The efficacy of the transfer of twice frozen-thawed embryos with the vitrification method
Objective
To confirm the clinical benefits of recryopreserved, twice-thawed embryo transfer (ET).
Design
Retrospective study.
Setting
Private fertility clinic.
Patient(s)
Forty-nine women whose embryos had been refrozen after a previous frozen-thawed ET.
Intervention(s)
None.
Main Outcome Measure(s)
Comparison of implantation and pregnancy rates of twice-cryopreserved, twice-thawed embryos versus once-cryopreserved, once-thawed embryos.
Result(s)
The pregnancy rate per ET cycle was 27.8% in the refrozen group and 25.9% in the control group (no statistically significant difference). The implantation rate was 25.0% in the refrozen group and 19.3% in the control group (no statistically significant difference).
Conclusion(s)
The refreezing of supernumerary embryos can prevent ovarian hyperstimulation syndrome in stimulated patients and in those who have experienced repeated failed pregnancies. If unexpected supernumerary embryos are available for recryopreservation after frozen-thawed ET, these embryos may be revitrified for a future transfer.
Key Words: Supernumerary embryo, refrozen embryos, vitrification, OHSS, PCOS
To access this article, please choose from the options below
Y.K. has nothing to disclose. E.O. has nothing to disclose. T.U. has nothing to disclose. Y.A. has nothing to disclose.
PII: S0015-0282(07)04144-1
doi:10.1016/j.fertnstert.2007.11.079
© 2009 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.

