CAG repeat polymorphism in the androgen receptor: a study on the effect of different numbers of repeats using Gene Ontology technique
Received 7 August 2007; received in revised form 14 November 2007; accepted 14 November 2007. published online 28 January 2008.
Objective
To study the effect of different numbers of repeats of the AR.
Design
Experimental study.
Setting
A university in Thailand.
Patient(s)
Nucleic acid sequences of the general male population.
Intervention(s)
A new Gene Ontology technology to predict the aberration of the molecular function of the AR as a result of different numbers of repeats of CAG.
Main Outcome Measure(s)
Molecular function.
Result(s)
Repeats of CAG up to 127 times cause no effect on expression of AR in molecular function. Indeed, there have been limited reports on the number of repeats and correlation to clinical phenotypes.
Conclusion(s)
The number of repeats is very high, and there has been no prior report indicating as many repeats as we found. Therefore, the CAG repeat polymorphism in AR appears to be a nonsignificant polymorphism in affecting gross phenotype.
Department of Laboratory Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
Reprint requests: Viroj Wiwanitkit, M.D., Department of Laboratory Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand 10330 (FAX: 662-2524636).
ABSTRACT