Fertility and Sterility
Volume 90, Issue 4 , Pages 1155-1160 , October 2008

Association of the protein Z intron F G79A gene polymorphism with recurrent pregnancy loss

  • Astrid Dossenbach-Glaninger, M.D.

      Affiliations

    • Department of Laboratory Medicine, Rudolfstiftung Hospital, Vienna, Austria
    • ,
  • Michael van Trotsenburg, M.D.

      Affiliations

    • Division of Gynecologic Endocrinology and Reproductive Medicine, Medical University of Vienna, Vienna, Austria
    • ,
  • Hanns Helmer, M.D.

      Affiliations

    • Division of Obstetrics and Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Medical University of Vienna, Vienna, Austria
    • ,
  • Christian Oberkanins, Ph.D.

      Affiliations

    • ViennaLab Diagnostics, Vienna, Austria
    • ,
  • Pierre Hopmeier, M.D.

      Affiliations

    • Department of Laboratory Medicine, Rudolfstiftung Hospital, Vienna, Austria
    • Corresponding Author InformationReprint requests: Pierre Hopmeier, M.D., Department of Laboratory Medicine, Rudolfstiftung Hospital, Juchgasse 25, A-1030 Vienna, Austria (FAX: +43 1 71165 3309).

Received 20 June 2007 ,Revised 25 July 2007 ,Accepted 25 July 2007.

References 

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  9. Dossenbach-Glaninger A, van Trotsenburg M, Dossenbach MR, Oberkanins C, Moritz A, Krugluger W, et al. Plasminogen activator inhibitor-1 4G/5G polymorphism and coagulation factor XIII Val34Leu polymorphism: impaired fibrinolysis and early pregnancy loss. Clin Chem. 2003;49:1081–1086
  10. Buchholz T, Lohse P, Rogenhofer N, Kosian E, Pihusch R, Thaler CJ. Polymorphisms in the ACE and PAI-1 genes are associated with recurrent spontaneous miscarriages. Hum Reprod. 2003;18:2473–2477
  11. Goodman CS, Coulam CB, Jeyendram RS, Acosta VA, Roussev R. Which thrombophilic gene mutations are risk factors for recurrent pregnancy loss?. Am J Reprod Immunol. 2006;56:230–236
  12. Fatini C, Genuini F, Bavaglini B, Prisco D, Fedi S, Marcucci R, et al. Angiotensin-converting enzyme DD genotype, angiotensin type 1 receptor CC genotype, and hyperhomocysteinemia increase first-trimester fetal-loss susceptibility. Blood Coagul Fibrinolysis. 2000;11:657–662
  13. Gris JC, Quere I, Dechaud H, Mercier E, Pincon C, Hoffet M, et al. High frequency of protein Z deficiency in patients with unexplained early fetal loss. Blood. 2002;99:2606–2608
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  15. Paidas MJ, Ku DH, Lee MJ, Manish S, Thurston A, Lockwood CJ, et al. Protein Z, protein S levels are lower in patients with thrombophilia and subsequent pregnancy complications. J Thromb Haemost. 2005;3:497–501
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  19. Lichy C, Kropp S, Dong-Si T, Genius J, Dolan T, Hampe T, et al. A common polymorphism of the protein Z gene is associated with protein Z plasma levels and with risk of cerebral ischemia in the young. Stroke. 2004;35:40–45
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  24. Dossenbach-Glaninger A, van Trotsenburg M, Dossenbach MR, Oberkanins C, Moritz A, Krugluger W, et al. Elevated coagulation factor VIII and the risk for recurrent early pregnancy loss. Thromb Haemost. 2004;91:694–699
  25. Lichy C, Dong-Si T, Reuner K, Genius J, Rickmann H, Hampe T, et al. Risk of cerebral venous thrombosis and novel gene polymorphisms of the coagulation and fibrinolytic systems. J Neurol. 2006;253:316–320
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 Supported by Roche Diagnostics, Mannheim, Germany.

 Presented at the 6th International Symposium on Molecular Diagnostics in Laboratory Medicine and 3rd International Symposium on Gene Therapy, May 25–27, 2006, Graz, Austria.

 Dr. Oberkanins is an employee of ViennaLab Diagnostics.

PII: S0015-0282(07)03021-X

doi: 10.1016/j.fertnstert.2007.07.1376

Fertility and Sterility
Volume 90, Issue 4 , Pages 1155-1160 , October 2008

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