Fertility and Sterility
Volume 90, Issue 6 , Pages 2217-2221 , December 2008

Prepubertal serum inhibin B in cryptorchid infants and in monorchid boys with compensatory testicular hypertrophy

  • Rossella Gaudino, M.D.

      Affiliations

    • Mother and Child, Biology–Genetics Department, Division of Pediatrics, University of Verona, Verona, Italy
    • Corresponding Author InformationReprint requests: Rossella Gaudino, M.D., Mother and Child, Biology–Genetics Department, Division of Pediatrics, University of Verona, Piazzale L. Scuro 10, 37134 Verona, Italy (FAX: 39-045-8124790).
    • ,
  • Paolo Cavarzere, M.D.

      Affiliations

    • Mother and Child, Biology–Genetics Department, Division of Pediatrics, University of Verona, Verona, Italy
    • ,
  • Marta Camilot, M.D.

      Affiliations

    • Mother and Child, Biology–Genetics Department, Division of Pediatrics, University of Verona, Verona, Italy
    • ,
  • Francesca Teofoli, M.D.

      Affiliations

    • Mother and Child, Biology–Genetics Department, Division of Pediatrics, University of Verona, Verona, Italy
    • ,
  • Nicola Zampieri, M.D.

      Affiliations

    • Pediatric Surgery Department, University of Verona, Verona, Italy
    • ,
  • Luciano Tatò, M.D.

      Affiliations

    • Mother and Child, Biology–Genetics Department, Division of Pediatrics, University of Verona, Verona, Italy

Received 21 August 2007 ,Revised 10 October 2007 ,Accepted 16 October 2007.

References 

  1. Laron Z, Zilka E. Compensatory hypertrophy of testicles in unilateral cryptorchidism. J Clin Endocrinol Metabol. 1969;29:1409–1413
  2. Koff SA. Does compensatory testicular enlargement predict monorchism?. J Urol. 1991;146:627–629
  3. Huff DS, Hadziselimovic F, McSnyder H, Duckett JW, Keating MA. Postnatal testicular maldevelopment in unilateral cryptorchidism. J Urol. 1989;142:546–548
  4. Laron Z, Dickerman Z, Prager-Lewin R, Keret R, Halabe B. Plasma LH and FSH response to LRH in boys with compensatory testicular hypertrophy. J Clin Endocrinol Metab. 1975;40:977–981
  5. Tatò L, Corgnati A, Boner A, Pinelli L, Zatti M, Gaburro D. Unilateral cryptorchidism with compensatory hypertrophy of descended testicle in prepuberal boys. Horm Res. 1978;9:185–193
  6. Laron Z, Dickerman Z, Ritterman I, Kaufman H. Follow-up of boys with unilateral compensatory testicular hypertrophy. Fertil Steril. 1980;33:297–301
  7. Kumanov P, Nandipati K, Tamova A, Agarwal A. Inhibin B is a better marker of spermatogenesis than other hormones in the evaluation of male infertility. Fertil Steril. 2006;86:332–337
  8. Forest MG, Sizonenko PC, Cathiard AM, Bertrand J. Hypophyso-gonadal function in humans during the first year of life. Evidence for testicular activity in early infancy. J Clin Invest. 1974;53:819
  9. Bergadà I, Rojas G, Ropelato G, Ayuso S, Bergadà C, Campo S. Sexual dimorphism in circulating monomeric and dimeric inhibins in normal boys and girls from birth to puberty. Clin Endocrinol. 1999;51:455–460
  10. Andersson AM, Skakkebaek NE. Serum inhibin B levels during male childhood and puberty. Mol Cell Endocrinol. 2001;180:103–107
  11. Andersson AM, Toppari J, Haavisto AM, Petersen JH, Simell T, Simell O, et al. Longitudinal reproductive hormone profiles in infants: peak of inhibin B levels in infant boys exceeds levels in adult men. J Clin Endocrinol Metab. 1998;83:675–681
  12. Kubini K, Zachmann M, Albers N, Hiort O, Bettendorf M, Wölfle J, et al. Basal inhibin B and the testosterone response to human chorionic gonadotropin correlate in prepubertal boys. J Clin Endocrinol Metab. 2000;85:134–138
  13. Ibanez L, Potau N, Zampolli M, Virdis R, Gussinyé M, Carrascosa A, et al. Use of leuprolide acetate response patterns in the early diagnosis of pubertal disorders: comparison with the gonadotropin-releasing hormone test. J Clin Endocrinol Metab. 1994;78:30–35
  14. Lustra DD, Wise TH, Ford JJ. Sertoli cells in the boar testis: changes during development and compensatory hypertrophy after hemicastration at different ages. Biol Reprod. 2003;68:140–150
  15. Brown JL, Chakraborty PK. Comparison of compensatory pituitary and testicular responses to hemicastration between prepubertal and mature rats. J Androl. 1991;12:119–125
  16. Orth JM. Cell biology of testicular development in foetus and neonate. In:  Desjardins C,  Ewing LL editor. Cell and molecular biology of the testis. 1st ed.. New York: Oxford University Press; 1993;p. 3–42
  17. Huff DS, Snyder HM, Hadziselmovic F, Blyth B, Duckett JW. An absent testis is associated with contralateral testicular hypertrophy. J Urol. 1992;148:627–628
  18. Hurwitz RS, Kaptein JS. How well does contralateral testis hypertrophy predict the absence of non-palpable testis?. J Urol. 2001;165:588–592
  19. Rey RA, Campo SM, Bedecarràs P, Nagle CA, Chermes HE. Is infancy a quiescent period of testicular development? Histological, morphometric and functional study of seminiferous tubules of Cebus monkey from birth to the end of puberty. J Clin Endocrinol Metab. 1993;76:1325–1331
  20. Berensztein E, Saraco N, Belgorosky A, Rivarola MA. Secretion of inhibin B by human prepubertal cells in culture. Eur J Endocrinol. 2000;142:481–485
  21. Sharpe RM, Fraser HM, Brougham MFH, McKinnell C, Dorris KD, Kelnar CJH, et al. Role of the neonatal period of pituitary–testicular activity in germ cell proliferation and differentiation in the primate testis. Hum Reprod. 2003;18:2110–2117
  22. Andersson AM, Juul A, Peterson JH, Müller J, Groome NP, SkakkebaeK NE. Serum inhibin B in healthy pubertal and adolescent boys: relation to age, stage of puberty, and follicle-stimulating hormone, luteinizing hormone, testosterone and estradiol levels. J Clin Endocrinol Metab. 1997;82:3976–3982
  23. Crofton PM, Evans AE, Groome NP, Taylor MR, Holland CV, Kelnar CJ. Inhibin B in boys from birth to adulthood: relationship with age, pubertal stage, FSH and testosterone. Clin Endocrinol (Oxf). 2002;56:215–221
  24. Anderson RA, Shape RM. Regulation of inhibin production in the human male and its clinical applications. Int J Androl. 2000;23:136–144
  25. Anawalt BD, Bebb RA, Matsumoto AM, Groome NP, Illingworth PJ, McNeilly AS, et al. Serum inhibin B levels reflect Sertoli cell function in normal men with testicular dysfunction. J Clin Endocrinol Metab. 1996;81:3341–3345
  26. Andersson AM, Petersen JH, Jorgensen N, Jensen TK, Skakkebeak NE. Serum inhibin B and follicle-stimulating hormone levels as tools in the evaluation of infertile men: significance of adequate reference values from proven fertile men. J Clin Endocrinol Metab. 2004;89:2873–2879
  27. Main KM, Toppari J, Suomi AM, Kaleva M, Chellakooty M, Schmidt IM, et al. Larger testes and higher inhibin B levels in Finnish than in Danish newborn boys. J Clin Endocrinol Metab. 2006;91:2732–2737
  28. Skakkebeak NE, Rajpert-De Meyts E, Main KM. Testicular dysgenesis syndrome: an increasingly common developmental disorder with environmental aspects. Hum Reprod. 2001;16:972–978

PII: S0015-0282(07)03870-8

doi: 10.1016/j.fertnstert.2007.10.017

Fertility and Sterility
Volume 90, Issue 6 , Pages 2217-2221 , December 2008

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