Fertility and Sterility
Volume 90, Issue 4 , Pages 1055-1063 , October 2008

Oral contraceptive pill pretreatment in ovarian stimulation with GnRH antagonists for IVF: a systematic review and meta-analysis

  • George Griesinger, M.D.

      Affiliations

    • Department of Obstetrics and Gynecology, University Clinic of Schleswig–Holstein, Campus Luebeck, Luebeck, Germany
    • Corresponding Author InformationReprint requests: George Griesinger, M.D., University Clinic of Schleswig–Holstein, Campus Luebeck, Department of Obstetrics and Gynecology, Ratzeburger Allee 160, 23538 Luebeck, Germany (FAX: +49 451 500 2170).
    • ,
  • Christos A. Venetis, M.D.

      Affiliations

    • Unit for Human Reproduction, 1st Department of Obstetrics and Gynaecology, Aristotle University of Thessaloniki, Thessaloniki, Greece
    • ,
  • Tanja Marx

      Affiliations

    • Department of Obstetrics and Gynecology, University Clinic of Schleswig–Holstein, Campus Luebeck, Luebeck, Germany
    • ,
  • Klaus Diedrich, M.D., Ph.D.

      Affiliations

    • Department of Obstetrics and Gynecology, University Clinic of Schleswig–Holstein, Campus Luebeck, Luebeck, Germany
    • ,
  • Basil C. Tarlatzis, M.D., Ph.D.

      Affiliations

    • Unit for Human Reproduction, 1st Department of Obstetrics and Gynaecology, Aristotle University of Thessaloniki, Thessaloniki, Greece
    • ,
  • Efstratios M. Kolibianakis, M.D., Ph.D.

      Affiliations

    • Unit for Human Reproduction, 1st Department of Obstetrics and Gynaecology, Aristotle University of Thessaloniki, Thessaloniki, Greece

Received 11 July 2007 ,Revised 23 July 2007 ,Accepted 23 July 2007.

References 

  1. Kolibianakis EM, Collins J, Tarlatzis B, Devroey P, Diedrich K, Griesinger G. Among patients treated for IVF with gonadotrophins and GnRH-analogues, is the probability of live birth dependent on the type of analogue used? A systematic review and meta-analysis. Hum Reprod Update. 2006;12:651–671
  2. Kolibianakis EM, Tarlatzis B, Devroey P. GnRH antagonists in IVF. Reprod Biomed Online. 2005;10:705–712
  3. Diedrich K, Diedrich C, Santos E, Zoll C, Al-Hasani S, Reissmann T, et al. Suppression of the endogenous luteinizing hormone surge by the gonadotrophin-releasing hormone antagonist Cetrorelix during ovarian stimulation. Hum Reprod. 1994;9:788–791
  4. Olivennes F, Alvarez S, Bouchard P, Fanchin R, Salat-Baroux J, Frydman R. The use of a GnRH antagonist (Cetrorelix) in a single dose protocol in IVF-embryo transfer: a dose finding study of 3 versus 2 mg. Hum Reprod. 1998;13:2411–2414
  5. Meldrum D, Scott R, Levy MJ, Alper M, Noyes N. A pilot study to assess oral contraceptive (OC) pre-treatment in women undergoing controlled ovarian hyperstimulation (COH) in ganirelix acetate cycles. Fertil Steril. 2002;78(Suppl 1):S176
  6. Fischl F, Huber JC, Obruca A. Zeitliche Optimierung der kontrollierten Hyperstimulation (KOH) in Kombination mit GnrH-Antagonisten und Ovulationshemmer in einem IVF-Programm. J Fertil Reprod. 2001;11:50–51
  7. Barmat LI, Chantilis SJ, Hurst BS, Dickey RP. A randomized prospective trial comparing gonadotropin-releasing hormone (GnRH) antagonist/recombinant follicle-stimulating hormone (rFSH) versus GnRH-agonist/rFSH in women pretreated with oral contraceptives before in vitro fertilization. Fertil Steril. 2005;83:321–330
  8. Bax L, Yu LM, Ikeda N, Tsuruta N, Moons KGM. MIX: comprehensive free software for meta-analysis of causal research data, Version 1,54. 2006. Available from Leon Bax, Department of Medical Informatics, Graduate School of Medical Sciences, Kitasato University, Kitasato 1-15-1, Sagamihara city, Kanagawa, 228-8555 Japan.
  9. Higgins JPT, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. BMJ. 2003;327:557–560
  10. Galera V, Verdu V, Villafanez E, Garijo J, Rayward J, Bajo JM. Comparison of plasmatic steroid levels with and without previous oral contraceptive administration in GnRH-antagonist IVF cycles. Hum Reprod. 2004;82(Suppl 2):S32
  11. Kim CH, Lee HA, Lee JW, Lee YJ, Nah HY, Hong SH, et al. The efficacy of oral contraceptive pretreatment in controlled ovarian hyperstimulation using a GnRH-antagonist protocol in low responders. Hum Reprod. 2005;20:i105
  12. Kolibianakis EM, Papanikolaou EG, Camus M, Tournaye H, Van Steirteghem AC, Devroey P. Effect of oral contraceptive pill pretreatment on ongoing pregnancy rates in patients stimulated with GnRH antagonists and recombinant FSH for IVF. A randomized controlled trial. Hum Reprod. 2006;21:352–357
  13. Huirne JA, van Loenen AC, Donnez J, Pirard C, Homburg R, Schats R, et al. Effect of an oral contraceptive pill on follicular development in IVF/ICSI patients receiving a GnRH antagonist: a randomized study. Reprod Biomed Online. 2006;13:235–245
  14. Rombauts L, Healy D, Norman RJ. Comparative randomized trial to assess the impact of oral contraceptive pretreatment on follicular growth and hormone profi les in GnRH antagonist-treated patients. Hum Reprod. 2006;21:95–103
  15. Cédrin-Durnerin I, Bständig B, Parneix I, Bied-Damon V, Avril C, Decanter C, et al. Effects of oral contraceptive, synthetic progestogen or natural estrogen pre-treatments on the hormonal profile and the antral follicle cohort before GnRH antagonist protocol. Hum Reprod [Advance access August 26, 2006, doi:10.1093/humrep/del340].
  16. Griesinger G, Felberbaum R, Diedrich K. GnRH antagonists in ovarian stimulation: a treatment regimen of clinicians' second choice? Data from the German national IVF registry. Hum Reprod. 2005;20:2373–2375

 Financial support: none.

 E.M. Kolibianakis and B.C. Tarlatzis are author and coauthor of one of the randomized controlled trials included in this review.

PII: S0015-0282(07)03007-5

doi: 10.1016/j.fertnstert.2007.07.1354

Fertility and Sterility
Volume 90, Issue 4 , Pages 1055-1063 , October 2008

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