Effect of metformin pretreatment on pregnancy outcome of in vitro matured oocytes retrieved from women with polycystic ovary syndrome
Received 14 February 2007; received in revised form 27 July 2007 published online 19 November 2007.
Objective
To determine the effect of metformin pretreatment on in vitro maturation (IVM) in the patients with clomiphene citrate-resistant polycystic ovary syndrome.
Design
Prospective randomized study.
Setting
University affiliated hospital.
Patient(s)
Fifty-six women with clomiphene citrate-resistant polycystic ovary syndrome underwent 70 cycles of IVM treatment.
Intervention(s)
Metformin was administered at a dose of 500 mg twice per day for 12 weeks before IVM treatment.
Main Outcome Measure(s)
The number of immature oocytes, oocyte maturation, fertilization, cleavage, high-quality embryo, and clinical pregnancy rates.
Result(s)
A significantly higher high-quality embryo rate (37.8%) was obtained in the metformin-treated group compared with the control group (24.3%). Accordingly, the clinical pregnancy and implantation rates were significantly higher in the metformin-treated group (38.2% and 15.3%) than the control group (16.7% and 6.2%).
Conclusion(s)
Pretreatment with metformin improves IVM outcome in terms of embryo quality and clinical pregnancy rate as well as implantation rate.
aReproductive Medicine Center, The First Affiliated Hospital, Anhui Medical University, Hefei, People's Republic of China
bPharmacological College, Anhui Medical University, Hefei, People's Republic of China
Reprint requests to: Yunxia Cao, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, People's Republic of China (FAX: 86 511 2923 241)
Jun Li, Pharmacological College, Anhui Medical University, Hefei, 230032, People's Republic of China. (FAX: 86 511 5161 115).
There was no conflict of interest with any product used in this study.
ABSTRACT