Fertility and Sterility
Volume 90, Issue 6 , Pages 2080-2085 , December 2008

Lipid peroxidation and vitamin E in serum and follicular fluid of infertile women with peritoneal endometriosis submitted to controlled ovarian hyperstimulation: a pilot study

  • Carla Campos Petean, M.D.

      Affiliations

    • Department of Obstetrics and Gynecology, Ribeirão Preto Medical School, São Paulo University, Ribeirão Preto, São Paulo, Brazil
    • ,
  • Rui Alberto Ferriani, M.D., Ph.D.

      Affiliations

    • Department of Obstetrics and Gynecology, Ribeirão Preto Medical School, São Paulo University, Ribeirão Preto, São Paulo, Brazil
    • ,
  • Rosana Maria dos Reis, M.D., Ph.D.

      Affiliations

    • Department of Obstetrics and Gynecology, Ribeirão Preto Medical School, São Paulo University, Ribeirão Preto, São Paulo, Brazil
    • ,
  • Marcos Dias de Moura, M.D., Ph.D.

      Affiliations

    • Department of Obstetrics and Gynecology, Ribeirão Preto Medical School, São Paulo University, Ribeirão Preto, São Paulo, Brazil
    • ,
  • Alceu Afonso Jordão Jr., Ph.D.

      Affiliations

    • Nutrition Division, Ribeirão Preto Medical School, São Paulo University, Ribeirão Preto, São Paulo, Brazil
    • ,
  • Paula Andrea de Albuquerque Salles Navarro, M.D., Ph.D.

      Affiliations

    • Department of Obstetrics and Gynecology, Ribeirão Preto Medical School, São Paulo University, Ribeirão Preto, São Paulo, Brazil
    • Corresponding Author InformationReprint requests: Paula Andrea de Albuquerque Salles Navarro, M.D., Ph.D., Department of Obstetrics and Gynecology, Ribeirão Preto Medical School, São Paulo University, Avenida Bandeirantes, 3900, Ribeirão Preto, São Paulo 14049-900, Brazil (FAX: 55-16-3633-0946).

Received 30 May 2007 ,Revised 27 October 2007 ,Accepted 27 October 2007.

References 

  1. Diplock AT. Antioxidants and free radicals scavengers. In:  Rice-Evans CA,  Burdon RH editor. Free radical damage and its control. Amsterdam: Elsevier; 1994;p. 113
  2. Wang X, Sharma RK, Sikka SC, Thomas AJ, Falcone T, Agarwal A. Oxidative stress is associated with increased apoptosis leading to spermatozoa DNA damage in patients with male factor infertility. Fertil Steril. 2003;80:531–535
  3. Baker MA, Aitken RJ. Reactive oxygen species in spermatozoa: methods for monitoring and significance for the origins of genetic disease and infertility. Reprod Biol Endocrinol. 2005;29:3–67
  4. Nallella KP, Sharma RK, Allamaneni SS, Agarwal A. Identification of male factor infertility using a novel semen quality score and reactive oxygen species levels. Clinics. 2005;60:317–324
  5. Oyawoye O, Abdel Gadir A, Garner A, Constantinovici N, Perrett C, Hardiman P. Antioxidants and reactive oxygen species in follicular fluid of women undergoing IVF: relationship to outcome. Hum Reprod. 2003;18:2270–2274
  6. Pasqualotto EB, Agarwal A, Sharma RK, Izzo VM, Pinotti JA, Joshi NJ, et al. Effect of oxidative stress in follicular fluid on the outcome of assisted reproductive procedures. Fertil Steril. 2004;81:973–976
  7. Agarwal A, Gupta S, Sharma R. Oxidative stress and its implications in female infertility—a clinician's perspective. Reprod Biomed Online. 2005;11:641–650
  8. Murphy AA, Santanam N, Parthasarathy S. Endometriosis: a disease of oxidative stress?. Sem Reprod Endocrinol. 1998;16:263–273
  9. Van Langendonckt A, Casanas-Roux F, Donnez J. Oxidative stress and peritoneal endometriosis. Fertil Steril. 2002;77:861–870
  10. Van Blerkom J, Antczak M, Schrader R. The developmental potential of the human oocyte is related to the dissolved oxygen content of follicular fluid: association with vascular endothelial growth factor levels and perifollicular blood flow characteristics. Hum Reprod. 1997;12:1047–1055
  11. Barnhart K, Dunsmoor-Su R, Coutifaris C. Effect of endometriosis on in vitro fertilization. Fertil Steril. 2002;77:1148–1155
  12. Kuivasaari P, Hippelainen M, Anttila M, Heinonen S. Effect of endometriosis on IVF/ICSI outcome: stage III/IV endometriosis worsens cumulative pregnancy and live-born rates. Hum Reprod. 2005;20:3130–3135
  13. Halliwell B, Gutteridge JMC. Free radicals in biology and medicine. 2nd ed.. New York: Oxford University Press; 1989;
  14. Murphy AA, Santanam N, Morales AJ, Parthasarathy S. Lysophosphatidyl choline, a chemotactic factor for monocytes/T-lymphocytes is elevated in endometriosis. J Clin Endocrinol Metab. 1998;83:2110–2113
  15. Levay PF, Huyser C, Fourie FL, Rossouw DJ. The detection of blood contamination in human follicular fluid. J Assist Reprod Genet. 1997;14:212–217
  16. Arnaud J, Fortis I, Blachier S, Kia D, Favier A. Simultaneous determination of retinol, a-tocopherol and b-carotene in serum by isocratic high performance liquid chromatography. J Chromatogr. 1991;572:103–106
  17. Murphy AA, Palinski W, Rankin S, Morales AJ, Parthasarathy S. Evidence for oxidatively modified lipid-protein complexes in endometrium and endometriosis. Fertil Steril. 1998;69:1092–1094
  18. Szczepanska M, Kozlik J, Skrzypczak J, Mikolajczyk M. Oxidative stress may be a piece in the endometriosis puzzle. Fertil Steril. 2003;79:1288–1293
  19. Paszkowski T, McMaster D, Traub AI. Total iron levels in the preovulatory follicular fluid of in vitro fertilization patients. Med Sci Res. 1996;24:187–188
  20. Kaya H, Sezik M, Ozkaya O, Dittrich R, Siebzehnrubl E, Wildt L. Lipid peroxidation at various estradiol concentrations in human circulation during ovarian stimulation with exogenous gonadotropins. Horm Metab Res. 2004;36:693–695
  21. Jozwik M, Wolcznski S, Jozwik M, Szamatowicz M. Oxidative stress markers in preovulatory follicular fluid in humans. Mol Hum Reprod. 1999;5:409–413
  22. Garrido N, Navarro J, Garcia-Velasco J, Remoh J, Pellice A, Simon C. The endometrium versus embryonic quality in endometriosis-related infertility. Hum Reprod Update. 2002;8:95–103
  23. Attaran M, Pasqualotto E, Falcone T, Goldeberg JM, Miller KF, Agarwal A, et al. The effect of follicular fluid reactive oxygen species on the outcome of in vitro fertilization. Int J Fertil Womens Med. 2000;45:314–320
  24. Das S, Chattopadhyay R, Ghosh S, Ghosh S, Goswami SK, Chakravarty BN, et al. Reactive oxygen species level in follicular fluid—embryo quality marker in IVF?. Hum Reprod. 2006;21:2403–2407

 Supported by a scholarship granted by Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)–Brazil (C.C.P.).

PII: S0015-0282(07)03958-1

doi: 10.1016/j.fertnstert.2007.10.072

Fertility and Sterility
Volume 90, Issue 6 , Pages 2080-2085 , December 2008

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