Fertility and Sterility
Volume 90, Issue 6 , Pages 2190-2195 , December 2008

Estradiol supplementation during the luteal phase of IVF-ICSI patients: a randomized, controlled trial

  • José Serna, M.D.

      Affiliations

    • IVI-Madrid, Madrid, Spain
    • ,
  • José L. Cholquevilque, M.D.

      Affiliations

    • IVI-Madrid, Madrid, Spain
    • ,
  • Vito Cela, M.D.

      Affiliations

    • Department of Reproductive Medicine, Division of Obstetrics and Gynecology, “P. Fioretti” University of Pisa, Pisa, Italy
    • ,
  • Javier Martínez-Salazar, M.D.

      Affiliations

    • IVI-Madrid, Madrid, Spain
    • ,
  • Antonio Requena, M.D.

      Affiliations

    • IVI-Madrid, Madrid, Spain
    • ,
  • Juan A. Garcia-Velasco, M.D.

      Affiliations

    • IVI-Madrid, Madrid, Spain
    • Rey Juan Carlos University, Madrid, Spain
    • Corresponding Author InformationReprint requests: Juan A Garcia-Velasco, M.D., IVI-Madrid, Santiago de Compostela 88, Madrid, Spain (FAX: 34 91 386 7133).

Received 12 June 2007 ,Revised 3 October 2007 ,Accepted 3 October 2007.

References 

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  2. Engmann L, Diluigi A, Schmidt D, Benadiva C, Maier D, Nulsen J. A prospective randomized trial evaluating the effect of luteal phase estradiol supplementation on the success of IVF treatment. Fertil Steril. 2005;84:S88
  3. Fatemi H, Kolibianakis E, Camus M, Tournaye H, Donoso P, Papanikolau P, et al. Addition of estradiol to progesterone for luteal supplementation in patients stimulated with GnRH antagonist/rFSH for IVF: a randomized controlled trial. Hum Reprod. 2006;21:2628–2632
  4. Lewin A, Benshushan A, Mezker E, Yanai N, Schenker JG, Goshen R. The role of estrogen support during the luteal phase of in vitro fertilization–embryo transplant cycles: a comparative study between progesterone alone and estrogen and progesterone support. Fertil Steril. 1994;62:121–125
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  9. Gorkemli H, Ak D, Akyurek C, Aktan M, Duman S. Comparison of pregnancy outcomes of progesterone or progesterone + estradiol for luteal phase support in ICSI-ET cycles. Gynecol Obstet Invest. 2004;58:140–144
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  11. Lukaszuk K, Liss J, Lukaszuk M, Maj B. Optimization of estradiol supplementation during the luteal phase improves the pregnancy rate in women undergoing in vitro fertilization–embryo transfer cycles. Fertil Steril. 2005;83:1372–1376
  12. Vlahos N, Lipari C, Bankowski B, Lai T, King J, Shih I, et al. Effect of luteal phase support on endometrial L-selectin ligand expression following recombinant follicle stimulating hormone and ganirelix acetate for in vitro fertilization. J Clin Endocrinol Metab. 2006;91:4043–4049
  13. Farhi J, Weissman A, Steinfeld Z, Shorer M, Nahum H, Levran D. Estradiol supplementation during the luteal phase may improve the pregnancy rates in patients undergoing in vitro fertilization-embryo transfer cycles. Fertil Steril. 2000;73:761–766
  14. Adams S, Terry V, Hosie M, Gayer N, Murphy C. Endometrial response to IVF hormonal manipulation: comparative analysis of menopausal, down regulated and natural cycles. Reprod Biol Endocrinol. 2004;2:21
  15. De Ziegler D, Bergeron C, Cornel C, Medalie D, Massai M, Milgrom E, et al. Effects of luteal estradiol on the secretory transformation of human endometrium and plasma gonadotropins. J Clin Endocrinol Metab. 1992;74:322–331
  16. Beckers N, Macklon N, Eijkemans M, Ludwig M, Ferberlbaum R, Diedrich K, et al. Nonsupplemented luteal phase characteristics after the administration of recombinant human chorionic gonadotropin, recombinant luteinizing hormone, or gonadotropin-releasing hormone (GnRH) agonist to induce final oocyte maturation in in vitro fertilization patients after ovarian stimulation with recombinant follicle-stimulating hormone and GnRH antagonist cotreatment. J Clin Endocrinol Metab. 2003;88:4186–4192
  17. Beckers N, Platteau P, Eijkemans M, Macklon N, De Jong F, Devroey P, et al. The early luteal phase administration of estrogen and progesterone does not induce premature luteolysis in normo-ovulatory women. Eur J Endocrinol. 2006;155:355–363
  18. Henzl M, Loomba P. Transdermal delivery of sex steroids for hormone replacement therapy and contraception. A review of principles and practice. J Reprod Med. 2003;48:525–540
  19. Fanchin R, Righini C, Schönauer L, Olivennes F, Cunha Filho J, Frydman R. Vaginal versus oral E2 administration: effects on endometrial thickness, uterine perfusion, and contractility. Fertil Steril. 2001;76:994–998
  20. Yen S, Martin P, Burnier A, Czekala N, Greaney M, Callantine M. Circulating estradiol, estrone and gonadotropin levels following the administration of orally active 17-beta estradiol in postmenopausal women. J Clin Endocrinol. 1975;40:518–521
  21. Hung E, Shu W, Yee E, Wai W, Chung P. A rapid decline in serum oestradiol concentrations around the mid-luteal phase had no adverse effect on outcome in 763 assisted reproduction cycles. Hum Reprod. 2000;15:1903–1908
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  24. Friedler S, Zimerman A, Schachter M, Raziel A, Strassburguer D, Ron El R. The midluteal decline in serum estradiol levels is drastic but not deleterious for implantation after in vitro fertilization and embryo transfer in patients with normal or high responses. Fertil Steril. 2005;83:54–60

PII: S0015-0282(07)03874-5

doi: 10.1016/j.fertnstert.2007.10.021

Fertility and Sterility
Volume 90, Issue 6 , Pages 2190-2195 , December 2008

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