Fertility and Sterility
Volume 90, Issue 6 , Pages 2281-2286 , December 2008

Clomiphene citrate and intrauterine insemination: analysis of more than 4100 cycles

  • Serena Dovey, M.D.

      Affiliations

    • Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center, Boston, Massachusetts
    • Harvard Medical School, Boston, Massachusetts
    • ,
  • Rita M. Sneeringer, M.D.

      Affiliations

    • Boston IVF, Waltham, Massachusetts
    • Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center, Boston, Massachusetts
    • Harvard Medical School, Boston, Massachusetts
    • ,
  • Alan S. Penzias, M.D.

      Affiliations

    • Boston IVF, Waltham, Massachusetts
    • Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center, Boston, Massachusetts
    • Harvard Medical School, Boston, Massachusetts
    • Corresponding Author InformationReprint requests: Alan S. Penzias, M.D., Boston IVF, 130 Second Avenue, Waltham, Massachusetts 02451 (FAX: 781-434-6501).

Received 30 August 2007 ,Revised 31 October 2007 ,Accepted 31 October 2007.

References 

  1. Practice Committee of the American Society for Reproductive Medicine. Use of clomiphene citrate in women. Fertil Steril. 2004;82:S90–S96
  2. Clark JH, Mardaverich BM. The agonist–antagonist properties of clomiphene: a review. Pharmacol Ther. 1982;15:467–519
  3. Palomba S, Orio F, Zullo F. Ovulation induction in women with polycystic ovary syndrome. Fertil Steril. 2006;86:S26–S27
  4. Kousta E, White DM, Frank S. Modern use of clomiphene citrate in induction of ovulation. Hum Reprod Update. 1997;3:359–365
  5. Beck JI, Boothroyd C, Proctor M, Farquhar C, Hughes E. Oral anti-oestrogens and medical adjuncts for subfertility associated with anovulation. Cochrane Database Syst Rev. 2005;1:Art. No.: CD002249. DOI: 10.1002/14651858.CD002249.pub3
  6. Hammond MG, Halme JK, Talbert LM. Factors affecting the pregnancy rate in clomiphene citrate induction of ovulation. Obstet Gynecol. 1983;62:196–202
  7. Homburg R. Clomiphene citrate—end of an era? A mini-review. Hum Reprod. 2005;20:2043–2051
  8. Guzick DS, Sullivan MW, Adamson GD, Cedars MI, Falk RJ, Peterson EP, et al. Efficacy of treatment for unexplained infertility. Fertil Steril. 1998;70:207–213
  9. Dickey RP, Taylor SN, Lu PY, Sartor BM, Rye PH, Pyrzak R. Effect of diagnosis, age, sperm quality, and number of preovulatory follicles on the outcome of multiple cycles of clomiphene citrate—intrauterine insemination. Fertil Steril. 2002;78:1088–1095
  10. Bayar U, Tanriverdi HA, Barut A, Ayoglu F, Ozcan O, Kaya E. Letrozole vs. clomiphene citrate in patients with ovulatory infertility. Fertil Steril. 2006;85:1045–1048
  11. Al-Fozan H, Al-Khadouri M, Tan SL, Tulandi T. A randomized trial of letrozole versus clomiphene citrate in women undergoing superovulation. Fertil Steril. 2004;82:1561–1563
  12. Badawy A, El Nashar BA, El Totongy M. Clomiphene citrate plus N-acetyl cysteine versus clomiphene citrate for augmenting ovulation in the management of unexplained infertility: a randomized double-blind controlled trial. Fertil Steril. 2006;86:647–650
  13. Vlahos NF, Coker L, Lawler C, Zhao Y, Bankowski B, Wallach EE. Women with ovulatory dysfunction undergoing ovarian stimulation with clomiphene citrate for intrauterine insemination may benefit from administration of human chorionic gonadotropin. Fertil Steril. 2005;83:1510–1516
  14. Yilmaz B, Kelekci S, Savan K, Oral H, Mollamahmutoglu L. Addition of human chorionic gonadotropin to clomiphene citrate ovulation induction therapy does not improve pregnancy outcomes and luteal function. Fertil Steril. 2006;85:783–786
  15. Manganiello PD, Stern JE, Stukel TA, Crow H, Brinck-Johnsen T, Weiss JE. A comparison of clomiphene citrate and human menopausal gonadotropin for use in conjunction with intrauterine insemination. Fertil Steril. 1997;68:405–412
  16. Zreik TG, Garcia-Velasco JA, Habboosh MS, Olive DL, Arici A. Prospective, randomized, crossover study to evaluate the benefit of human chorionic gonadotropin-timed versus urinary luteinizing hormone-timed intrauterine inseminations in clomiphene citrate-stimulated treatment cycles. Fertil Steril. 1999;71:1070–1074
  17. Malcolm CE, Cumming DC. Follow up of infertile couples who dropped out of a specialist fertility clinic. Fertil Steril. 2004;81:269–270
  18. Domar AD. Impact of psychological factors on dropout rates in insured infertility patients. Fertil Steril. 2004;81:271–273
  19. Penzias AS. When and why does the dream die? Or does it?. Fertil Steril. 2004;81:274–275
  20. Menken J, Trussell J, Larsen U. Age and fertility. Science. 1986;233:1389–1394
  21. Anderson AM, Wohlfahrt J, Christens P, Olsen J, Melbye M. Maternal age and fetal loss: population based register linkage study. BMJ. 2000;320:1708–1712
  22. Polson DW, Kiddy DS, Mason HD, Frank S. Induction of ovulation with clomiphene citrate in women with polycystic ovary syndrome: the difference between responders and non-responders. Fertil Steril. 1989;51:30–34
  23. Imani B, Eijkemans MJ, te Velde ER, Habbema JD, Fauser BC. A nomogram to predict the probability of live birth after clomiphene citrate induction of ovulation in normogonadotropic oligoamenorrheic infertility. Fertil Steril. 2002;77:91–97
  24. Goto S, Takakura K, Nakanishi K, Yokoi T, Noda Y. Efficacy of clomiphene citrate and cyclofenil for infertile women with normal ovulatory cycles. Fertil Steril. 2001;76:409–411

 Presented at the Society for Gynecologic Investigation, 54th Annual Scientific Meeting Reno, Nevada, March 14–17, 2007.

 Conflicts of interest: Serena Dovey, no conflicts to report; Rita Sneeringer, no conflicts to report; Alan Penzias, Ferring Pharmaceuticals—Research Grant Support; Speakers Bureau; EMD Serono and Organon, Inc.—Research Grant Support.

PII: S0015-0282(07)03942-8

doi: 10.1016/j.fertnstert.2007.10.057

Fertility and Sterility
Volume 90, Issue 6 , Pages 2281-2286 , December 2008

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