Fertility and Sterility
Volume 90, Issue 6 , Pages 2091-2098 , December 2008

Genetic evaluation of oocyte donors: recipient couple preferences and outcome of testing

  • Valerie L. Baker, M.D.

      Affiliations

    • Fertility Physicians of Northern California, San Jose, California
    • Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Stanford University Medical Center, Stanford, California
    • Corresponding Author InformationReprint requests: Valerie L. Baker, M.D., Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Stanford University Medical Center, 300 Pasteur Drive, Room HH333, Stanford, California 94305 (FAX: 650-736-7036).
    • ,
  • Heather M. Rone, B.S.

      Affiliations

    • Fertility Physicians of Northern California, San Jose, California
    • ,
  • Geoffrey David Adamson, M.D.

      Affiliations

    • Fertility Physicians of Northern California, San Jose, California

Received 6 April 2007 ,Revised 30 October 2007 ,Accepted 30 October 2007.

References 

  1. American Society for Reproductive Medicine . Minimal genetic screening for gamete donors. Fertil Steril. 2002;77:S15–S16
  2. Practice Committee of the American Society for Reproductive Medicine; Practice Committee of the Society for Assisted Reproductive Technology. 2006 guidelines for gamete and embryo donation. Fertil Steril. 2006;86:S38–S50
  3. European Society of Human Genetics and European Society of Human Reproduction and Embryology. The need for interaction between assisted reproduction technology and genetics: recommendations of the European Societies of Human Genetics and Human Reproduction and Embryology. Hum Reprod. 2006;21:1071–1073
  4. Schover LR, Thomas AJ, Falcone T, Attaran M, Goldberg J. Attitudes about genetic risk of couples undergoing in-vitro fertilization. Hum Reprod. 1998;13:862–866
  5. Hershberger P, Klock SC, Barnes RB. Disclosure decisions among pregnant women who received donor oocytes: a phenomenological study. Fertil Steril. 2007;87:288–296
  6. Zenke U, Chetkowski RJ. Inclusion of heterozygotes for cystic fibrosis in the egg donor pool. Fertil Steril. 2002;78:557–561
  7. Lewis V, Saller DN, Kouides RW, Garza J. Survey of genetic screening for oocyte donors. Fertil Steril. 1999;71:278–281
  8. American College of Obstetricians and Gynecologists Committee on Genetics. ACOG committee opinion. No. 338: Screening for fragile X syndrome. Obstet Gynecol. 2006;107:1483–1485
  9. Pastore LM, Karns LB, Pinkerton JV, Silverman LM, Williams CD, Camp TR. Acceptance of fragile X premutation genetic screening in women with ovarian dysfunction. Am J Obstet Gynecol. 2006;194:738–743
  10. Spence WC, Black SH, Fallon L, Maddalena A, Cummings E, Menapace-Drew G, et al. Molecular fragile X screening in normal populations. Am J Med Genet. 1996;64:181–183
  11. Ravel C, Letur H, Lannou DL, Barthélémy C, Bresson JL, Siffroi JP, et al. High incidence of chromosomal abnormalities in oocyte donors. Fertil Steril. 2007;87:439–441
  12. Cryos International. Available at: http://www.cryosinternational.com/donor-semen/screening.aspx. Accessed on March 9, 2007.
  13. Carey KN, McCartney J. Wrongful life and wrongful birth: legal aspects of failed testing in oocyte donation. Penn Bioeth J. 2005;1:1–4
  14. Roth R. Congenital disabilities and the law. Clin Perinatol. 2007;34:263–273

 V.L.B. has received research support from Institute Biochimique (IBSA), Switzerland. H.M.R. is an employee of Fertility Physicians of Northern California. G.D.A. is CEO and a shareholder of Advanced Reproductive Care, Palo Alto, CA, and his spouse is a shareholder of Advanced Reproductive Care. G.D.A. is a physician and an owner of Fertility Physicians of Northern California, has received research support from IBSA, has been a speaker for Ferring Pharmaceuticals, Suffern, NY, and is on the LabCorp Advisory Board, Morrisville, NC.

PII: S0015-0282(07)03955-6

doi: 10.1016/j.fertnstert.2007.10.069

Fertility and Sterility
Volume 90, Issue 6 , Pages 2091-2098 , December 2008

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