Fertility and Sterility
Volume 91, Issue 2 , Pages 647-648 , February 2009

Pretreatment with gonadotropin-releasing hormone (GnRH) antagonists to prevent the flare-up effect of long-acting GnRH agonists: results of a pilot study

  • Andreas Mueller, M.D., Ph.D.

      Affiliations

    • Department of Obstetrics and Gynecology, Erlangen University Hospital, Erlangen, Germany
    • Corresponding Author InformationReprint requests: Andreas Mueller, M.D., Ph.D., Department of Obstetrics and Gynecology, Erlangen University Hospital, Universitätsstrasse 21–23, D-91054 Erlangen, Germany (Fax: +49-9131-8533552).
    • ,
  • Theodoros Maltaris, M.D.

      Affiliations

    • Department of Obstetrics and Gynecology, Mainz University Hospital, Mainz, Germany
    • ,
  • Lothar Häberle, Ph.D.

      Affiliations

    • Department of Biometry and Epidemiology, University Erlangen–Nuremburg, Germany
    • ,
  • Inge Hoffmann, M.T.

      Affiliations

    • Department of Obstetrics and Gynecology, Erlangen University Hospital, Erlangen, Germany
    • ,
  • Matthias W. Beckmann, M.D., Ph.D.

      Affiliations

    • Department of Obstetrics and Gynecology, Erlangen University Hospital, Erlangen, Germany
    • ,
  • Ralf Dittrich, Ph.D.

      Affiliations

    • Department of Obstetrics and Gynecology, Erlangen University Hospital, Erlangen, Germany

Received 11 April 2007 ,Revised 19 November 2007 ,Accepted 19 November 2007.

References 

  1. Roth CL, Brendel L, Rueckert C, Hartmann K. Antagonistic and agonistic GnRH analogue treatment of precocious puberty: tracking gonadotropin concentrations in urine. Horm Res. 2005;63:257–262
  2. Mardesic T, Snajderova M, Sramkova L, Keslova P, Sedlacek P, Stary J. Protocol combining GnRH agonists and GnRH antagonists for rapid suppression and prevention of gonadal damage during cytotoxic therapy. Eur J Gynaecol Oncol. 2004;25:90–92
  3. Mueller A, Binder H, Cupisti S, Hoffmann I, Beckmann MW, Dittrich R. Effects on the male endocrine system of long-term treatment with gonadotropin-releasing hormone agonists and estrogens in male-to-female transsexuals. Horm Metab Res. 2006;38:183–187
  4. Dittrich R, Binder H, Cupisti S, Hoffmann I, Beckmann MW, Mueller A. Endocrine treatment of male-to-female transsexuals using gonadotropin-releasing hormone agonist. Exp Clin Endocrinol Diabetes. 2005;113:586–592
  5. Engel JB, Schally AV. Drug insight: clinical use of agonists and antagonists of luteinizing-hormone-releasing hormone. Nat Clin Pract Endocrinol Metab. 2007;3:157–167
  6. Maiti K, Li JH, Wang AF, Acharjee S, Kim WP, Im WB, et al. GnRH-II analogs for selective activation and inhibition of nonmammalian and type-II mammalian GnRH receptors. Mol Cells. 2003;16:173–179
  7. Caunt CJ, Hislop JN, Kelly E, Matharu AL, Green LD, Sedgley KR, et al. Regulation of gonadotropin-releasing hormone receptors by protein kinase C: inside out signalling and evidence for multiple active conformations. Endocrinology. 2004;145:3594–3602

PII: S0015-0282(07)04132-5

doi: 10.1016/j.fertnstert.2007.11.066

Fertility and Sterility
Volume 91, Issue 2 , Pages 647-648 , February 2009

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