Fertility and Sterility
Volume 89, Issue 2 , Pages 278-280 , February 2008

Aromatase inhibitors for infertility in polycystic ovary syndrome. The beginning or the end of a new era?

  • Nikolaos P. Polyzos, M.D.

      Affiliations

    • PACMeR (PanHellenic Association for Continual Medical Research), Sections of Obstetrics and Gynaecology and Public Health, Athens, Greece
    • Corresponding Author InformationReprint requests: Nikolaos P. Polyzos, M.D., Panhellenic Association for Continual Medical Research (PACMeR) Section of Obstetrics & Gynaecology, 28 Metamorfoseos St, 38333, Volos, Greece (FAX: +302421038852).
    • ,
  • Maria Tsappi, M.D.

      Affiliations

    • PACMeR (PanHellenic Association for Continual Medical Research), Sections of Obstetrics and Gynaecology and Public Health, Athens, Greece
    • ,
  • Davide Mauri, M.D.

      Affiliations

    • PACMeR (PanHellenic Association for Continual Medical Research), Sections of Obstetrics and Gynaecology and Public Health, Athens, Greece
    • ,
  • Vedat Atay, M.D.

      Affiliations

    • Obstetrics and Gynaecology Department, GATA Haydarpasa Training Hospital, Istanbul, Turkey
    • ,
  • Ivan Cortinovis, Ph.D.

      Affiliations

    • Istituto di Statistica Medica e Biometria, University of Milan, Milan, Italy
    • ,
  • Giovanni Casazza, Ph.D.

      Affiliations

    • Istituto di Statistica Medica e Biometria, University of Milan, Milan, Italy

Received 1 July 2007 ,Revised 1 October 2007 ,Accepted 10 October 2007.

References 

  1. Hammond MG. Monitoring techniques for improved pregnancy rates during clomiphene ovulation induction. Fertil Steril. 1984;42:499–509
  2. Mauri D, Pavlidis N, Polyzos NP, Ioannidis JP. Survival with aromatase inhibitors and inactivators versus standard hormonal therapy in advanced breast cancer: meta-analysis. J Natl Cancer Inst. 2006;98:1285–1291
  3. Mitwally MF, Casper RF. Use of an aromatase inhibitor for induction of ovulation in patients with an inadequate response to clomiphene citrate. Fertil Steril. 2001;75:305–309
  4. Casper RF. Letrozole: ovulation or superovulation?. Fertil Steril. 2003;80:1335–1337
  5. Casper RF, Mitwally MF. Review: aromatase inhibitors for ovulation induction. J Clin Endocrinol Metab. 2006;91:760–771
  6. Sipe CS, Davis WA, Maifeld M, Van Voorhis BJ. A prospective randomized trial comparing anastrozole and clomiphene citrate in an ovulation induction protocol using gonadotropins. Fertil Steril. 2006;86:1676–1681
  7. Atay V, Cam C, Muhcu M, Cam M, Karateke A. Comparison of letrozole and clomiphene citrate in women with polycystic ovaries undergoing ovarian stimulation. J Int Med Res. 2006;34:73–76
  8. Bayar U, Basaran M, Kiran S, Coskun A, Gezer S. Use of an aromatase inhibitor in patients with polycystic ovary syndrome: a prospective randomized trial. Fertil Steril. 2006;86:1447–1451
  9. Sohrabvand F, Ansari Sh, Bagheri M. Efficacy of combined metformin–letrozole in comparison with metformin–clomiphene citrate in clomiphene-resistant infertile women with polycystic ovarian disease. Hum Reprod. 2006;21:1432–1435
  10. In:  Egger M,  Davey Smith G,  Altman DG editor. Systematic reviews in health care: meta-analysis in context. 2nd ed.. London: BMJ Books; 2001;
  11. Badawy A, Abdel Aal I, Abulatta M. Clomiphene citrate or letrozole for ovulation induction in women with polycystic ovarian syndrome: a prospective randomized trial. Fertil Steril. 2007;“in press”
  12. Sereepapong W, Triratanachat S, Sampatanukul P, Pruksananonda K, Boonkasemsanti K, Reinprayoon D. Effects of clomiphene citrate on the endometrium of regularly cycling women. Fertil Steril. 2000;73:287–291
  13. Gonen Y, Casper RF. Sonographic determination of an adverse effect of clomiphene citrate on endometrial growth. Hum Reprod. 1990;5:670–674
  14. Cochrane Handbook. The Cochrane Handbook for Systematic Reviews of Interventions. Available at http://www.cochrane.org/resources/handbook/handbook.pdf. Last accessed September 25, 2007.
  15. Sterne JA, Egger M, Smith GD. Systematic reviews in health care: investigating and dealing with publication and other biases in meta-analysis. BMJ. 2001;323:101–105

 Presented at the 5th World Congress on Ovulation Induction, Rome, Italy, September 13–15, 2007.

PII: S0015-0282(07)03869-1

doi: 10.1016/j.fertnstert.2007.10.016

Fertility and Sterility
Volume 89, Issue 2 , Pages 278-280 , February 2008

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