Fertility and Sterility
Volume 90, Issue 3 , Pages 506-512 , September 2008

Support for embryonic stem cell research among infertility patients

  • Tarun Jain, M.D.

      Affiliations

    • Department of Obstetrics and Gynecology, University of Illinois Medical Center, Chicago, Illinois
    • Corresponding Author InformationReprint requests: Tarun Jain, M.D., Division of Reproductive Endocrinology and Infertility, University of Illinois at Chicago, 820 South Wood Street, M/C 808, Chicago, IL 60612 (FAX: 312-996-4238).
  • ,
  • Stacey A. Missmer, Sc.D.

      Affiliations

    • Department of Obstetrics, Gynecology, and Reproductive Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts
    • Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts
    • Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts

Received 6 March 2007 ,Revised 9 July 2007 ,Accepted 10 July 2007.

References 

  1. Trounson A. The production and directed differentiation of human embryonic stem cells. Endocr Rev. 2006;27:208–219
  2. Sonntag KC, Simantov R, Isacson O. Stem cells might reshape the prospect of Parkinson's disease therapy. Mol Brain Res. 2005;134:34–51
  3. Rubart M, Field LJ. Cardiac repair by embryonic stem-derived cells. Handb Exp Pharmacol. 2006;174:73–100
  4. Otonkoski T, Gao R, Lundin K. Stem cells in the treatment of diabetes. Ann Med. 2005;37:513–520
  5. McDonald JW, Becker D, Holekamp TF, Howard M, Liu S, Lu A, et al. Repair of the injured spinal cord and the potential of embryonic stem cell transplantation. J Neurotrauma. 2004;21:383–393
  6. Kaufman DS, Hanson ET, Lewis RL, Auerbach R, Thomson JA. Hematopoietic colony-forming cells derived from human embryonic stem cells. Proc Natl Acad Sci U S A. 2001;98:10716–10721
  7. Thomson JA, Itskovitz-Eldor J, Shapiro SS, Waknitz MA, Swiergiel JJ, Marshall VS, et al. Embryonic stem cell lines derived from human blastocysts. Science. 1998;282:1145–1147
  8. Steinbock B. Life before birth: the moral and legal status of embryos and fetuses. New York: Oxford University Press; 1992;
  9. Dickens BM, Cook RJ. Acquiring human embryos for stem-cell research. Int J Gynecol Obstet. 2007;96:67–71
  10. Jain T, Missmer SA, Hornstein MD. Trends in embryo-transfer practice and in outcomes of the use of assisted reproductive technology in the United States. N Engl J Med. 2004;350:1639–1645
  11. Hoffman DI, Zellman GL, Fair CC, Mayer JF, Zeitz JG, Gibbons WE, et al. Cryopreserved embryos in the United States and their availability for research. Fertil Steril. 2003;73:1063–1069
  12. Hampton T. Scientists, ethicists ponder challenges in moving stem cell research forward. JAMA. 2006;296:2542–2543
  13. Annas GJ. Ulysses and the fate of frozen embryos—reproduction, research, or destruction?. N Engl J Med. 2000;343:373–376
  14. Green RM. Benefiting from ‘evil’: an incipient problem in human stem cell research. Bioethics. 2002;16:544–556
  15. Wertz DC. Embryo and stem cell research in the United States: history and politics. Gene Ther. 2002;9:674–678
  16. ACOG Committee on Ethics . ACOG committee opinion no. 347, November 2006: using preimplantation embryos for research. Obstet Gynecol. 2006;108:1305–1317
  17. Ethics Committee of the American Society for Reproductive Medicine . Donating spare embryos for embryonic stem-cell research. Fertil Steril. 2002;78:957–960
  18. Bankowski BJ, Lyerly AD, Faden RR, Wallach EE. The social implications of embryo cryopreservation. Fertil Steril. 2005;84:823–832
  19. Rothman KJ, Greenland S. Modern epidemiology. 2nd ed.. Philadelphia: Lippincott-Raven; 1998;
  20. Greenland S. Modeling and variable selection in epidemiologic analysis. Am J Public Health. 1989;79:340–349
  21. Hosmer DW, Lemeshow S. Applied logistic regression. New York: John Wiley & Sons; 1989;
  22. Jain T, Hornstein MD. Disparities in access to infertility services in a state with mandated insurance coverage. Fertil Steril. 2005;84:221–223
  23. Jain T. Socioeconomic and racial disparities among infertility patients seeking care. Fertil Steril. 2006;85:876–881
  24. Grainger DA, Siefer DB, Frazier LF, Rall MJ, Tjaden BL, Merrill JC. Racial disparity in clinical outcomes from women using advanced reproductive technologies (ART): analysis of 80,196 ART cycles from the SART database 1999 and 2000. Fertil Steril. 2004;82:S37–S38
  25. Van Voorhis BJ, Grinstead DM, Sparks AE, Gerard JL, Weir RF. Establishment of a successful donor embryo program: medical, ethical, and policy issues. Fertil Steril. 1999;71:604–608
  26. Bjuresten K, Hovatta O. Donation of embryos for stem cell research—how many couples consent?. Hum Reprod. 2003;18:1353–1355
  27. McMahon CA, Gibson FL, Leslie GI, Saunders DM, Porter KA, Tennant CC. Embryo donation for medical research: attitudes and concerns of potential donors. Hum Reprod. 2003;18:871–877
  28. Newton CR, McDermid A, Tekpetey F, Tummon IS. Embryo donation: attitudes toward donation procedures and factors predicting willingness to donate. Hum Reprod. 2003;18:878–884
  29. Bangsboll S, Pinborg A, Andersen CY, Andersen AN. Patients' attitudes toward donation of surplus cryopreserved embryos for treatment or research. Hum Reprod. 2004;19:2415–2419
  30. Burton PJ, Sanders K. Patient attitudes to donation of embryos for research in Western Australia. Med J Aust. 2004;180:559–561
  31. Choudhary M, Haimes E, Herbert M, Stojkovic M, Murdoch AP. Demographic, medical and treatment characteristics associated with couples' decisions to donate fresh spare embryos for research. Hum Reprod. 2004;19:2091–2096
  32. Hammarberg K, Tinney L. Deciding the fate of supernumerary frozen embryos: a survey of couples' decisions and the factors influencing their choice. Fertil Steril. 2006;86:86–91
  33. Krones T, Neuwohner E, Bock K, Manolopoulos K, Tinneberg HR, Richter G. Attitudes of patients, healthcare professionals and ethicists toward embryonic stem cell research and donation of gametes and embryos in Germany. Reprod Biomed Online. 2006;13:607–617
  34. Lyerly AD, Steinhauser K, Namey E, Tulsky JA, Cook-Deegan R, Sugarman J, et al. Factors that affect infertility patients' decisions about disposition of frozen embryos. Fertil Steril. 2006;85:1623–1630
  35. Corbie-Smith G, Thomas SB, Williams MV, Moody-Ayers S. Attitudes and beliefs of African-Americans toward participation in medical research. J Gen Intern Med. 1999;14:537–546
  36. Boulware LE, Cooper LA, Ratner LE, LaVeist TA, Powe NR. Race and trust in the health care system. Public Health Rep. 2003;118:358–365
  37. Murthy VH, Krumholz HM, Gross CP. Participation in cancer clinical trials: race-, sex-, and age-based disparities. JAMA. 2004;291:2720–2726
  38. Halbert CH, Armstrong K, Gandy OH, Shaker L. Racial differences in trust in health care providers. Arch Intern Med. 2006;166:896–901
  39. King TE. Racial disparities in clinical trials. N Engl J Med. 2002;346:1400–1402
  40. National Institutes of Health . NIH guidelines on the inclusion of women and minorities as subjects in clinical research. Federal Register. 1994;59:14508–14513
  41. Schenker JG. Assisted reproductive practice: religious perspectives. Reprod Biomed Online. 2005;10:310–319
  42. The Vatican. Catechism of the Catholic Church. Article 6: the sixth commandment. Available at: http://www.vatican.va/archive/ccc_css/archive/catechism/p3s2c2a6.htm#2377. Accessed February 19, 2007.

PII: S0015-0282(07)02948-2

doi: 10.1016/j.fertnstert.2007.07.1311

Fertility and Sterility
Volume 90, Issue 3 , Pages 506-512 , September 2008