Fertility and Sterility
Volume 90, Issue 5 , Pages 1818-1825 , November 2008

Effect of letrozole at 2.5 mg or 5.0 mg/day on ovarian stimulation with gonadotropins in women undergoing intrauterine insemination

  • Luis Noriega-Portella, M.D.

      Affiliations

    • PRANOR, group of Assisted Reproduction, Universidad Peruana Cayetano Heredia, Lima, Peru
    • ,
  • Luis Noriega-Hoces, M.D.

      Affiliations

    • PRANOR, group of Assisted Reproduction, Universidad Peruana Cayetano Heredia, Lima, Peru
    • ,
  • Andrea Delgado, M.D.

      Affiliations

    • PRANOR, group of Assisted Reproduction, Universidad Peruana Cayetano Heredia, Lima, Peru
    • ,
  • Julio Rubio, Lic.

      Affiliations

    • Laboratory of Investigation and Development, Faculty of Sciences and Philosophy “Alberto Cazorla Talleri,” Universidad Peruana Cayetano Heredia, Lima, Peru
    • ,
  • Cynthia Gonzales-Castañeda, Lic.

      Affiliations

    • Laboratory of Investigation and Development, Faculty of Sciences and Philosophy “Alberto Cazorla Talleri,” Universidad Peruana Cayetano Heredia, Lima, Peru
    • ,
  • Gustavo F. Gonzales, M.D., D.Sc.

      Affiliations

    • Laboratory of Investigation and Development, Faculty of Sciences and Philosophy “Alberto Cazorla Talleri,” Universidad Peruana Cayetano Heredia, Lima, Peru
    • Corresponding Author InformationReprint requests: Gustavo F. Gonzales, MD, D.Sc., Av. Honorio Delgado 430, Lima, Peru (FAX: 00511-4821195).

Received 20 May 2007 ,Revised 28 August 2007 ,Accepted 28 August 2007.

References 

  1. Hong Y, Chen S. Aromatase inhibitors: structural features and biochemical characterization. Ann NY Acad Sci. 2006;1089:237–251
  2. Dunkel L. Use of aromatase inhibitors to increase final height. Mol Cell Endocrinol. 2006;254–5:207–216
  3. Holzer H, Casper R, Tulandi T. A new era in ovulation induction. Fertil Steril. 2006;85:277–284
  4. Mitwally MF, Biljan MM, Casper RF. Pregnancy outcome after the use of an aromatase inhibitor for ovarian stimulation. Am J Obstet Gynecol. 2005;192:381–386
  5. Bayar U, Basaran M, Kiran S, Coskun A, Gezer S. Use of an aromatase inhibitor in patients with polycystic ovary syndrome: a prospective randomized trial. Fertil Steril. 2006;86:1447–1451
  6. Begun MR, Quadir E, Begum A, Begum RA, Begum M. Role of aromatase inhibitor in ovulation induction in patients with poor response to clomiphene citrate. J Obstet Gynaecol Res. 2006;32:502–506
  7. Jee BC, Ku SY, Suh CS, Kim KC, Lee WD, Kim KC, et al. Use of letrozole versus clomiphene citrate combined with gonadotropins in intrauterine insemination cycles: a pilot study. Fertil Steril. 2006;85:1774–1777
  8. Verpoest WM, Kolibianakis E, Papanikolaou E, Smitz J, Van Steirteghem A, Devroev P. Aromatase inhibitors in ovarian stimulation for IVF/ICSI: a pilot study. Reprod Biomed Online. 2006;13:166–172
  9. Barroso G, Menocal G, Felix H, Rojas-Ruiz JC, Arsian M, Oehninger S. Comparison of the efficacy of the aromatase inhibitor letrozole and clomiphene citrate as adjuvants to recombinant follicle-stimulating hormone in controlled ovarian hyperstimulation: a prospective, randomized, blinded clinical trial. Fertil Steril. 2006;86:1428–1431
  10. Goswami SK, Das T, Chattopadhyay R, Sawhney V, Kumar J, Chaudhury K, et al. A randomized single-blind controlled trial of letrozole as a low-cost IVF protocol in women with poor ovarian response: a preliminary report. Hum Reprod. 2004;19:2031–2035
  11. Mitwally MF, Casper RF. Aromatase inhibition reduces gonadotrophin dose required for controlled ovarian stimulation in women with unexplained infertility. Hum Reprod. 2003;18:1588–1597
  12. Bedaiwy MA, Forman R, Mousa NA, Al Inany HG, Casper RF. Cost-effectiveness of aromatase inhibitor cotreatment for controlled ovarian stimulation. Hum Reprod. 2006;21:2838–2844
  13. Al-Fadhli R, Silvestre C, Buckett W, Tan SL, Tulandi T. A randomized trial of superovulation with two different doses of letrozole. Fertil Steril. 2006;85:161–164
  14. World Health Organization . Laboratory manual for the examination of human semen and sperm-cervical mucus interaction. 4th ed.. New York: Cambridge University Press; 1998;
  15. Hughes EG. The effectiveness of ovulation induction and intrauterine insemination in the treatment of persistent infertility: a meta-analysis. Hum Reprod. 1997;12:1865–1872
  16. Vegetti W, Alagna F. FSH and folliculogenesis: from physiology to ovarian stimulation. Reprod Biomed Online. 2006;12:684–694
  17. Sioufi A, Sandrenan N, Godbillon J, Trunet P, Czendlik C, Howald H, et al. Comparative bioavailability of letrozole under fed and fasting conditions in 12 healthy subjects after a 2.5 mg single oral administration. Biopharm Drug Dispos. 1997;18:489–497
  18. Casper RF, Mitwally MF. Review: aromatase inhibitors for ovulation induction. J Clin Endocrinol Metab. 2006;91:760–771
  19. Bedaiwy MA, Mousa NA, Esfandiari N, Forman R, Casper RF. Follicular phase dynamics with combined aromatase inhibitor and follicle stimulating hormone treatment. J Clin Endocrinol Metab. 2007;92:825–833
  20. Wu HH, Wang NM, Cheng ML, Hsieh JN. Randomized comparison of ovulation induction and hormone profile between the aromatase inhibitor anastrozole and clomiphene citrate in women with infertility. Gynecol Endocrinol. 2007;23:76–81
  21. Sipe CS, Davis WA, Maifeld M, Van Voorhis BJ. A prospective randomized trial comparing anastrozole and clomiphene citrate in an ovulation induction protocol using gonadotropins. Fertil Steril. 2006;86:1676–1681
  22. Jain JK, Kuo J. Pregnancy outcomes with increased clomiphene citrate dose. Gynecol Endocrinol. 2004;19:141–145
  23. Unfer V, Casini ML, Costabile L, Mignosa M, Gerli S, Di Renzo GC. High dose of phytoestrogens can reverse the antiestrogenic effects of clomiphene citrate on the endometrium in patients undergoing intrauterine insemination: a randomized trial. J Soc Gynecol Investig. 2004;11:323–328
  24. Healey S, Tan SL, Tulandi T, Biljan MM. Effects of letrozole on superovulation with gonadotropins in women undergoing intrauterine insemination. Fertil Steril. 2003;80:1325–1329
  25. Fatum M, Gyo Y, Diana P, Laufer N, Simon A. Is estradiol mandatory for an adequate follicular and embryo development? A mouse model using aromatase inhibitor (anastrozole). J Assist Reprod Genet. 2006;23:407–412
  26. Papile LA. The Apgar score in the 21st century. N Engl J Med. 2001;344:519–520

PII: S0015-0282(07)03453-X

doi: 10.1016/j.fertnstert.2007.08.060

Fertility and Sterility
Volume 90, Issue 5 , Pages 1818-1825 , November 2008

Article Tools

* Image Usage & Resolution