Fertility and Sterility
Volume 88, Issue 4 , Pages 781-784 , October 2007

Substandard application of preimplantation genetic screening may interfere with its clinical success

  • Santiago Munné, Ph.D.

      Affiliations

    • Reprogenetics, Livingston, New Jersey
    • Corresponding Author InformationReprint requests: Santiago Munné, Ph.D., Reprogenetics, 3 Regent Street, Suite 301, Livingston, New Jersey 07039 (FAX: 973-992-1423).
    • ,
  • Luca Gianaroli, M.D.

      Affiliations

    • S.I.S.Me.R., Bologna, Italy
    • ,
  • Ilan Tur-Kaspa, M.D.

      Affiliations

    • Reproductive Genetics Institute, Chicago, Illinois
    • ,
  • Cristina Magli, Ph.D.

      Affiliations

    • S.I.S.Me.R., Bologna, Italy
    • ,
  • Mireia Sandalinas, M.Sc.

      Affiliations

    • Reprogenetics-Spain, Barcelona, Spain
    • ,
  • Jamie Grifo, M.D.

      Affiliations

    • New York University, New York, New York
    • ,
  • David Cram, Ph.D.

      Affiliations

    • Monash IVF, Clayton, Victoria, Australia
    • ,
  • Semra Kahraman, M.D.

      Affiliations

    • Istanbul Memorial Hospital, Istanbul, Turkey
    • ,
  • Yury Verlinsky, Ph.D.

      Affiliations

    • Reproductive Genetics Institute, Chicago, Illinois
    • ,
  • Joe L. Simpson, M.D.

      Affiliations

    • Florida International University College of Medicine, Miami, Florida

Received 29 July 2007 ,Revised 3 August 2007 ,Accepted 3 August 2007.

References 

  1. Abdalla HI, Wren ME, Thomas A, Korea L. Age of the uterus does not affect pregnancy or implantation rates; a study of egg donation in women of different ages sharing oocytes from the same donor. Hum Reprod. 1997;12:827–829
  2. Munné S, Serena C, Colls P, Garrisi J, Zheng X, Cekleniak N, et al. Maternal age, morphology, development and chromosome abnormalities in over 6000 cleavage-stage embryos. Reprod Biomed Online. 2007;14:628–634
  3. Magli MC, Gianaroli L, Ferrareti AP, Lappi M, Ruberti A, Farfalli V. Embryo morphology and development are dependent on the chromosome complement. Fertil Steril. 2007;87:534–541
  4. Munné S, Lee A, Rosenwaks Z, Grifo J, Cohen J. Diagnosis of major chromosome aneuploidies in human preimplantation embryos. Hum Reprod. 1993;8:2185–2191
  5. Verlinsky Y, Cohen J, Munne S, Gianaroli L, Simpson JL, Ferraretti AP, et al. Over a decade of preimplantation genetic diagnosis experience—a multicenter report. Fertil Steril. 2004;82:292–294
  6. Munné S, Magli C, Cohen J, Morton P, Sadowy S, Gianaroli L, et al. Positive outcome after preimplantation diagnosis of aneuploidy in human embryos. Hum Reprod. 1999;14:2191–2199
  7. Gianaroli L, Magli C, Ferraretti AP, Munné S. Preimplantation diagnosis for aneuploidies in patients undergoing in-vitro fertilization with a poor prognosis: identification of the categories for which it should be proposed. Fertil Steril. 1999;72:837–844
  8. Munné S, Sandalinas M, Escudero T, Velilla E, Walmsley R, Sadowy S, et al. Improved implantation after preimplantation genetic diagnosis of aneuploidy. Reprod Biomed Online. 2003;7:91–97
  9. Munné S, Fischer J, Warner A, Chen S, Zouves C, Cohen J, et al. Preimplantation genetic diagnosis significantly reduces pregnancy loss in infertile couples: a multi-center study. Fertil Steril. 2006;85:326–332
  10. Verlinsky Y, Tur-Kaspa I, Cieslak J, Bernal A, Morris R, Taranissi M, et al. Preimplantation testing for chromosomal disorders improves reproductive outcome of poor prognosis patients. Reprod Biomed Online. 2005;11:219–225
  11. Colls P, Escudero T, Cekleniak N, Sadowy S, Cohen J, Munne S. Increased efficiency of preimplantation genetic diagnosis for infertility using “no result rescue.”. Fertil Steril. 2007;88:53–61
  12. Staessen C, Platteau P, Van Assche E, Michiels A, Tournaye H, Camus M, et al. Comparison of blastocyst transfer with or without preimplantation genetic diagnosis for aneuploidy screening in couples with advanced maternal age: a prospective randomized controlled trial. Hum Reprod. 2004;19:2849–2858
  13. Mastenbroek S, Twisk M, Van Echten-arends J, Sikkema-Raddatz B, Korevaar JC, Verhoeve HR, et al. Preimplantation genetic screening in women of advanced maternal age. N Engl J Med. 2007;357:9–17
  14. Cieslak-Janzen J, Tur-Kaspa I, Ilkevitch Y, Bernal A, Morris R, Verlinsky Y. Multiple micromanipulations for PGD does not affect embryo development to blastocyst. Fertil Steril. 2006;85:1826–1829
  15. Donoso P, Verpoest W, Papanikolaou EG, Liebaers I, Fatemi HM, Sermon K, et al. Single embryo transfer in preimplantation genetic diagnosis cycles for women <36 years does not reduce delivery rate. Hum Reprod. 2007;22:1021–1025
  16. Magli C, Gianaroli L, Ferraretti AP, Toschi M, Esposito F, Fasolino MC. The combination of polar body and embryo biopsy does not affect embryo viability. Hum Reprod. 2004;19:1163–1169
  17. Cohen J, Wells D, Munné S. Removal of two cells from cleavage stage embryos is likely to reduce the efficacy of chromosomal tests employed to enhance implantation rates. Fertil Steril. 2007;87:496–503
  18. Edgar DH, Bourne H, Jericho H, McBain JC. The developmental potential of cryopreserved human embryos. Mol Cell Endocrinol. 2000;27:169:69–72
  19. Li L, Munné S, Licciardi F, Noev Y, Tadik Y, Godke R, et al. Effect of UV laser on the development of mouse embryos assessed by microinjection of FITC-Dextran. Zygote. 1993;1:43–48
  20. Velilla E, Escudero T, Munne S. Blastomere fixation techniques and risk of misdiagnosis for preimplantation genetic diagnosis of aneuploidy. Reprod Biomed Online. 2002;4:210–217
  21. Munné S, Bahçe M, Sandalinas M, Escudero T, Márquez C, Velilla E, et al. Differences in chromosome susceptibility to aneuploidy and survival to first trimester. Reprod Biomed Online. 2004;8:81–90
  22. Simpson JL. Incidence and timing of pregnancy losses: relevance to evaluating safety of early prenatal diagnosis. Am J Med Genet. 1990;35:165–173
  23. Baart E, Van Opstal D, Los FJ, Fauser BCJM, Martini E. Fluorescence in situ hybridization analysis of two blastomeres from day 3 frozen-thawed embryos followed by analysis of the remaining embryo on day 5. Hum Reprod. 2004;19:685–693

 S.M. is Director of Reprogenetics, a laboratory specializing in preimplantation genetic diagnosis. I.T.-K. has received research funding from Serono and is on the speaker's bureau for Organon. M.S. has a financial interest in Reprogenetics. Y.V. is owner and chief executive officer of Reproductive Genetics Institute, which operates clinics that provide preimplantation genetic diagnosis. J.L.S. is a member of the medical advisory board for Biocept and is a member of the scientific advisory board for IMETRIKUS.

PII: S0015-0282(07)03052-X

doi: 10.1016/j.fertnstert.2007.08.002

Fertility and Sterility
Volume 88, Issue 4 , Pages 781-784 , October 2007

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