Fertility and Sterility
Volume 90, Issue 4 , Pages 988-993 , October 2008

Expression of cyclooxygenase-2 and vascular endothelial growth factor in ovarian endometriotic cysts and their relationship with angiogenesis

  • Seyit Temel Ceyhan, M.D.

      Affiliations

    • Department of Obstetrics and Gynecology, Gulhane Military Medical Academy and Medical School, Etlik, Ankara, Turkey
    • Corresponding Author InformationReprint requests: Seyit Temel Ceyhan, M.D., Department of Obstetrics and Gynecology, Gülhane Military Medical Academy, School of Medicine, 06018 Etlik, Ankara, Turkey (FAX: 90-312-3045800).
  • ,
  • Onder Onguru, M.D.

      Affiliations

    • Department of Pathology, Gulhane Military Medical Academy and Medical School, Etlik, Ankara, Turkey
  • ,
  • İskender Baser, M.D.

      Affiliations

    • Department of Obstetrics and Gynecology, Gulhane Military Medical Academy and Medical School, Etlik, Ankara, Turkey
  • ,
  • Omer Gunhan, D.D.

      Affiliations

    • Department of Pathology, Gulhane Military Medical Academy and Medical School, Etlik, Ankara, Turkey

Received 1 December 2006 ,Revised 5 July 2007 ,Accepted 5 July 2007.

References 

  1. Ranney B. Endometriosis: pathogenesis, symptoms, and findings. Clin Obstet Gynecol. 1980;23:865–874
  2. Abulafia O, Sherer DM. Angiogenesis of the endometrium. Obstet Gynecol. 1999;94:148–153
  3. Healy DL, Rogers PA, Hii L, Wingfield M. Angiogenesis: a new theory for endometriosis. Hum Reprod Update. 1998;4:736–740
  4. Smith WL, Garavito RM, De Witt DL. Prostaglandin endoperoxide H synthases (cyclooxygenases)-1 and -2. J Biol Chem. 1996;271:33157–33160
  5. Dubious RN, Abramson SB, Crofford L, Gupta RA, Simon LS, Van de Putte LBA, et al. Cyclooxygenase in biology and disease. FASEB J. 1998;12:1063–1073
  6. Kirkpatrick K, Ogunkolade W, Elkak A, Bustin S, Jenkins P, Ghilchik M, et al. The mRNA expression of cyclooxygenase-2 (COX-2) and vascular endothelial growth factor (VEGF) in human breast cancer. Curr Med Res Opin. 2002;18:237–241
  7. McLaren J. Vascular endothelial growth factor and endometriotic angiogenesis. Hum Reprod Update. 2000;6:45–55
  8. Matsuzaki S, Canis M, Darcha C, Dallel R, Okamura K, Mage G. Cyclooxygenase-2 selective inhibitor prevents implantation of eutopic endometrium to ectopic sites in rats. Fertil Steril. 2004;82:1609–1615
  9. Ota H, Igarashi S, Sasaki M, Tanaka T. Distribution of cyclooxygenase-2 in eutopic and ectopic endometrium in endometriosis and adenomyosis. Hum Reprod. 2001;16:561–566
  10. Chishima F, Hayakawa S, Sugita K, Kinukawa N, Aleemuzzaman S, Nemoto N, et al. Increased expression of cyclooxygenase-2 in local lesions of endometriosis patients. Am J Reprod Immunol. 2002;48:50–56
  11. Weidner N, Semple JP, Welch WR, Folkman J. Tumor angiogenesis and metastasis—correlation in invasive breast carcinoma. N Engl J Med. 1991;324:1–8
  12. Weidner N, Folkman J, Pozza F, Bevilacqua P, Allred EN, Moore DH, et al. Tumor angiogenesis: a new significant and independent prognostic indicator in early-stage breast carcinoma. J Natl Cancer Inst. 1992;84:1875–1887
  13. Hansen S, Grabau DA, Rose C, Bak M, Sørensen FB. Angiogenesis in breast cancer. A comparative study of the observer variability of methods for determining microvessel density. Lab Invest. 1998;78:1563–1573
  14. Donnez J, Smoes P, Gillerot S, Casanas-Roux F, Nisolle M. Vascular endothelial growth factor (VEGF) in endometriosis. Hum Reprod. 1998;13:1686–1690
  15. Nisolle M, Casanas-Roux F, Anaf V, Mine JM, Donnez J. Morphometric study of the stromal vascularization in peritoneal endometriosis. Fertil Steril. 1993;59:681–684
  16. Hii LL, Rogers PA. Endometrial vascular and glandular expression of integrin alpha(v)beta3 in women with and without endometriosis. Hum Reprod. 1998;13:1030–1035
  17. Kim SH, Choi YM, Chae HD, Kim KR, Kim CH, Kang BM. Increased expression of endoglin in the eutopic endometrium of women with endometriosis. Fertil Steril. 2001;76:918–922
  18. Goteri G, Lucarini G, Filosa A, Pierantoni A, Montik N, Biagini G, et al. Immunohistochemical analysis of vascular endothelial growth factor cellular expression in ovarian endometriomata. Fertil Steril. 2004;81:1528–1533
  19. Oosterlynck DJ, Meuleman C, Sobis H, Vandeputte M, Koninckx PR. Angiogenic activity of peritoneal fluid from women with endometriosis. Fertil Steril. 1993;59:778–782
  20. McLaren J, Prentice A, Charnock-Jones DS, Smith SK. Vascular endothelial growth factor (VEGF) concentrations are elevated in peritoneal fluid of women with endometriosis. Hum Reprod. 1996;11:220–223
  21. Tan XJ, Lang JH, Liu DY, Shen K, Leng JH, Zhu L. Expression of vascular endothelial growth factor and thrombospondin-1 mRNA in patients with endometriosis. Fertil Steril. 2002;78:148–153
  22. Kupker W, Schultze-Mosgau A, Diedrich K. Paracrine changes in the peritoneal environment of women with endometriosis. Hum Reprod Update. 1998;4:719–723
  23. Williams CS, Tsujii W, Reese J, Dey SK, DuBois RN. Host cyclooxygenase-2 modulates carcinoma growth. J Clin Invest. 2000;105:1589–1594
  24. Matsuzaki S, Canis M, Pouly JL, Wattiez A, Okamura K, Mage G. Cyclooxygenase-2 expression in deep endometriosis and matched eutopic endometrium. Fertil Steril. 2004;82:1309–1315
  25. Mihalich A, Reina M, Mangioni S, Ponti E, Alberti L, Vigano P, et al. Different basic fibroblast growth factor and fibroblast growth factor-antisense expression in eutopic endometrial stromal cells derived from women with and without endometriosis. J Clin Endocrinol Metab. 2003;88:2853–2859
  26. Brenner RM, Nayak NR, Slayden OD, Critchley HO, Kelly RW. Premenstrual and menstrual changes in the macaque and human endometrium: relevance to endometriosis. Ann NY Acad Sci. 2002;955:60–74
  27. Deguchi M, Ishiko O, Sumi T, Yoshida H, Yamamoto K, Ogita S. Expression of angiogenic factors in extrapelvic endometriosis. Oncol Rep. 2001;8:1317–1319
  28. Noble LS, Takayama K, Zeitoun KM, Putman JM, Johns DA, Hinshelwood MM, et al. Prostaglandin E2 stimulates aromatase expression in endometriosis-derived stromal cells. J Clin Endocrinol Metab. 1997;82:600–606
  29. Hull ML, Charnock-Jones DS, Chan CL, Bruner-Tran KL, Osteen KG, Tom BD, et al. Antiangiogenic agents are effective inhibitors of endometriosis. J Clin Endocrinol Metab. 2003;88:2889–2899
  30. Dogan E, Saygili U, Posaci C, Tuna B, Caliskan S, Altunyurt S, et al. Regression of endometrial explants in rats treated with the cyclooxygenase-2 inhibitor rofecoxib. Fertil Steril. 2004;82:1115–1120
  31. Laschke MW, Elitzsch A, Scheuer C, Vollmar B, Menger MD. Selective cyclo-oxygenase-2 inhibition induces regression of autologous endometrial grafts by down-regulation of vascular endothelial growth factor-mediated angiogenesis and stimulation of caspase-3-dependent apoptosis. Fertil Steril. 2007;87:163–171
  32. Fasciani A, D'Ambrogio G, Bocci G, Luisi S, Artini PG, Genazzani AR. Vascular endothelial growth factor and interleukin-8 in ovarian cystic pathology. Fertil Steril. 2001;75:1218–1221

PII: S0015-0282(07)02984-6

doi: 10.1016/j.fertnstert.2007.07.1332

Fertility and Sterility
Volume 90, Issue 4 , Pages 988-993 , October 2008