Fertility and Sterility
Volume 91, Issue 1 , Pages 62-66 , January 2009

Investigating the association between inhibin alpha gene promoter polymorphisms and premature ovarian failure

  • Kathryn J. Woad, Ph.D.

      Affiliations

    • Discipline of Oncology, University of Auckland, Auckland, New Zealand
    • Corresponding Author InformationReprint requests: Kathryn J. Woad, Ph.D., Discipline of Oncology, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand (FAX: 64-9-373-7927).
    • ,
  • Shona M. Pearson, B.Sc. (Hons.)

      Affiliations

    • Department of Obstetrics and Gynaecology, University of Auckland, Auckland, New Zealand
    • ,
  • Sarah E. Harris, Ph.D.

      Affiliations

    • Department of Psychology, University of Edinburgh, Edinburgh, United Kingdom
    • ,
  • Ksenija Gersak, Ph.D.

      Affiliations

    • Department of Obstetrics and Gynaecology, University Medical Centre, Ljubljana, Slovenia
    • ,
  • Andrew N. Shelling, Ph.D.

      Affiliations

    • Department of Obstetrics and Gynaecology, University of Auckland, Auckland, New Zealand

Received 26 June 2007 ,Revised 5 November 2007 ,Accepted 5 November 2007.

References 

  1. Coulam CB, Adamson SC, Annegers JF. Incidence of premature ovarian failure. Obstet Gynecol. 1986;67:604–606
  2. Shelling AN, Burton KA, Chand AL, van Ee CC, France JT, Farquhar CM, et al. Inhibin: a candidate gene for premature ovarian failure. Hum Reprod. 2000;15:2644–2649
  3. Woad KJ, Watkins WJ, Prendergast D, Shelling AN. The genetic basis of premature ovarian failure. Aust NZ J Obstet Gynaecol. 2006;46:242–244
  4. Marozzi A, Porta C, Vegetti W, Crosignani PG, Tibiletti MG, Dalpra L, et al. Mutation analysis of the inhibin alpha gene in a cohort of Italian women affected by ovarian failure. Hum Reprod. 2002;17:1741–1745
  5. Dixit H, Rao KL, Padmalatha V, Kanakavalli M, Deenadayal M, Gupta N, et al. Expansion of the germline analysis for the INHA gene in Indian women with ovarian failure. Hum Reprod. 2006;21:1643–1644
  6. Montgomery GW, Duffy DL, Hall J, Haddon BR, Kudo M, McGee EA, et al. Dizygotic twinning is not linked to variation at the alpha-inhibin locus on human chromosome 2. J Clin Endocrinol Metab. 2000;85:3391–3395
  7. Harris SE, Chand AL, Winship IM, Gersak K, Nishi Y, Yanase T, et al. INHA promoter polymorphisms are associated with premature ovarian failure. Mol Hum Reprod. 2005;11:779–784
  8. Devaney JM, Girard JE, Marino MA. DNA microsatellite analysis using ion-pair reversed-phase high-performance liquid chromatography. Anal Chem. 2000;72:858–864
  9. Sundblad V, Chiauzzi VA, Andreone L, Campo S, Charreau EH, Dain L. Controversial role of inhibin alpha-subunit gene in the aetiology of premature ovarian failure. Hum Reprod. 2006;21:1154–1160
  10. Tremblay JJ, Viger RS. GATA factors differentially activate multiple gonadal promoters through conserved GATA regulatory elements. Endocrinology. 2001;142:977–986
  11. Weck J, Mayo KE. Switching of NR5A proteins associated with the inhibin alpha-subunit gene promoter after activation of the gene in granulosa cells. Mol Endocrinol. 2006;20:1090–1103
  12. Burkart AD, Mukherjee A, Sterneck E, Johnson PF, Mayo KE. Repression of the inhibin alpha-subunit gene by the transcription factor CCAAT/enhancer-binding protein-beta. Endocrinology. 2005;146:1909–1921
  13. Burkart AD, Mukherjee A, Mayo KE. Mechanism of repression of the inhibin alpha-subunit gene by inducible 3′,5′-cyclic adenosine monophosphate early repressor. Mol Endocrinol. 2006;20:584–597
  14. Rich A, Zhang S. Z-DNA: the long road to biological function. Nat Rev Genet. 2003;4:566–572
  15. Ho PS, Ellison MJ, Quigley GJ, Rich A. A computer aided thermodynamic approach for predicting the formation of Z-DNA in naturally occurring sequences. EMBO J. 1986;5:2737–2744

 Supported by the University of Auckland Research Committee, Health Research Council of New Zealand, and Auckland Medical Research Foundation (all, Auckland, New Zealand).

PII: S0015-0282(07)03977-5

doi: 10.1016/j.fertnstert.2007.11.012

Fertility and Sterility
Volume 91, Issue 1 , Pages 62-66 , January 2009

Article Tools

* Image Usage & Resolution