Fertility and Sterility
Volume 90, Issue 3 , Pages 604-612 , September 2008

Effect of hyaluronan-enriched transfer medium on implantation and pregnancy rates after day 3 and day 5 embryo transfers: a prospective randomized study

Received 29 January 2007 ,Revised 5 July 2007 ,Accepted 5 July 2007.

References 

  1. Gardner DK, Lane M, Calderon I, Leeton J. Environment of the preimplantation human embryo in vivo: metabolite analysis of oviduct and uterine fluids and metabolism of cumulus cells. Fertil Steril. 1996;65:349–353
  2. Gardner DK. Changes in requirements and utilization of nutrients during mammalian preimplantation embryo development and their significance in embryo culture. Theriogenology. 1998;49:83–102
  3. Gardner DK, Surrey E, Minjarez D, Leitz A, Stevens J, Schoolcraft WB. Single blastocyst transfer: a prospective randomized trial. Fertil Steril. 2004;81:551–555
  4. Gerris JM. Single embryo transfer and IVF/ICSI outcome: a balanced appraisal. Hum Reprod Update. 2005;11:105–121
  5. Bavister BD. Substitution of a synthetic polymer for protein in a mammalian gamete culture system. J Exp Zool. 1981;217:45–51
  6. Bavister BD. Culture of preimplantation embryos: facts and artifacts. Hum Reprod Update. 1995;1:91–148
  7. Yanagishita M. Proteoglycans and hyaluronan in female reproductive organs. Proteoglycans. 1994;70:179–190
  8. Zorn TM, Pinhal MA, Nader HB, Carvalho JJ, Abrahamsohn PA, Dietrich CP. Biosynthesis of glycosaminoglycans in the endometrium during the initial stages of pregnancy of the mouse. Cell Mol Biol (Noisy-le-grand). 1995;41:97–106
  9. Furnus CC, Valcarcel A, Dulout FN, Errecalde AL. The hyaluronic acid receptor (CD44) is expressed in bovine oocytes and early stage embryos. Theriogenology. 2003;60:1633–1644
  10. Meinert M, Eriksen GV, Petersen AC, Helmig RB, Laurent C, Uldbjerg N, et al. Proteoglycans and hyaluronan in human fetal membranes. Am J Obstet Gynecol. 2001;184:679–685
  11. Gardner DK, Rodriegez-Martinez H, Lane M. Fetal development after transfer is increased by replacing protein with the glycosaminoglycan hyaluronan for mouse embryo culture and transfer. Hum Reprod. 1999;14:2575–2580
  12. Gardner DK, Lane M, Stevens J, Schoolcraft WB. Changing the start temperature and cooling rate in a slow-freezing protocol increases human blastocyst viability. Fertil Steril. 2003;79:407–410
  13. Balaban B, Urman B. Comparison of two sequential media for culturing cleavage-stage embryos and blastocysts: embryo characteristics and clinical outcome. Reprod Biomed Online. 2005;10:485–491
  14. Valojerdi MR, Karimian L, Yazdi PE, Gilani MA, Madani T, Baghestani AR. Efficacy of a human embryo transfer medium: a prospective, randomized clinical trial study. J Assist Reprod Genet. 2006;23:207–212
  15. Loutradi KE, Prassas I, Bili E, Sanopoulou T, Bontis I, Tarlatzis BC. Evaluation of a transfer medium containing high concentration of hyaluronan in human in vitro fertilization. Fertil Steril. 2007;87:48–52
  16. Dokras A, Sargent IL, Barlow DH. Human blastocyst grading: an indicator of developmental potential?. Hum Reprod. 1993;8:2119–2127
  17. Herrler A, von Rango U, Beier HM. Embryo-maternal signalling: how the embryo starts talking to its mother to accomplish implantation. Reprod Biomed Online. 2003;6:244–256
  18. Minas V, Loutradis D, Makrigiannakis A. Factors controlling blastocyst implantation. Reprod Biomed Online. 2005;10:205–216
  19. Makker A, Singh MM. Endometrial receptivity: clinical assessment in relation to fertility, infertility, and antifertility. Med Res Rev. 2006;26:699–746
  20. Makrigiannakis A, Minas V, Kalantaridou SN, Nikas G, Chrousos GP. Hormonal and cytokine regulation of early implantation. Trends Endocrinol Metab. 2006;17:178–185
  21. Schoolcraft W, Lane M, Stevens J, Gardner D. Increased hyaluronan concentration in the embryo transfer medium results in a significant increase in human embryo implantation rate. [Abstract] Fertil Steril. 2002;78:S5
  22. Balaban B, Isiklar A, Yakin K, Gursoy H, Urman B. Increased implantation rates in patients with recurrent implantation failures following the use of a new transfer medium enriched with hyaluronan. Hum Reprod. 2004;19:i6–i8
  23. Afify AM, Craig S, Paulino AF. Temporal variation in the distribution of hyaluronic acid, CD44s, and CD44v6 in the human endometrium across the menstrual cycle. Appl Immunohistochem Mol Morphol. 2006;14:328–333
  24. Campbell S, Swann HR, Aplin JD, Seif MW, Kimber SJ, Elstein M. CD44 is expressed throughout pre-implantation human embryo development. Hum Reprod. 1995;10:425–430
  25. Lane M, Maybach JM, Hooper K, Hasler JF, Gardner DK. Cryo-survival and development of bovine blastocysts are enhanced by culture with recombinant albumin and hyaluronan. Mol Reprod Dev. 2003;64:70–78
  26. Stojkovic M, Kolle S, Peinl S, Stojkovic P, Zakhartchenko V, Thompson JG, et al. Effects of high concentrations of hyaluronan in culture medium on development and survival rates of fresh and frozen-thawed bovine embryos produced in vitro. Reproduction. 2002;124:141–153
  27. Kim HS, Lee GS, Hyun SH, Nam DH, Lee SH, Jeong YW, et al. Embryotropic effect of glycosaminoglycans and receptors in development of porcine pre-implantation embryos. Theriogenology. 2005;63:1167–1180
  28. Turley E, Moore D. Hyaluronate binding proteins also bind to fibronectin, laminin and collagen. Biochem Biophys Res Commun. 1984;121:808–814
  29. West DC, Kumar S. Hyaluronan and angiogenesis. Ciba Found Symp. 1989;143:187–201[discussion: 201–7, 281–5]
  30. Rooney P, Kumar S, Ponting J, Wang M. The role of hyaluronan in tumour neovascularization (review). Int J Cancer. 1995;60:632–636
  31. Afify AM, Craig S, Paulino AF, Stern R. Expression of hyaluronic acid and its receptors, CD44s and CD44v6, in normal, hyperplastic, and neoplastic endometrium. Ann Diagn Pathol. 2005;9:312–318
  32. Meyer FA. Macromolecular basis of globular protein exclusion and of swelling pressure in loose connective tissue (umbilical cord). Biochim Biophys Acta. 1983;755:388–399
  33. Toole BP. Developmental role of hyaluronate. Connect Tissue Res. 1982;10:93–100
  34. Turley EA, Bowman P, Kytryk MA. Effects of hyaluronate and hyaluronate binding proteins on cell motile and contact behaviour. J Cell Sci. 1985;78:133–145
  35. Doillon CJ, Silver FH, Berg RA. Fibroblast growth on a porous collagen sponge containing hyaluronic acid and fibronectin. Biomaterials. 1987;8:195–200
  36. Knudson W. The role of CD44 as a cell surface hyaluronan receptor during tumor invasion of connective tissue. Front Biosci. 1998;3:d604–d615
  37. Carson DD, Dutt A, Tang JP. Glycoconjugate synthesis during early pregnancy: hyaluronate synthesis and function. Dev Biol. 1987;120:228–235

PII: S0015-0282(07)01531-2

doi: 10.1016/j.fertnstert.2007.07.1294

Fertility and Sterility
Volume 90, Issue 3 , Pages 604-612 , September 2008