Pretreatment with gonadotropin-releasing hormone (GnRH) antagonists to prevent the flare-up effect of long-acting GnRH agonists: results of a pilot study

Received 11 April 2007; received in revised form 19 November 2007; accepted 19 November 2007. published online 18 April 2008.

This study evaluated in vivo whether the flare-up effect of GnRH agonists can be suppressed through pretreatment with a GnRH antagonist. The classic flare-up effect caused by 3.8 mg goserelin acetate could not be suppressed through pretreatment using a single dosage of 3.24 mg cetrorelix acetate.

a Department of Obstetrics and Gynecology, Erlangen University Hospital, Erlangen, Germany

b Department of Obstetrics and Gynecology, Mainz University Hospital, Mainz, Germany

c Department of Biometry and Epidemiology, University Erlangen–Nuremburg, Germany

Reprint requests: Andreas Mueller, M.D., Ph.D., Department of Obstetrics and Gynecology, Erlangen University Hospital, Universitätsstrasse 21–23, D-91054 Erlangen, Germany (Fax: +49-9131-8533552).

PII: S0015-0282(07)04132-5

doi:10.1016/j.fertnstert.2007.11.066

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