly M, Bettahar-Lebugle K, Nisand I. Does body mass index of infertile women have an impact on IVF procedure and outcome?. J Assist Reprod Genet. 2000;17:547–552
  26. Bellver J, Melo MA, Bosch E, Serra V, Remohi J, Pellicer A. Obesity and poor reproductive outcome: the potential role of the endometrium. Fertil Steril. 2007;88:446–451
  27. Wang JX, Warnes GW, Davies MJ, Norman RJ. Overweight infertile patients have a higher fecundity than normal-weight women undergoing controlled ovarian hyperstimulation with intrauterine insemination. Fertil Steril. 2004;81:1710–1712
  28. World Health Organization . Obesity: preventing and managing the global epidemic. Report of a WHO consultation on obesity. Geneva, Switzerland: World Health Organization; 1999;
  29. Hourvitz A, Lerner-Geva L, Elizur SE, Baum M, Levron J, David B, et al. Role of embryo quality in predicting early pregnancy loss following assisted reproductive technology. Reprod Biomed Online. 2006;13:504–509
  30. van der Spuy ZM, Dyer SJ. The pathogenesis of infertility and early pregnancy loss in polycystic ovary syndrome. Best Pract Res Clin Obstet Gynaecol. 2004;18:755–771
  31. Homburg R. Pregnancy complications in PCOS. Best Pract Res Clin Endocrinol Metab. 2006;20:281–292
  32. Higgins JPT, Green S, eds. Publication bias and funnel plots. Cochrane Handbook for systematic reviews of interventions 4.2.5. [updated May 2005]; Section 8.11.1. In: The Cochrane Library Issue 3, 2005. Chichester, UK: John Wiley & sons, Ltd.

PII: S0015-0282(07)01525-7

doi: 10.1016/j.fertnstert.2007.07.1290

Fertility and Sterility
Volume 90, Issue 3 , Pages 714-726 , September 2008