Fertility and Sterility
Volume 90, Issue 3 , Pages 737-743 , September 2008

Evaluation of anti-Müllerian hormone as a test for the prediction of ovarian reserve

  • Janet Kwee, M.D.

      Affiliations

    • Division of Reproductive Endocrinology and Fertility and the IVF Centre, department of Obstetrics and Gynaecology, Vrije Universiteit Medical Centre, Amsterdam, The Netherlands
    • Corresponding Author InformationReprint requests: Janet Kwee, M.D., Division of Reproductive Medicine, Vrije Universiteit Medical Centre, PO Box 7057, 1007 MB Amsterdam, The Netherlands (FAX: 31-20-4440045).
    • ,
  • Roel Schats, M.D., Ph.D.

      Affiliations

    • Division of Reproductive Endocrinology and Fertility and the IVF Centre, department of Obstetrics and Gynaecology, Vrije Universiteit Medical Centre, Amsterdam, The Netherlands
    • ,
  • Joseph McDonnell, M.Sc.

      Affiliations

    • Division of Reproductive Endocrinology and Fertility and the IVF Centre, department of Obstetrics and Gynaecology, Vrije Universiteit Medical Centre, Amsterdam, The Netherlands
    • ,
  • Axel Themmen, Ph.D.

      Affiliations

    • Department of Internal Medicine, Erasmus Medical Centre, Rotterdam, The Netherlands
    • ,
  • Frank de Jong, Ph.D.

      Affiliations

    • Department of Internal Medicine, Erasmus Medical Centre, Rotterdam, The Netherlands
    • ,
  • Cornelis Lambalk, M.D., Ph.D.

      Affiliations

    • Division of Reproductive Endocrinology and Fertility and the IVF Centre, department of Obstetrics and Gynaecology, Vrije Universiteit Medical Centre, Amsterdam, The Netherlands

Received 18 December 2006 ,Revised 5 July 2007 ,Accepted 5 July 2007.

References 

  1. Broekmans FJ, Kwee J, Hendriks D, Mol BW, Lambalk CB. A systematic review of tests predicting ovarian reserve and IVF outcome. Hum Reprod Update. 2006;12:685–718
  2. Van Rooij IA, Broekmans FJ, te Velde ER, Fauser BC, Bancsi LF, de Jong FH, et al. Serum anti-Mullerian hormone levels: a novel measure of ovarian reserve. Hum Reprod. 2002;17:3065–3071
  3. Van Rooij IA, Tonkelaar I, Broekmans FJ, Looman CW, Scheffer GJ, de Jong FH, et al. Anti-mullerian hormone is a promising predictor for the occurrence of the menopausal transition. Menopause. 2004;11:601–606
  4. Van Rooij IA, Broekmans FJ, Scheffer GJ, Looman CW, Habbema JD, de Jong FH, et al. Serum antimullerian hormone levels best reflect the reproductive decline with age in normal women with proven fertility: a longitudinal study. Fertil Steril. 2005;83:979–987
  5. Fanchin R, Schonauer LM, Righini C, Frydman N, Frydman R, Taieb J. Serum anti-Mullerian hormone dynamics during controlled ovarian hyperstimulation. Hum Reprod. 2003;18:328–332
  6. Seifer DB, Mac Laughlin DT, Christian BP, Feng B, Shelden RM. Early follicular serum mullerian-inhibiting substance levels are associated with ovarian response during assisted reproductive technology cycles. Fertil Steril. 2002;77:468–471
  7. Behringer RR, Finegold MJ, Cate RL. Mullerian-inhibiting substance function during mammalian sexual development. Cell. 1994;79:415–425
  8. Vigier B, Tran D, Legeai L, Bezard J, Josso N. Origin of anti-Mullerian hormone in bovine freemartin fetuses. J Reprod Fertil. 1984;70:473–479
  9. Durlinger AL, Kramer P, Karels B, de Jong FH, Uilenbroek JT, Grootegoed JA, et al. Control of primordial follicle recruitment by anti-Mullerian hormone in the mouse ovary. Endocrinology. 1999;140:5789–5796
  10. Durlinger AL, Visser JA, Themmen AP. Regulation of ovarian function: the role of anti-Mullerian hormone. Reproduction. 2002;124:601–609
  11. Weenen C, Laven JS, Von Bergh AR, Cranfield M, Groome NP, Visser JA, et al. Anti-Müllerian hormone expression pattern in the human ovary: potential implications for initial and cyclic follicle recruitment. Mol Hum Reprod. 2004;10:77–83
  12. Kevenaar ME, Meerasahib MF, Kramer P, van de Lang-Born BM, de Jong FH, Groome NP, et al. Serum anti-mullerian hormone levels reflect the size of the primordial follicle pool in mice. Endocrinology. 2006;147:3228–3234
  13. Gougeon A. Caracteres qualitatifs et quantitatifs de la population folliculaire dans l'ovaire humaine adulte. Contracept Fertil Sex. 1994;12:527–535
  14. de Vet A, Laven JS, de Jong FH, Themmen APN, Fauser BC. Antimüllerian hormone serum levels: a putative marker for ovarian aging. Fertil Steril. 2002;77:357–362
  15. Hehenkamp JK, Loomans CWN, Themmen APN, de Jong FH, te Velde ER, Broekmans FJM. Anti-Mullerian hormone levels in the spontaneous menstrual cycle do not show substantial fluctuation. J Clin Endocrinol Metab. 2006;10:4057–4063
  16. La Marca A, Stabile G, Artenisio AC, Volpe A. Serum anti-Mullerian hormone throughout the human menstrual cycle. Hum Reprod. 2006;21:3103–3107
  17. Kwee J, Elting MW, Schats R, Bezemer PD, Lambalk CB, Schoemaker J. Comparison of endocrine tests with respect to their predictive value on the outcome of ovarian hyperstimulation in IVF treatment: results of a prospective randomized study. Hum Reprod. 2003;18:1422–1427
  18. Kwee J, Schats R, McDonnell J, Schoemaker J, Lambalk CB. The clomiphene citrate challenge test versus the exogenous follicle-stimulating hormone ovarian reserve test as a single test for identification of low responders and hyperresponders to in vitro fertilization. Fertil Steril. 2006;85:1714–1722
  19. Kwee J, Elting M, Schats R, McDonnell J, Lambalk CB. Ovarian volume and antral follicle count for the prediction of low and hyper responders with in vitro fertilization. Reprod Biol Endocrinol. 2007;15:5–9
  20. Visser JA, deJong FH, Laven JSE, Themmen APN. Anti-Mullerian hormone: a new marker for ovarian function. Reproduction. 2006;1:1–9

 Supported by an unrestricted grant from Serono (Geneva, Switzerland).

PII: S0015-0282(07)01530-0

doi: 10.1016/j.fertnstert.2007.07.1293

Fertility and Sterility
Volume 90, Issue 3 , Pages 737-743 , September 2008

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