Fertility and Sterility
Volume 90, Issue 2 , Pages 391-394 , August 2008

The effect of interleukin-6 on ciliary beat frequency in the human fallopian tube

  • A. Papathanasiou, M.R.C.O.G.
  • ,
  • O. Djahanbakhch, F.R.C.O.G., M.D.

      Affiliations

    • Corresponding Author InformationReprint requests: Professor O. Djahanbakhch, Department of Obstetrics and Gynaecology, Fourth Floor, Holland Wing, The Royal London Hospital, Whitechapel, London E1 2BB, UK (FAX: 00442073638775).
  • ,
  • E. Saridogan, Ph.D., M.R.C.O.G.
  • ,
  • R.A. Lyons, M.R.C.O.G.

Received 12 May 2007 ,Revised 25 July 2007 ,Accepted 25 July 2007.

References 

  1. Lyons RA, Saridogan E, Djahanbakhch O. The reproductive significance of human fallopian tube cilia. Hum Reprod Update. 2006;12:363–372
  2. Halbert SA, Tam PY, Blandau RJ. Egg transport in the rabbit oviduct: the roles of cilia and muscle. Science. 1976;191:1052–1053
  3. Halbert SA, Patton DL, Zarutskie PW, Soules MR. Function and structure of cilia in the fallopian tube on an infertile woman with Kartagener's syndrome. Hum Reprod. 1997;12:55–58
  4. Verdugo P. Ca2+-dependent hormonal stimulation of ciliary activity. Nature. 1980;283:764–765
  5. Villalon M, Cardina-Danovaro M. ATP increase the frequency of ciliary beat of human oviductal ciliated cells. Biol Reprod. 1994;50(Suppl):139
  6. Verdugo P, Rumery RE, Tam PY. Hormonal control of oviductal ciliary activity: effect of prostaglandins. Fertil Steril. 1980;33:193–196
  7. Villalon M, Verdugo P. Hormonal regulation of ciliary function in the oviduct: the effect of beta-adrenergic agonists. Prog Clin Biol Res. 1982;80:59–65
  8. Saridogan E, Djahanbakhch O, Puddefoot JR, Demetroulis C, Mehta JG, Colingwood K, et al. Angiotensin II receptors and angiotensin II stimulation of ciliary activity in human fallopian tube. J Clin Endocrinol Metab. 1996;81:2719–2725
  9. Mahmood T, Saridogan E, Smutna S, Habib AM, Djahanbakhch O. The effect of ovarian steroids on epithelial ciliary beat frequency in the human fallopian tube. Hum Reprod. 1998;13:2991–2994
  10. Lyons RA, Djahanbakhch O, Mahmood T, Saridogan E, Sattar S, Sheaff MT, et al. Fallopian tube ciliary beat frequency in relation to stage of menstrual cycle and anatomical site. Hum Reprod. 2002;17:584–588
  11. Mahnke JL, Dawood MY, Huang JC. Vascular endothelial growth factor and interleukin-6 in peritoneal fluid in women with endometriosis. Fertil Steril. 2000;73:166–170
  12. Keenan JA, Chen TT, Chadwell NL, Torry DS, Caudle MR. Interferon-gamma (IFN-gamma) and interleukin-6 (IL-6) in peritoneal fluid and macrophage-conditioned media of women with endometriosis. Am J Reprod Immunol. 1994;32:180–183
  13. Lyons RA, Djahanbakhch O, Saridogan E, Naftalin AA, Mahmood T, Weekes A, et al. Peritoneal fluid, endometriosis and ciliary beat frequency in the human fallopian tube. Lancet. 2002;360:1221–1222
  14. Punnonen J, Teisala K, Ranta H, Bennett B, Punnonen R. Increased levels of interleukin-6 and interleukin-10 in the peritoneal fluid of women with endometriosis. Am J Obstet Gynecol. 1996;174:1522–1526
  15. Wu MY, Ho HN, Chen SU, Chao KH, Chen CD, Yang YS. Increase in the production of interleukin-6, interleukin-10, and interleukin-12 by lipopolysaccharide-stimulated peritoneal macrophages from women with endometriosis. Am J Reprod Immunol. 1999;41:106–111
  16. Tsudo T, Harada T, Iwabe T, Tanikawa M, Nagano Y, Ito M, et al. Altered gene expression and secretion of interleukin-6 in stromal cells derived from endometriotic tissues. Fertil Steril. 2000;73:205–211
  17. Bergqvist A, Bruce C, Carlberg M, Carlstrom K. Interleukin-1beta, interleukin-6, and tumor necrosis factor-alpha in endometriotic tissue and in endometrium. Fertil Steril. 2001;75:489–495
  18. Gabay C. Interleukin-6 and chronic inflammation. Arthritis Res Ther. 2006;8(Suppl 2):S3
  19. Rose-John S, Scheller J, Elson G, Jones SA. Interleukin-6 biology is coordinated by membrane-bound and soluble receptors: role in inflammation and cancer. J Leukoc Biol. 2006;80:227–236
  20. Maisey K, Nardocci G, Imarai M, Cardenas H, Rios M, Croxatto HB, et al. Expression of proinflammatory cytokines and receptors by human fallopian tubes in organ culture following challenge with Neisseria gonorrheae. Infect Immun. 2003;71:527–532
  21. Harada T, Yoshioka H, Yoshida S, Iwabe T, Onohara Y, Tanikawa M, et al. Increased interleukin-6 levels in peritoneal fluid of infertile patients with active endometriosis. Am J Obstet Gynecol. 1997;176:593–597
  22. Liu Y, Luo L, Zhao H. Changes of cytokines levels in peritoneal fluid of patients with endometriosis and its effect on reproductive activity. J Tongji Med Univ. 2000;20:163–165
  23. Yoshida S, Harada T, Iwabe T, Taniguchi F, Mitsunari M, Yamauchi N, et al. A combination of interleukin-6 and its soluble receptor impairs sperm motility: implications in infertility associated with endometriosis. Hum Reprod. 2004;19:1821–1825
  24. Gomez-Torres MJ, Acien P, Campos A, Velasco I. Embryotoxicity of peritoneal fluid in women with endometriosis. Its relation with cytokines and lymphocyte populations. Hum Reprod. 2002;17:777–781
  25. Rier SE, Parsons AK, Becker JL. Altered interleukin-6 production by peritoneal leukocytes from patients with endometriosis. Fertil Steril. 1994;61:294–299

 Dr. Saridogan has received honoraria for research and teaching from Ethicon Endosurgery and Women's Health.

PII: S0015-0282(07)03024-5

doi: 10.1016/j.fertnstert.2007.07.1379

Fertility and Sterility
Volume 90, Issue 2 , Pages 391-394 , August 2008