Fertility and Sterility
Volume 90, Issue 5 , Pages 1685-1691 , November 2008

Low-dose acetylsalicylic acid plus prednisolone as an adjuvant treatment in IVF: a prospective, randomized study

  • Alberto Revelli, M.D., Ph.D.

      Affiliations

    • Reproductive Medicine and IVF Unit, Department of Obstetrical and Gynecological Sciences, S. Anna Hospital, University of Turin, Turin, Italy
    • Corresponding Author InformationReprint requests: Alberto Revelli, M.D., Reproductive Medicine and IVF Unit, Department of Obstetrical and Gynecological Sciences, S. Anna Hospital, University of Turin, Via Ventimiglia 3, 10126, Torino, Italy (FAX: 390116964022).
    • ,
  • Elisabetta Dolfin, M.D.

      Affiliations

    • Reproductive Medicine and IVF Unit, Department of Obstetrical and Gynecological Sciences, S. Anna Hospital, University of Turin, Turin, Italy
    • ,
  • Gianluca Gennarelli, M.D., Ph.D.

      Affiliations

    • Reproductive Medicine and IVF Unit, Department of Obstetrical and Gynecological Sciences, S. Anna Hospital, University of Turin, Turin, Italy
    • ,
  • Teresa Lantieri, M.D.

      Affiliations

    • Reproductive Medicine and IVF Unit, Department of Obstetrical and Gynecological Sciences, S. Anna Hospital, University of Turin, Turin, Italy
    • ,
  • Marco Massobrio, M.D.

      Affiliations

    • Reproductive Medicine and IVF Unit, Department of Obstetrical and Gynecological Sciences, S. Anna Hospital, University of Turin, Turin, Italy
    • ,
  • Jan Gunnar Holte, M.D., Ph.D.

      Affiliations

    • Carl von Linné Kliniken, Uppsala, Sweden
    • ,
  • Ilan Tur-Kaspa, M.D.

      Affiliations

    • Institute for Human Reproduction and Reproductive Genetics Institute, Chicago, Illinois

Received 19 April 2007 ,Revised 14 August 2007 ,Accepted 14 August 2007.

References 

  1. Clarke RJ, Mayo G, Price P, Fitzgerald GA. Suppression of thromboxane A2 but not of systemic prostacyclin by controlled-release aspirin. N Engl J Med. 1991;325:1137–1141
  2. Rai R, Backos M, Baxter N, Chilcott I, Regan L. Recurrent miscarriage—an aspirin a day?. Hum Reprod. 2000;15:2220–2223
  3. Wada I, Hsu CC, Williams G, Macnamee MC, Brinsden PR. The benefits of low-dose aspirin therapy in women with impaired uterine perfusion during assisted conception. Hum Reprod. 1994;9:1954–1957
  4. Kutteh WH, Yetman DL, Chantilis SJ, Crain J. Effect of antiphospholipid antibodies in women undergoing in-vitro fertilization: role of heparin and aspirin. Hum Reprod. 1997;12:1171–1175
  5. Rubinstein M, Marazzi A, Polak de Fried E. Low-dose aspirin treatment improves ovarian responsiveness, uterine and ovarian blood flow velocity, implantation, and pregnancy rates in patients undergoing in vitro fertilization: a prospective, randomized, double-blind placebo-controlled study. Fertil Steril. 1999;71:825–829
  6. Lok IH, Yip SK, Cheung LP, Yin Leung PH, Haines CJ. Adjuvant low-dose aspirin therapy in poor responders undergoing in vitro fertilization: a prospective, randomized, double-blind, placebo-controlled trial. Fertil Steril. 2004;81:556–561
  7. Pakkila M, Rasanen J, Heinonen S, Tinkanen H, Tuomivara L, Makikallio K, et al. Low-dose aspirin does not improve ovarian responsiveness or pregnancy rate in IVF and ICSI patients: a randomized, placebo-controlled double-blind study. Hum Reprod. 2005;20:2211–2214
  8. Waldenstrom U, Hellberg D, Nilsson S. Low-dose aspirin in a short regimen as standard treatment in in vitro fertilization: a randomized, prospective study. Fertil Steril. 2004;81:1560–1564
  9. Urman B, Mercan R, Alatas C, Balaban B, Isiklar A, Nuhoglu A. Low-dose aspirin does not increase implantation rates in patients undergoing intracytoplasmic sperm injection: a prospective randomized study. J Assist Reprod Genet. 2000;17:586–590
  10. Polak de Fried E, Blanco L, Lancuba S, Asch RH. Improvement of clinical pregnancy rate and implantation rate of in-vitro fertilization-embryo transfer patients by using methylprednisone. Hum Reprod. 1993;8:393–395
  11. Taniguchi F. Results of prednisolone given to improve the outcome of in vitro fertilization-embryo transfer in women with antinuclear antibodies. J Reprod Med. 2005;50:383–388
  12. Hasegawa I, Yamanoto Y, Suzuki M, Murakawa H, Kurabayashi T, Takikuwa K, et al. Prednisolone plus low-dose aspirin improves the implantation rate in women with autoimmune conditions who are undergoing in vitro fertilization. Fertil Steril. 1998;70:1044–1048
  13. Geva E, Amit A, Lerner-Geva L, Yaron Y, Daniel Y, Schwartz T, et al. Prednisone and aspirin improve pregnancy rate in patients with reproductive failure and autoimmune antibodies: a prospective study. Am J Reprod Immunol. 2000;43:36–40
  14. Ledee-Bataille N, Doumerc S, Olivennes F, Kadoch J, Chaouat G, Frydman R. Contribution of diagnostic ultrasonography in cases of repeated embryonic implantation failure in fertilization in vitro. J Gynecol Obstet Biol Reprod. 2001;30:747–752
  15. Tempfer CB, Kurz C, Bentz EK, Unfried G, Walch K, Czizek U, et al. A combination treatment of prednisone, aspirin, folate, and progesterone in women with idiopathic recurrent miscarriage: a matched-pair study. Fertil Steril. 2006;86:145–148
  16. Ubaldi F, Rienzi L, Ferrero S, Anniballo R, Iacobelli M, Cobellis L, et al. Low dose prednisolone administration in routine ICSI patients does not improve pregnancy and implantation rates. Hum Reprod. 2002;17:1544–1547
  17. Schild RL, Knobloch C, Dorn C, Fimmers R, Van der Ven H, Hansmann M. Endometrial receptivity in an in vitro fertilization program as assessed by spiral artery blood flow, endometrial thickness, endometrial volume, and uterine artery blood flow. Fertil Steril. 2001;75:361–366
  18. Keay SD, Harlow CR, Wood P, Jenkins JM, Cahill DJ. Higher cortisol:cortisone ratios in the preovulatory follicle of completely unstimulated IVF cycles indicate oocytes with increased pregnancy potential. Hum Reprod. 2002;17:2410–2414
  19. Michael AE, Collins TD, Norgate DP, Gregory L, Wood PJ, Cooke BA. Relationship between ovarian cortisol:cortisone ratios and the clinical outcome of in vitro fertilization and embryo transfer (IVF-ET). Clin Endocrinol. 1999;51:535–540
  20. Baruffi RLR, Contart P, Mauri AL, Petersen C, Felipe V, Garbellini E, et al. A uterine ultrasonographic scoring system as a method for the prognosis of embryo implantation. J Assist Reprod Genet. 2002;19:99–102
  21. Puerto B, Creus M, Carmona F, Civico S, Vanrell JA, Balasch J. Ultrasonography as a predictor of embryo implantation after in vitro fertilization: a controlled study. Fertil Steril. 2003;79:1015–1022
  22. Tummon I, Gavrilova-Jordan L, Allemand MC, Session D. Polycystic ovaries and ovarian hyperstimulation syndrome: a systematic review. Acta Obstet Gynecol Scand. 2005;84:611–616
  23. Almagor M, Hazav A, Yaffe H. The levels of C-reactive protein in women treated by IVF. Hum Reprod. 2004;19:104–106
  24. Orvieto R. Controlled ovarian hyperstimulation. J Soc Gynecol Invest. 2004;11:424–426

PII: S0015-0282(07)03219-0

doi: 10.1016/j.fertnstert.2007.08.037

Fertility and Sterility
Volume 90, Issue 5 , Pages 1685-1691 , November 2008

Article Tools