Fertility and Sterility
Volume 91, Issue 2 , Pages 528-534 , February 2009

Expression of vascular endothelial growth factor-A and its receptor-1 in a luteal endometrium in patients with repeated in vitro fertilization failure

  • Byung Chul Jee, M.D.

      Affiliations

    • Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Seongnam, Korea
    • ,
  • Chang Suk Suh, M.D.

      Affiliations

    • Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Seongnam, Korea
    • Department of Obstetrics and Gynecology, College of Medicine, Seoul National University, Seoul, Korea
    • ,
  • Ki Chul Kim, M.D.

      Affiliations

    • Hamchoon Women's Clinics, Seoul, Korea
    • ,
  • Won Don Lee, M.D.

      Affiliations

    • Maria Infertility Clinics, Seoul, Korea
    • ,
  • Haeryoung Kim, M.D.

      Affiliations

    • Department of Pathology, Seoul National University Bundang Hospital, Seongnam, Korea
    • ,
  • Seok Hyun Kim, M.D.

      Affiliations

    • Department of Obstetrics and Gynecology, College of Medicine, Seoul National University, Seoul, Korea
    • Corresponding Author InformationReprint requests: Seok Hyun Kim, M.D., Department of Obstetrics and Gynecology, College of Medicine, Seoul National University, 28 Yeongeon, Chongno, Seoul 110-744, Korea (FAX: 82-2-762-3599).
    • ,
  • Seoul National University College of Medicine Assisted Reproductive Technology (SMART) Study Group

Received 1 October 2007 ,Revised 20 November 2007 ,Accepted 27 November 2007.

References 

  1. Gordon JD, Shifren JL, Foulk RA, Taylor RN, Jaffe RB. Angiogenesis in the human female reproductive tract. Obstet Gynecol Surv. 1995;50:688–697
  2. Risau W. Mechanisms of angiogenesis. Nature. 1997;386:671–674
  3. Smith SK. Angiogenesis, vascular endothelial growth factor and the endometrium. Hum Reprod Update. 1998;4:509–519
  4. Jaffe RB. Importance of angiogenesis in reproductive physiology. Semin Perinatol. 2000;24:79–81
  5. Smith SK. Regulation of angiogenesis in the endometrium. Trends Endocrinol Metab. 2001;12:147–151
  6. Sunder S, Lenton EA. Endocrinology of the peri-implantation period. Baillieres Best Pract Res Clin Obstet Gynaecol. 2000;14:789–800
  7. Li XF, Gregory J, Ahmed A. Immunolocalisation of vascular endothelial growth factor in human endometrium. Growth Factors. 1994;11:277–282
  8. Neufeld G, Cohen T, Gengrinovitch S, Poltorak Z. Vascular endothelial growth factor (VEGF) and its receptors. FASEB J. 1999;13:9–22
  9. Charnock-Jones DS, Sharkey AM, Rajput-Williams J, Burch D, Schofield JP, Fountain SA, et al. Identification and localization of alternately spliced mRNAs for vascular endothelial growth factor in human uterus and estrogen regulation in endometrial carcinoma cell lines. Biol Reprod. 1993;48:1120–1128
  10. Smith SK. Angiogenesis and implantation. Hum Reprod. 2000;15(Suppl 6):59–66
  11. Carmeliet P, Ferreira V, Breier G, Pollefeyt S, Kieckens L, Gertsenstein M, et al. Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele. Nature. 1996;380:435–439
  12. Shifren JL, Tseng JF, Zaloudek CJ, Ryan IP, Meng YG, Ferrara N, et al. Ovarian steroid regulation of vascular endothelial growth factor in the human endometrium: implications for angiogenesis during the menstrual cycle and in the pathogenesis of endometriosis. J Clin Endocrinol Metab. 1996;81:3112–3118
  13. Torry DS, Holt VJ, Keenan JA, Harris G, Caudle MR, Torry RJ. Vascular endothelial growth factor expression in cycling human endometrium. Fertil Steril. 1996;66:72–80
  14. Sugino N, Kashida S, Karube-Harada A, Takiguchi S, Kato H. Expression of vascular endothelial growth factor (VEGF) and its receptors in human endometrium throughout the menstrual cycle and in early pregnancy. Reproduction. 2002;123:379–387
  15. Ancelin M, Buteau-Lozano H, Meduri G, Osborne-Pellegrin M, Sordello S, Plouet J, et al. A dynamic shift of VEGF isoforms with a transient and selective progesterone-induced expression of VEGF189 regulates angiogenesis and vascular permeability in human uterus. Proc Natl Acad Sci U S A. 2002;99:6023–6028
  16. Krussel JS, Casan EM, Raga F, Hirchenhain J, Wen Y, Huang HY, et al. Expression of mRNA for vascular endothelial growth factor transmembraneous receptors Flt1 and KDR, and the soluble receptor sflt in cycling human endometrium. Mol Hum Reprod. 1999;5:452–458
  17. Perrot-Applanat M, Ancelin M, Buteau-Lozano H, Meduri G, Bausero P. Ovarian steroids in endometrial angiogenesis. Steroids. 2000;65:599–603
  18. Hoozemans DA, Schats R, Lambalk CB, Homburg R, Hompes PG. Human embryo implantation: current knowledge and clinical implications in assisted reproductive technology. Reprod Biomed Online. 2004;9:692–715
  19. Jinno M, Ozaki T, Iwashita M, Nakamura Y, Kudo A, Hirano H. Measurement of endometrial tissue blood flow: a novel way to assess uterine receptivity for implantation. Fertil Steril. 2001;76:1168–1174
  20. Noyes RW, Hertig AT, Rock J. Dating the endometrial biopsy. Fertil Steril. 1950;1:3–25
  21. Lessey BA. The role of the endometrium during embryo implantation. Hum Reprod. 2000;15(Suppl 6):39–50
  22. Mints M, Blomgren B, Falconer C, Fianu-Jonasson A, Palmblad J. Microvascular density, vascular endothelial growth factor A, and its receptors in endometrial blood vessels in patients with menorrhagia. Fertil Steril. 2005;84:692–700
  23. Bourlev V, Volkov N, Pavlovitch S, Lets N, Larsson1 A, Olovsson M. The relationship between microvessel density, proliferative activity and expression of vascular endothelial growth factor-A and its receptors in eutopic endometrium and endometriotic lesions. Reproduction. 2006;132:501–509
  24. Möller B, Rasmussen C, Lindblom B, Olovsson M. Expression of the angiogenic growth factors VEGF, FGF-2, EGF and their receptors in normal human endometrium during the menstrual cycle. Mol Hum Reprod. 2001;5:65–72
  25. Girling JE, Rogers PA. Recent advances in endometrial angiogenesis research. Angiogenesis. 2005;8:89–99
  26. Goodger AM, Rogers PA. Endometrial endothelial cell proliferation during the menstrual cycle. Hum Reprod. 1994;9:399–405
  27. Rogers PA, Lederman F, Taylor N. Endometrial microvascular growth in normal and dysfunctional states. Hum Reprod Update. 1998;4:503–508
  28. Gargett CE, Lederman FL, Lau TM, Taylor NH, Rogers PA. Lack of correlation between vascular endothelial growth factor production and endothelial cell proliferation in the human endometrium. Hum Reprod. 1999;14:2080–2088
  29. Ferrara N, Davis-Smyth T. The biology of vascular endothelial growth factor. Endocr Rev. 1997;18:4–25
  30. Ferrara N. Molecular and biological properties of vascular endothelial growth factor. J Mol Med. 1999;77:527–543
  31. Margalioth EJ, Ben-Chetrit A, Gal M, Eldar-Geva T. Investigation and treatment of repeated implantation failure following IVF-ET. Hum Reprod. 2006;21:3036–3043
  32. Krussel JS, Bielfeld P, Polan ML, Simon C. Regulation of embryonic implantation. Eur J Obstet Gynecol Reprod Biol. 2003;110(Suppl 1):S2–S9
  33. Simon C, Dominguez F. Embryonic-endometrial interactions at implantation in humans. Gynecol Obstet Invest. 2004;57:28–30
  34. Christiansen OB, Nielsen HS, Kolte AM. Future directions of failed implantation and recurrent miscarriage research. Reprod Biomed Online. 2006;13:71–83

PII: S0015-0282(07)04146-5

doi: 10.1016/j.fertnstert.2007.11.081

Fertility and Sterility
Volume 91, Issue 2 , Pages 528-534 , February 2009

Article Tools

* Image Usage & Resolution