Fertility and Sterility
Volume 90, Issue 4 , Pages 1149-1154 , October 2008

Effect of metformin pretreatment on pregnancy outcome of in vitro matured oocytes retrieved from women with polycystic ovary syndrome

  • Zhaolian Wei, M.D.

      Affiliations

    • Reproductive Medicine Center, The First Affiliated Hospital, Anhui Medical University, Hefei, People's Republic of China
    • ,
  • Yunxia Cao, M.D., Ph.D.

      Affiliations

    • Reproductive Medicine Center, The First Affiliated Hospital, Anhui Medical University, Hefei, People's Republic of China
    • Corresponding Author InformationReprint requests to: Yunxia Cao, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, People's Republic of China (FAX: 86 511 2923 241)
    • ,
  • Lin Cong, M.D.

      Affiliations

    • Reproductive Medicine Center, The First Affiliated Hospital, Anhui Medical University, Hefei, People's Republic of China
    • ,
  • Ping Zhou, M.D.

      Affiliations

    • Reproductive Medicine Center, The First Affiliated Hospital, Anhui Medical University, Hefei, People's Republic of China
    • ,
  • Zhiguo Zhang, MSc.

      Affiliations

    • Reproductive Medicine Center, The First Affiliated Hospital, Anhui Medical University, Hefei, People's Republic of China
    • ,
  • Jun Li, Ph.D.

      Affiliations

    • Pharmacological College, Anhui Medical University, Hefei, People's Republic of China
    • Corresponding Author InformationJun Li, Pharmacological College, Anhui Medical University, Hefei, 230032, People's Republic of China. (FAX: 86 511 5161 115).

Received 14 February 2007 ,Revised 27 July 2007

References 

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  3. Poloson DW, Kiddy DS, Mason HD, Franks S. Induction of ovulation with clomiphene citrate in women with polycystic ovary syndrome: the difference between responders and nonresponders. Fertil Steril. 1989;51:30–34
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  9. Velazquez EM, Mendoza SG, Hamer T, Sosa F, Glueck CJ. Metformin therapy in Polycystic ovary syndrome reduces hyperinsulinemia, insulin resistance, hyperandrogenaemia, and systolic blood pressure while facilitating normal menses and pregnancy. Metab Clin Exp. 1994;43:647–654
  10. Genazzani AD, Battaglia C, Malavasi B, Strucchi C, Tortolani F, Gamba O. Metformin administration modulates and restores luteinizing hormone spontaneous episodic secretion and ovarian function in nonobese patients with polycystic ovary syndrome. Fertil Steril. 2004;81:114–119
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  16. Stadtmauer LA, Toma SK, Riehl RM, Talbert LM. Metformin treatment of patients with polycystic ovary syndrome undergoing in vitro fertilization improves outcomes and is associated with modulation of the insulin-like growth facth factor. Fertil Steril. 2001;75:505–509
  17. Genazzani AD, Lanzoni C, Ricchieri F, Baraldi E, Casarosa E, Jasonni VM. Metformin administration is more effective when non-obese patients with polycystic ovary syndrome show both hyperandrogenism and hyperinsulinemia. Gynecol Endocrinol. 2007;23:146–152
  18. Tang T, Glanville J, Orsi N, Barth JH, Balen AH. The use of metformin for women with PCOS undergoing IVF treatment. Hum Reprod. 2006;21:1416–1425
  19. Khattab S, Fotouh IA, Mohesn IA, Metwally M, Moaz M. Use of metformin for prevention of ovarian hyperstimulation syndrome: a novel approach. Reprod Biomed Online. 2006;13:194–197
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  21. Trounson A, Wood C, Kausche A. In vitro maturation and the fertilization and developmental competence of oocytes recovered from untreated polycystic ovarian patients. Fertil Steril. 1994;62:353–362
  22. Child TJ, Phillips SJ, Abdul-Jalil AK, Gulekli B, Tan SL. A comparison of in vitro maturation and in vitro fertilization for woman with polycystic ovaries. Obstet Gynecol. 2002;100:665–670
  23. Mikkelsen AL, Lindenberg S. Benefit of priming women with PCOS to the in vitro maturation procedure and outcome: a randomized prospective study. Reproduction. 2001;122:587–592
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 There was no conflict of interest with any product used in this study.

PII: S0015-0282(07)03042-7

doi: 10.1016/j.fertnstert.2007.07.1385

Fertility and Sterility
Volume 90, Issue 4 , Pages 1149-1154 , October 2008

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